6WSK


Conserved Protein Domain Family
CNRIP1

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pfam15043: CNRIP1 
CB1 cannabinoid receptor-interacting protein 1
This family of proteins interacts with cannabinoid receptor 1 (CNR1) and attenuates CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Statistics
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PSSM-Id: 464465
Aligned: 16 rows
Threshold Bit Score: 178.274
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WSK_A       186 LPGIVRLSIALRIQPNDGPVFFKVD-GQRFG-QN----------RTIKLLTGSSYKVEVKIKP-TtLQVENISIGGVLVP 252
XP_001632224   7 EERAFKTSLSLTRSEDSSPVFFKVD-GERFK-ET----------RTLKLQVDSKYKVVLEFRP-P-QTLAEAAISGGSLK 72 
EFX77636       1 -mgSFRLTLSLHKEPDNKPVFCKVD-GQRFA-QP----------RTVKFLADSKYRVDVNIRP-A-KTVRGIAVMEKSLE 65 
XP_011258964   3 ADGHFRVTLSLRREPGAGPVYCKMEtSARFR-QL----------KTVKLSCETTYRLDISFKP-P-QLLQSLSIGGKSVE 69 
ESO13198       1 msQHHKIQLSIVKKPYDRPIHFKVD-GKRFD-QE----------RTVKFNVNAKYIVNITVTP-P-LIIEQLTMMGAKLE 66 
XP_011444642   1 mssQLKVLLFLRQKEGGGGVCYKHD-GERFD-HP----------HTLKLNQDTDYI--ITVQS-P-LLLRDLMIQGEKYE 64 
EFO18918      19 staGFELQFNIRKYNTDEPITFKVD-GERFGkTQgrdvksdvllRTYKFRSEVIYKITVTTKP-A-TEFHVLHIAGSDLE 95 
XP_003110042   2 TKYAFTVELCVKEFSSGDPLAFKMD-GHRFDgAQ----------RTLKWSTDQTYAVKITTKP-A-TEVTRINVNGNDLD 68 
XP_002613149   3 SDFIFKVTVSIRREDDGSPVFFKID-GGRFKtSE----------RTIKLQADVQYRLDIDIKP-S-LYPKSTSLGTTSLQ 69 
XP_003456544   4 VPPIINISIALRIQPNDGPVFFKVD-GTRFG-QS----------RTIKLLTGSKYKIEVVLKPgN-VEATNMNIGGIVFP 70 
6WSK_A       253 LELKC---KepDG--ERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEY 327
XP_001632224  73 AELKK---I--DE--NCSVYEGLFSTQGMPSSKSKDRAYIVLSLKFNTGHEMNVQVQSKLYSVKDNTHVTWGACLKSLDF 145
EFX77636      66 VTDNSsklE--DE--NASSYSAQFQLDNLQPSKKGQRESVSLHVKVN---TFTTTLQIKIYKANSTQHCDWGTTVHSIEY 138
XP_011258964  70 AVERA---R--DS--TACAYSAYHSTKDISASARGHREDLSIAMRVLGSGYLTTCLQIKYYRLDDQSHCEWGARLHCIEL 142
ESO13198      67 VDEMKr--T--DE--EVAVFRAEMVTSGLTKDIKGSRQKFPIQIQFKNTGEMLTNFQCKFYGEHETQHTCWGNPLNHIEY 140
XP_011444642  65 LKEVRpetG--KKsdDNFRFSAVFNTSGFAVEKRNNRKNVTVVLMFDGEVTLTTLLQCKFYPQSETDHSRWGNALSWIEY 142
EFO18918      96 LRPESi---------GGGVYSTEWNTTGSDVTLNRKREYITVCLQG-PGRILQRKIQAKFYR-NDNSHADYGEKLEALIW 164
XP_003110042  69 VTKE-----------KLGVFSGNWNTAGAEVSKRGTRFPLIFLVNFAPEGQMRVEFQSKVYSKND-SHAVWGHKMNSVEF 136
XP_002613149  70 LKEQS---R--DP--HSVRYTTVWSTAGTSVSKKGSRQDVPFVMEFDGLGMLKVCLQCKFYKASDSDHCSWGDSFKQMEL 142
XP_003456544  71 LEQQS---R--DD--ESVVYHGQYDTEGVPHTKSGDRQPVQVSMEFIKAGTFETVWQAKYYNYYKREHCQFGNKFSSIEY 143
6WSK_A       328 ECKPNETRSLMWV 340
XP_001632224 146 ECKMRDGQSFVSI 158
EFX77636     139 ECHTDQQNNSIKI 151
XP_011258964 143 DCSSVEGR-LVTV 154
ESO13198     141 DVHLSEGRFIIEA 153
XP_011444642 143 DCRLTEGQSGVLI 155
EFO18918     165 KCAVDNTGNIAVV 177
XP_003110042 137 KCSGDDDG-YVKI 148
XP_002613149 143 NCTLTEERTFIKV 155
XP_003456544 144 ECKPNETRTLMWI 156
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