Conserved Protein Domain Family
NuA4

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pfam09340: NuA4 
Histone acetyltransferase subunit NuA4
The NuA4 histone acetyltransferase (HAT) multisubunit complex is responsible for acetylation of histone H4 and H2A N-terminal tails in yeast. NuA4 complexes are highly conserved in eukaryotes and play primary roles in transcription, cellular response to DNA damage, and cell cycle control.
Statistics
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PSSM-Id: 462763
Aligned: 125 rows
Threshold Bit Score: 54.8329
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002118693  18 KLKEIQAN-----KEELTRNLQDIEYQIYCRERKLFQTSr-KFGNVAT-GLkvQAIFNdssqhesdkssmcstdcckygr 90 
XP_002808831   1 -MKHKVKRdimkcKKKLESSIKALEEKILRLELEYHKNCnvNGGNLIK-GW--ESHLR---------------------- 54 
XP_679920      1 -MKHKVKKdiikcKKKLENSIKALEEKIFRLETEYHKNCnvDGGNLLK-GW--DSYLR---------------------- 54 
ESS35808      44 VLNEMISL-----QEKLESDIQHIEAKIYEMEGDYLAATa-DVGNMIK-GW--EGYISs--------------------s 94 
XP_627522     45 LSNEMVSL-----REKVQEELVDIERKIYELETFYWNQTt-DIGNMLR-GW--DGYATyns----------------ntg 99 
XP_001419739  10 HLKQR--------RAKIEADAAEIERQVYDLETSLLTDHs-SGGNVLR-GF--ELALAqs------------------kq 59 
Q4DPF3        40 QLQQLQKR-----REALESHLETLDLRVYDLETAYLRQYv-ELGGCLFdGFglERQQQwggvtaa---------aaagsq 104 Trypanosoma cruzi
Q38FN2        42 QLQYLQAR-----REAIERQLEGLDVCVYDLETTYLRHYv-ELGGCLFdGFglERQQLwctatat---------atatst 106 Trypanosoma brucei
EDP05905      13 DLVELQKK-----RKELADQLRKCETQIHQLETQYLEMAn-PQGNALR-GY--EGLLSsms-----------------aa 66 
ANM66595      14 MLTSLLNK-----REKLRQELRSIEKQVYELETSYLQESs-HIGNALK-GF--EGFLSss------------------ks 66 
XP_002118693  91 QRAER-------ShsSLDagddcmnlsrnspgqegAMKDE----FIFSLSSMTSP 134
XP_002808831  55 KTPLEplsfrtfR----------------------DDYGDsyveRMLSLTSCTSP 87 
XP_679920     55 KTQIEplcfktfR----------------------DDYSDayieRILSLTSCTSP 87 
ESS35808      95 AKARRppgklstP----------------------SGAQD----RLFSLTSCTSR 123
XP_627522    100 SIGGRkssiggnRgsCRSnp-------------nvFSEKD----RWFSLSSVTSP 137
XP_001419739  60 QAQKR----------VKP-----------------FKTEE----RTFSVSSASSQ 83 
Q4DPF3       105 AAAYRarl-------------------------hsFSPSD----RVFTASSVGAL 130 Trypanosoma cruzi
Q38FN2       107 SASTT-------AssSSLgtaldarvaayrerlhrFTPSD----RIFTASSVGAL 150 Trypanosoma brucei
EDP05905      67 AAAEK-------K--GAT-----------------FRGED----RIFSGSSTTGR 91 
ANM66595      67 TASAK-------R--SRK-----------------FQPED----RVFSLSSVTSP 91 
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