Conserved Protein Domain Family
Got1

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pfam04178: Got1 
Got1/Sft2-like family
Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.
Statistics
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PSSM-Id: 461210
Aligned: 246 rows
Threshold Bit Score: 30.1519
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBN78912      46 LIGYGA-CLAVGFCLTFGsLFRVaqlltgNPRPFVLYFSLGSALNICSSFFLTgpwkQIKKMF-NPVRAVATSIYLATLS 123
Q9USJ2        13 TTALGFlFMIMGIFMFFD----------------GPLLSLGNLLLVFGFFMIAgfskSVS-FFlRKDRMLGSISFFSGLL 75  Schizosaccharom...
EPY50587      13 VTSLGLlFMVLGVIMLFD----------------GPLLSLGNILSVSGVFMIIgpskSAN-FFiRKERMLGSISFVGGFL 75 
Q389A1        17 LTSLGVfFNFIGIVMFLD----------------SVLLTMGNVLFVAGIALVMgpsrFKS-FFlFRR--RASCCFFIGML 77  Trypanosoma brucei
EPR80124      49 MIAFVS-CMVVGVLCFIY-ALFNipsavfRPSKFAFPYAFSNFLFFMMIGFIFgfrtYFKNIM-SKKRKAYTIAFLCSTL 125
XP_008075471  52 LGCFFV-FLVAAFLSFIY-SLFNilgaivSPAKFALPYAFSNFLFFTMIGFLVgfrkYFKSTF-SQNRWRYTTTFLVCTF 128
XP_002996516  45 AVAFII-FFVIGLLSFFY-AMVKvftaviYPAQFALPYAFSNFVFFFMFGFILgfrsYISNLF-SEKKRVYTSFFILSTF 121
Q8SQN0        46 AVCFSA-CLGAGVLSFLY-SMIKiv--rlSPSGFILPYTISNFLFFIMFGFLLgfrsYLEGLF-SKKKRVHSSWFIGCTL 120 Encephalitozoon...
EOB12152      47 AICFIV-CFGIALLSFFY-SMMRiftavlYPAQFILPYALSNFLFFVMFGFLLgfksYFTNLF-SEKKRTFTSFFIVCTL 123
XP_007604526  50 IMAFVI-CAVVGLLLFFT-SLYRvmfiaiNPTGFVAPYVLSNILFFNMFGFLSgfktYFSRLF-SKEKKGFTIAFIAVTA 126
CBN78912     124 ATLF----VALSPYASVpfrgiLLLCLVVAQFLSYVWYTLSYVP 163
Q9USJ2        76 LTLFhfpiIGFFVECLG-----FFNLFK--VFYPLIISFLRTVP 112 Schizosaccharomyces pombe 972h-
EPY50587      76 LTILrfpvLGFFFECLG-----FFNLFR--VFYPIIISFLRSLP 112
Q389A1        78 LIMLgrslIGLMIQGFG-----TLNLFG--NFFPMVARVLESVP 114 Trypanosoma brucei
EPR80124     126 LTLY----VAVKVHSYI-----INFFMMIVQLCSFLAFMVSFIP 160
XP_008075471 129 LTIY----SAMKIKSYF-----FNFTMAIMQIGSFVVFAITYLP 163
XP_002996516 122 TTIY----TTLTMGHYF-----INLLFCVIQVISFIIFAITFIP 156
Q8SQN0       121 LTLY----VVLKYDRYL-----LNLAFCFIQVVSFIMFSLTFIP 155 Encephalitozoon cuniculi
EOB12152     124 LTLY----SALSIKSYF-----INLSLCVLQICSFVIFSLTFIP 158
XP_007604526 127 VTMY----SAFILKRSL-----YVFCFGIVQIFTFVMFLATFVP 161
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