Conserved Protein Domain Family
STIMATE

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pfam12400: STIMATE 
STIMATE family
STIMATE is a ER-resident multi-transmembrane protein that serves as a positive regulator of Ca(2+) influx in vertebrates. It interacts with ER-resident Ca2+ sensor protein STIM1 to promote STIM1 conformational switch. This entry also includes budding yeast YPL162C.
Statistics
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PSSM-Id: 463561
Aligned: 107 rows
Threshold Bit Score: 96.7901
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH60636                      115 CDWYFLNLLLDTTIGIPILWFLLNCIHYIFQYLN-IKNIESGNYFpsledydtnlimhhtiagnnigmlgddnciitast 193
CBJ27007                       93 CAMYFVNFSLDIAIGTFMIWCFVRVQELTAVRCGiDSLKVTGDYG----------------------------------- 137
2_pfamImport                    1 CALYFVNFTLDTTFGVVLNYFLLSGLAFLALRLSwSALQTTGDYG----------------------------------- 45 
EEY69815                       93 CALYFVNFTLDTTLGVFLNYVLLSAVVLLALRFSwSSLKTPGDYG----------------------------------- 137
XP_002904052                   85 CAWYFLNFLSDCTLGMIVSLAFLRLQQELAFSMNwVNIQESGEYG----------------------------------- 129
EEC46631                      136 CAWYGMSYLIDTTLGLVLAIFFLGVLDKLASERDwVHLKHSGVYsgp--------------------------------- 182
EED94644                       97 CAWYAINYVIDTTLGLVITIFFLNALEKVANDRDwTSLKNSGVYvgr--------------------------------- 143
WGS:AAGF:cds.TTHERM_00056080A 135 CNYYFVTVVIDTSCGVFLACFLLLQLDNLLKRKG-CENLRTGNYYketkv------------------------------ 183
Q23H86                         72 CNWYFVTVLFDTTLGVFICFIILSIFEKLFDRYH-LVKFKTGNYFkviipdn---------------------------- 122 Tetrahymena thermophila SB210...
XP_009536481                   82 CAFYFMNVVIDTTLGVYIAYLLLQLFTLVATRQQwTSLRCHGYYG----------------------------------- 126 Phytophthora sojae...
CCH60636                      194 nnilhsRr-------------Pm---------FKAFLIQLSIYSSGLLLMKSVVFLILNYFEEfSYWFANLMLGWSDSWP 251
CBJ27007                      138 ------T--------------Pp--------lFSVYRTQLLAYTVILVICKAVTTAIVIAMDEvLSSLAKALFSPVSAYP 189
2_pfamImport                   46 ------M--------------Pv--------qVRTWLLQVLSWIVVIFTCKMMIAAVILAFQQpLGALAVLLFKPLEKYP 97 
EEY69815                      138 ------T--------------Pv--------rVRTWILQVLSWILVIFTCKFLIALLIVAFQKpLGAFAVLLFKPLADHP 189
XP_002904052                  130 ------N--------------Pp--------sYRVWAMQLIAWLVIIVISKAIVVSVMIAAATpLGFLGELLFHSLRGYP 181
EEC46631                      183 ------------------------------dgVLHWISQCLAWLVILTVVKVIIYIFMLAGGSwLAWIGGVLFAPLQGNI 232
EED94644                      144 ------------------------------egIIHWMHQMVAWIIILTLVKVVICVFMWITAApLAWIGAILFEPLQSNI 193
WGS:AAGF:cds.TTHERM_00056080A 184 --fkkrTivdenq---nimniPmedvnyieidYLTWLIQLAIWLTLTFISKMILFFVQALLKYpLGLASYFLLYWLNSMP 258
Q23H86                        123 gsgqktKkksredesnihllkPivk-----isYCVWLSQLIIWNLIVVISKFFLYGLQSGISPyLQPIISWMFSFLESFV 197 Tetrahymena thermophila SB210...
XP_009536481                  127 ------S--------------Pp--------sWRVWWMQLLQWCAILTIMKVFVGGVLYAFSTpLGWVGSLLFYPVHNHP 178 Phytophthora sojae...
CCH60636                      252 NFQVFLVMFICPIVLNCFQILCIDSIIK 279
CBJ27007                      190 ELELTLVMIICPWILNALQFWILDNVLM 217
2_pfamImport                   98 DVELVLVMIACPCLMNAVQFWIQDSFLK 125
EEY69815                      190 DVELAIVMIACPCLMNALQFWVQDNFLK 217
XP_002904052                  182 FAELVLVMIVCPSFLNVVQFWIQDSFLK 209
EEC46631                      233 RFELLFVMIFFPGILNVIYFWIADGYLK 260
EED94644                      194 RFELLFVMIFFPGFLNIIYFWITDSYLK 221
WGS:AAGF:cds.TTHERM_00056080A 259 VVKLVFVMIIIPTIMNGMQFWIQDNVLK 286
Q23H86                        198 KLKLIIVMVIVPAILNAIQFWIQDNFLK 225 Tetrahymena thermophila SB210
XP_009536481                  179 KIELLIVMIGCPLVMNMVQFWIQDSFLM 206 Phytophthora sojae
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