6WXU


Conserved Protein Domain Family
DuoxA

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pfam10204: DuoxA 
Dual oxidase maturation factor
DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane of thyroid follicular cells, essential for iodination of thyroglobulin by thyroid peroxidases. DuoxA carries five membrane-integral regions including a reverse signal-anchor with external N-terminus (type III) and two N-glycosylation sites. It is conserved from nematodes to humans.
Statistics
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PSSM-Id: 462995
Aligned: 34 rows
Threshold Bit Score: 302.97
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6WXU_B        10 FYTGTKPTFPMDTTLAVIITIFLTALVTFIIILPGIRgKTRLFWLLRVVTSLFIGAVILAVNFSSEWSVGHVN-ANTTYK 88  house mouse
XP_008191435  17 YSFNNRTAVTGDVTLITFLTIFSTLYVAFLIIFPGIR-KERFTTFFAVTLSLFVGATILVTLFGSAWHVATAS-IVSTYR 94 
XP_011259247  17 YSYSNRTPVTGDVPLVIIFVIFGTLFTAFLVIFPGIR-KERLTTFLTVTMSLFVGATIQVAQYGSSWHTSTAT-IVSSYS 94 
3_pfamImport   1 YNVPNRTAVTGDVPCIAACLAFITLYIAFLIIFPGVR-KERFSTFSTVTLSLFAGNVIMVCRMGSSWHIANTK-ILSPYS 78 
XP_001949862  13 YGYSNRTPVTGDVQMITTCLVFGTIFTAFLIIFPGVR-KERFTTFTTVTLSLFVGNVILLSILGSSWHVAETV-ITSAYR 90 
Q171Q5        17 YSFSNRTPVTGDVSIVAVCVLFATIYLAFLVIFPGVR-KQKFTTFTTVTLSLFVGLVILVTRLGSGWHVAQST-IVAPYK 94  yellow fever mo...
Q9VJQ7        17 YSFSNRTPVTGDVSIVAVSVLFATFYVAFLVIFPGVR-KQKFTTFSTVTLSLFVGLVILITRLGSAWHVAHAT-IIAPYK 94  fruit fly
OWR42211      17 YAYHNRTAVAADVPAVALLVAALTLYLAFLTIFPGIR-KERFSTFTIVTLSLFVGTVILVCKHGSSWHVAGARvARAAYR 95 
EEC00946      21 YMSDNRTSVSADPAEVLVYLAFVTLLVAFLAVVPGIR-KERCTTVFCVSSSLLVGAAILIGVHGTSWHVGRGQtV-TYYR 98 
EFX87619      17 YDRANRTAVTGDVSTITFCVIAITLFVAFLIVLPGMR-KERFTTFTSVTISLFVGAVILVTGNGCGWHTGEGQ-ITSSYR 94 
6WXU_B        89 AFSPKWVSVDVGLQIGLGGVNITLTGTPVQ---QLNETINYNEAFAWRLGRSYAEEYAKALEKGLPDPVLYLAEKFTPRS 165 house mouse
XP_008191435  95 AFSTDKLSSNIGVYVGLRHVNITLQASGGH---NWTSDIDFNEQFLWINSDQMGDSFREAMVRGLPFPILTVAEYFTMGQ 171
XP_011259247  95 AFSRHKAMADIGGYIGLMHINITYKLLPENeqtNS--DVEYNERFWWRSSGEMTSAFKQALYQGAPFPIVSLAEYFSLHQ 172
3_pfamImport  79 AFSKELLSAELGAYIGLTHVNITL--LGEQhwkQ---QIDFNERFTWRGSGEMGESYKAGLERGLPFPILTVAEYFTLGQ 153
XP_001949862  91 ALSKELITAELGAYVGLGHINITLCAMPSDnssVPLEDISFNERFSWLGAHEMGESYQAALYRGMPFPILTVAEYFSLGQ 170
Q171Q5        95 AFSREKLPARLGAHIGLMHINITLAALPVGnwsTP--DIDFNERFSWNQANDMGNSYKNALQRGLPYPILTVAEYFSLGQ 172 yellow fever mo...
Q9VJQ7        95 AFSREKLPARIGTHIGLMHVNVTLTAIPIGnwtPP--DIDYNERFTWEGANDMSANYRHALQRGLPFPILTVAEYFSLGR 172 fruit fly
OWR42211      96 AFSAERLDCWLAVHVGLGHVNVTLNALSWGnvsTGDPGIDYNEQFRWEEAGAIQEWYRAGLLRGLPYPVLSVAEHFAAEH 175
EEC00946      99 AFSRERIPARLGVYVGLSSVNVTYAAVVENarsNETLDINFNEEFWWPKPTSLRKEYYDALVKGLPFPILTVLDYLSQDS 178
EFX87619      95 AFSNEKIIAKLGIHIGFNHVNVTLRSAGVFnlsD---RIDYNERFGWRGPDDMVNEYHKALHKGLPYPILTVAEYLSLNE 171
6WXU_B       166 P-CGLYNQYRLAGHYASAMLWVAFLCWLLANVMLsMPVLVYGGHMLLATGLFQLLALFFFSMTtslISPCPLRL--GTAV 242 house mouse
XP_008191435 172 EgLSWGGQYRAAGYYAIIMLWTSFSVWILMNLML-IVVPRYGAVLMTTCGFLLLATACGYFGL---LPETPLVVhiEGST 247
XP_011259247 173 EgFSWGSQYREAGYYASIMLWTSFASWLMMNLLL-MVVPRYGAYSMILTGLCMLLTNLIYTSL---LPCEPLIAhiDGSI 248
3_pfamImport 154 EgFTWGGNYRHAGYYASILLWTAFASWLVMNLLL-VVVPRYGACAMVLTGCLMLASTLVYHCL---LPVRPLHVkfEDTT 229
XP_001949862 171 EgFAWGGQYRAAGYYGSIFLWTAFVLWFLMNILL-IVVPRYGAYTMIGMGSFMVGATVAYHSM---LPSSPLVIrfQDDK 246
Q171Q5       173 EgFAWGGQYRAAGYYASILLWASFASWLLMNLLL-VAVPRYGAYTMTLTGALLIGASIGYSQM---LPKRPLTIfiEGGR 248 yellow fever mo...
Q9VJQ7       173 EgFSWGGQYRAAGYFASIMLWASLASWLLMNLLL-IAVPRYGAYMKALTGALLVCTTVGYHCL---LPKRPLSIhlEGGR 248 fruit fly
OWR42211     176 EgFEWGAKYRAAGYTTATLLWTALALWLLMNLLL-VVVPRYGAYAMASLGVTLCAAAGGYWAS---LPHAPLVVrlDGAM 251
EEC00946     179 GgFLWGRMYRAAGGWAQLFLWASFAAWLLANVLL-CAVPRYGTYTLQLTGALMVVSTIIYSSL---LPDLPLVIplEGDF 254
EFX87619     172 EgFGWGRTYRQAGYYSCIALWASFAAWLLMNILL-VTVPVYGGYMMLLTGGLMLLSNLIYFIN---VPSRPLLIrfEDTI 247
6WXU_B       243 -LHTHHGPAFWITLATGLLCILLGLVMAVAHRMQPHRLKAFFNQSS 287 house mouse
XP_008191435 248 -LHFSFGWCYWLVLIAGSICLLSGVIITVLEIIFPHSFSTILEVDY 292
XP_011259247 249 -LSFNFGWNYWLVLSAGAACLLAGIVITAIDMIFPHQFSTILEVDY 293
3_pfamImport 230 -LSFRFGWCFWLVVVAGALCILVGLIILTIDLIYPNRFSTILELDY 274
XP_001949862 247 fLLFRLGWCFWLTLFTGLLCISVGLIIVAIDCVYPHKFSTILEVDF 292
Q171Q5       249 -ISFRLGWCFWLVLIAGILCLSVGLIISIIDLVWPHRFSTILEVYY 293 yellow fever mosquito
Q9VJQ7       249 -LEFHFGWCYWLVLVAGILCFIAGVLISIIDLVWPHTFSTVLEVYY 293 fruit fly
OWR42211     252 -LFFSMGWCFWLVLIAGAICLVVGLLIAALDLVWPHRFSTVLEVDY 296
EEC00946     255 -LQLSMGWNFWLVLIIGILAIILGGVMALVDILYPSKFPTVLEVDY 299
EFX87619     248 -ISFTYGWCFWLVLAAGLLVSLLGLIITLVEIAYPHKFSTVIELDY 292
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