Conserved Protein Domain Family
CENP-Q
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pfam13094: CENP-Q 
CENP-Q, a CENPA-CAD centromere complex subunit
CENP-Q is one of the components that assembles onto the CENPA-nucleosome distal (CAD) centromere. The centromere, which is the basic element of chromosome inheritance, is epigenetically determined in mammals. CENP-A, the centromere-specific histone H3 variant, assembles an array of nucleosomes and it is this that seems to be the prime candidate for specifying centromere identity. CENPA nucleosomes directly recruit a proximal CENPA-nucleosome-associated complex (NAC) comprised of CENP-M, CENP-N and CENP-T, CENP-U(50), CENP-C and CENP-H. Assembly of the CENPA NAC at centromeres is dependent on CENP-M, CENP-N and CENP-T. Additionally, there are seven other subunits which make up the CENPA-nucleosome distal (CAD) centromere, CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S, also assembling on the CENP-A NAC. Fta7 is the equivalent component of the fission yeast Sim4 complex.
Links
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Statistics
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PSSM-Id: 432970
Aligned: 78 rows
Threshold Bit Score: 56.912
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ERS99257      62 VRSKLVKgIPFPPgtvhivsrrgrpstkplpdddrNGLAADFNFERAVEEAHALEQQLSPLQHAVALLKRERKHEEEALA 141
ABN64840      86 FRSRLEV-TKVPApssma-------------tnksNEISDILSYDQLSRRKTFLETYLNAELKQLSDLQKHYQGMEVAYQ 151
XP_007374939 154 FKSRLRV-TKVPLpstmf-------------pnnkGTIKDVFNYDKVLERKQFLETCLSAELKQLQDLEKYYHETKMIYE 219
CCE78463     317 FISRLKH-TNVPPastmqt-----------sskfnPRDLDVLDHDALARRLKYLETYLSAELKQLSDLEKYYSDLEFIYK 384
Q6BJB1       337 FRSRLNV-TNVPLpstmqs-----------tsksiDNSLDILDYDQLTRRTQFLETYLLAELKQLSDLETYYSDLEMIYN 404 Debaryomyces ha...
Q5A0H0        92 FKSRLSQ-TKLPPpssmyss---------klriraNEVADVLSYDSLTRKRTVLETYLSAELKQLQELENHYNQSLLAYK 161 Candida albicans
XP_002547026 112 FKARLDQ-TNLPPpnsmynt---------kvrikaNEIKDVLSYDSVSRKKTALETYLSAELKQLQELEDHYNQMLLSHQ 181
EMG50891      96 FRSRLQL-TKLPPpnsmyvh---------hvrnktNDLKNAFDYDSVLRKKTVLETYLSAELSSLHELEQTYNQSVLMYD 165
XP_006683672 157 FKRRLQT-TKLPRrvsihs-----------tnpqnDENKYVLNHDILNRRKTFLETYLSAELKQLKDLTKTYNKIELNYK 224
XP_001485277 141 FLSRLKV-TKVPLptshs-------------krnsSEDMNVLAFDSLNRRKKFLETYLQAELKQVNQLEKYHKELSTVYQ 206

ERS99257     142 ADYAALRQLETNAQADLRT-WRD--RTRRAHVLAPVDVGDNRSLKGGNDDSLqfvelakrapalggndhgkdenenneng 218
ABN64840     152 SDLEYLEEFRKTTASHAKDvNKDitNIRESLGLDARNGSSDNIKLTSKTDT----------------------------- 202
XP_007374939 220 SDKKYLSELTRATNGKEAKlRHQmyTQREELGLDEEIKPDVDLNLATSGTS----------------------------- 270
CCE78463     385 SDDAYSKDFDKTVSANVSSmHEKlyQKKSELSISDIADPENHNIVLVEKHNS---------------------------- 436
Q6BJB1       405 LDLNYLNEFKKTTEINKSKmIKEtiMKREKLSLDNIEPDRENIRLADHSVLT---------------------------- 456 Debaryomyces ha...
Q5A0H0       162 SDLEYLKKFKSTVKNNESKyNEEleRKREELNLSVQNKNPDDIYLLSTDN------------------------------ 211 Candida albicans
XP_002547026 182 SDLQYLQKFKQTSKRHQLKlDSDidDIHEELNLIEYDKKPDDIYLQSNST------------------------------ 231
EMG50891     166 RDVGYFGTFKGTVKGEERRlDEEiqAMEEELALFEYSKLPDNIYLKKKKMD----------------------------- 216
XP_006683672 225 SDLEYLKEFNKTVEANESKmSQEvyTKKTTMNLKYSDTSNLDSDVTSSNV------------------------------ 274
XP_001485277 207 QDLQYLQEFKKTTEIEIKSmTEEatELRRNMGLENSKNTPEGEYVEKPVK------------------------------ 256

ERS99257     219 qsrdksqnggLFEHL----DKDLSTVAAQLSNHMDSLKSNLQQIAGVLPAMTQTKAAL 272
ABN64840     203 -----------KSSFnpdeDDATKELLQSLHSHLQSISSNTEQLGSLNDKLELVYNIL 249
XP_007374939 271 -----------SSSFnpdkDEEIKPILESLQKHLETISANTEPMLVFNEELEMLLNMl 317
CCE78463     437 ----------RSETYdpdnDIETKNALALVNRTLKKSYTKLSHLSKLNDELEELYNII 484
Q6BJB1       457 -----------NSNFdpnsDNDTQDVLQLIDKQLQSLSSDTTNLTTLNEKLETLYNFL 503 Debaryomyces hansenii
Q5A0H0       212 -------------DFdpetDDDTKFILETIQENL-----FQSKLKNLNDKLEVLCNVL 251 Candida albicans
XP_002547026 232 ------------YEFdpdqDEDTRAILEQLNKSLNI---STSDLKKLNGKLEILSSML 274
EMG50891     217 -----------MGEFdpdrDDDTKEILVKLNGSL-----NLMDLKKLNEKLEVMINML 258
XP_006683672 275 -------------RFtpreDDEVNELLEKLDSGLKRVSGNSKDLIDFHERLQNFQDSL 319
XP_001485277 257 -------------PFnpndDPETRQLLTEIRDKLAPLQEKCKELAEADDALDVLYNFL 301
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