Conserved Protein Domain Family
bHLH_TS_LYL1
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cd19705: bHLH_TS_LYL1 
basic helix-loop-helix (bHLH) domain found in protein lyl-1 and similar proteins
Lyl-1, also termed Class A basic helix-loop-helix protein 18 (bHLHa18), or lymphoblastic leukemia-derived sequence 1, is a proto-oncogenic bHLH transcription factor involved in T-cell acute lymphoblastic leukemia. It plays an important role in hematopoietic stem cell function and is required for the late stages of postnatal angiogenesis to limit the formation of new blood vessels, notably by regulating the activity of the small GTPase Rap1. LYL-1 deficiency induces a stress erythropoiesis.
Links
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Statistics
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PSSM-Id: 381548
Aligned: 4 rows
Threshold Bit Score: 129.366
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens SCL (2YPA):E47bHLH heterodimer binds DNA.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #   # ### #    #                 # ##                      
P12980       146 PQKVARRVFTNSRERWRQQNVNGAFAELRKLLPTHPPDRKLSKNEVLRLAMKYIGFLVRLLRDQA 210 human
XP_024272561 143 PQKLARRVFTNSRERWRQQNVNGAFSDLRRLIPTHPPDKKLSKNEILRLAMKYIDFLVTLLNDQS 207 Chinook salmon
XP_006262407 140 PHKVARRVFTNSRERWRQQNVNGAFAELRRLLPTHPPDKKLSKNEILRLAMKYIDFLVRLLRDQA 204 American alligator
OCT56767     181 PQKVARRVFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMRYITFLVTLLGDQR 245 African clawed frog

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