Conserved Protein Domain Family
Coq4
?
pfam05019: Coq4 
Coenzyme Q (ubiquinone) biosynthesis protein Coq4
Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).
Links
?
Statistics
?
PSSM-Id: 461522
Aligned: 105 rows
Threshold Bit Score: 220.43
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q4DBV7                         15 AASSLPAFVAATTRSIWDPVNADDVAAVGEITALTALGHMKQSMMSDRTGRMILRTQ-PRVTDETL-----------EFA 82  Trypanosoma cruzi strain CL Brener...
WGS:AAGF:cds.TTHERM_00275760A  56 NAERLLLVAKNAINAFIYNAQGQHLSNLGCLTSYSTLQEVRERMMKDEVGRQILLEK-PRINHDSA-----------NIE 123
A0DUC3                         15 NFERLSTLFQCAINAYKYPLNGNHLSQLGELSGYYCVKDIHQRMLQHPVGQRILIDK-PRVTPETF-----------KVE 82  Paramecium tetraurelia...
Q382H9                         19 AVKSLPAFVTSSFGAIVDPEDGRGSAAFAEITALTALHHMQRLMMADEMGRSILKER-PQVTDETL-----------EFA 86  Trypanosoma brucei brucei TREU927...
XP_002958516                    5 PLQKGAVALLSAFGALMRPARADLVAAVGETTGEWLLPSIRDRMRRDPVGERILAER-PRVTDATL-----------ALC 72 
XP_005843392                   45 GLEKGAVALLSLWGAFRDPRRGDLVAASGETTGLPAIYAMRERMRRSETGRRILQDR-PLITDEVV-----------APC 112
XP_002505896                    1 mLQKSLLSVAAGVGAVAFPHRADLVGAVGETTGWYALRRMRDRMRRDPTGRDILRRR-PRITDDFL-----------ERC 68 
Q01EJ8                         11 TLPKFLLPSAAAFGAMVRPERADLVGVTSETVGVFKYKQLLSQLSADRESQNVLQGQvSKISKHALl------------- 77  Ostreococcus tauri...
jgi:OSTLU_119511               10 MLPRVLLPTLAALGAILHPERADLVGITSETIGVFKFERILSQLLQDRNGRAMLRDR-QRISEHSLl------------- 75 
EED88476                        4 PLQRLATLLHSSITALNDPTRADAVAAVGEVTGSYALSRMMQTMQNDEIGRRILKER-PLVNETVAerafrlleqhnNMN 82 

Q4DBV7                         83 S--R--QPPG---TFG--------HRYAQFMKFNRFTPNGRTPVAHIADPTLAYVMQRQRETHDFLHTCIGCGRTVEEEI 147 Trypanosoma cruzi strain CL Brener...
WGS:AAGF:cds.TTHERM_00275760A 124 YllS--LPKN---TFG--------YHYGRFMGDRDFSSEERPKVTYMPDFELAYIYQRYKEIHDFIHTLLGFDVTVYDEI 190
A0DUC3                         83 EllK--LNQN---TFGqhssliqsYQYGKFMRDRDFSSSERPIVKYIPDLELAYVYQRYKEIHDFIHVLLMYDVSVYDEI 157 Paramecium tetraurelia...
Q382H9                         87 K--T--QPEG---TFG--------YRYAAFMKRNNFLPSGRAPILHVSDPTLAYVMLRYRQIHDFVHAYVGLGRTIEEEL 151 Trypanosoma brucei brucei TREU927...
XP_002958516                   73 R--D--MPPG---SFG--------AAYAKFMGDRRFSADERPPVRFLDDEELAYVITRAREVHDFWHVLFDCHTNVFGEL 137
XP_005843392                  113 W--D--MPQH---TFG--------GAYARFMGTRGFLASGRPPCRFVDDPELAYIITRARQVHDFWHVIFGCHTNAFGET 177
XP_002505896                   69 H--A--LPEG---TFG--------GAYAKFMGRRKFNPNDRPPVRFVDDEELAYVATRSREVHDLWHVLFQCPTTVQGEL 133
Q01EJ8                         78 --kArlCERG---SLG--------HAYASFMDSRMFEPSDRPPVRFLADGKSQLIAVRMREIHDILHVLFDCPTTLRGEL 144 Ostreococcus tauri...
jgi:OSTLU_119511               76 --kArlCERG---SLG--------HAYAKFMDSRQFEPSARPPVRFVQDKQSRYIAIRLREIHDILHVLYDCPTTLKGEL 142
EED88476                       83 ElkS--TANNnsmTFG--------AAYATFLQTHNFDPNERSPIRFITDPNLSYVMTRYRQCHDYWHALTELPPTVLGEL 152

Q4DBV7                        148 IVKLLEWRHTGLPIGLLA----VIGSLpWLSRQQIRN-MELYFEWAEVNAPNQRhgEVnipyiTNVWWEYYLDKPYEQLL 222 Trypanosoma cruzi strain CL Brener...
WGS:AAGF:cds.TTHERM_00275760A 191 VVKWYEMVQLGFPSTGLSs---FVGPL-KFSQEEITRfNTEDLPMIIQQAKQSQ--FI-----MNIYFEKEFETNIHDLR 259
A0DUC3                        158 VVKWYEMAQLGLPSATLSa---FVGSF-KLNCQEKQKlLET-LPEILKRANRSE--FI-----MNVYFEEHINTDLTQLR 225 Paramecium tetraurelia...
Q382H9                        152 AVKLFEWQHTGLPVGLMA----VLGGMpWLRMDQILN-MGMYNEWARANAPRQLhgKRfvsciLNVPWEWYLDKPYEQLV 226 Trypanosoma brucei brucei TREU927...
XP_002958516                  138 ALKGLEFVQTGLPMTGLAv---LGAQY-RLNSADRELlQRHYLPWALRAGSRCA--DL-----MCIYYEKHFQDHLEDVR 206
XP_005843392                  178 ALKAVEFVQTGLPMTGLAv---LAGEW-RFRPEDRRLlNEQFLPWAVRAGARAP--DL-----MCIYYEEHFGESLEELR 246
XP_002505896                  134 ALKALEFAQTGLPMAALGa---AFAPI-LLETSKREFlFNEMYPWARRAGARAA--DL-----MCLDYENEIGTDLAELR 202
Q01EJ8                        145 TLKAIEFVQYGIPAHWASt---YFASS-RLNHEEQYFlATKLLPWAVRAGCTAS--RL-----LVIDYEEFFPEQIDHLR 213 Ostreococcus tauri...
jgi:OSTLU_119511              143 TLKAIEFVQYGLPAHWASa---YFAPS-RLPLAERNFlTNQLFPWAIRTASKAP--NL-----LSFDYESLFHTPIDQLR 211
EED88476                      153 ALKWVELMQTGLPLAALSatggAFGAS-GLSEEEREIlWSVYFPWAIRVGQNMKgnAL-----MCVYYEEEFETDLGVLR 226

Q4DBV7                        223 ADTGITPID 231 Trypanosoma cruzi strain CL Brener
WGS:AAGF:cds.TTHERM_00275760A 260 KRLGLTLdp 268
A0DUC3                        226 KSLRll--- 231 Paramecium tetraurelia
Q382H9                        227 DDVGIVPLD 235 Trypanosoma brucei brucei TREU927
XP_002958516                  207 REHRIIPAP 215
XP_005843392                  247 LRWRIEVAP 255
XP_002505896                  203 HKWRITPAP 211
Q01EJ8                        214 SAWGIQVVP 222 Ostreococcus tauri
jgi:OSTLU_119511              212 DDWKIERIP 220
EED88476                      227 DRIGIEPAP 235
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap