Conserved Protein Domain Family
CT
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smart00041: CT 
C-terminal cystine knot-like domain (CTCK)
The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.
Links
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Statistics
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PSSM-Id: 214482
Aligned: 24 rows
Threshold Bit Score: 53.9465
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P70041        171 TLPFTQNIVHENCDRMv-IQNNLCFGKCISLh------VPNQ--QDRRNT-CSHCLPSKFTLNHLTLNCTGSKN----VV 236  African clawe...
Q20204       1334 KQKFRRHHIENECRSVdrIKIAECNGYCG--------------------GeQNCCTAVKKKQRKVKMICKNGTT----KI 1389 Caenorhabditi...
AAB71838      164 TVPFNQTIAHEDCQKVv-VQNNLCFGKCSSI-------RFPGegADAHSF-CSHCSPTKFTTVHLRLNCTSPTP----VV 230  house mouse
DAA34809     2727 ITARLQYVKVGSCKSEveVDIHYCQGKCASKa------MYSIdiNDVQDQ-CSCCSPTRTEPMQVALHCTNGSV----VY 2795 Sumatran oran...
AAD04919     2727 IIAKLQRVKVGDCKSEeeVDIHYCEGKCASKa------VYSIhmEDVQDQ-CSCCSPTQTEPMQVPLRCTNGSL----IY 2795 dog
BAC04860      489 VREQQEEITFKGCMAN--VTVTRCEGACISAa------SFNIitQQVDAR-CSCCRPLHSYEQQLELPCPDPSTpgrrLV 559  human
XP_855261      43 HYVDSISHPLYKCSSKm-VLLARCEGHCSQAsrseplvSFSTvlKQPFRSsCHCCRPQTSKLKALRLRCSGGMR----LT 117  dog
XP_002006867 1460 KEQVREYYTENDCRSRqpLKYAKCVGGCG----------------------NQCCAAKIVRRRKVRMVCSNNRK----YI 1513 Drosophila mo...
P38565        311 qgEYDYQNEKTNCSAN--IIMAKCSGQCQHKl------TYDTidNKVVTK-CRCCKADRVEPRKAHLVCDNGKK----KI 377  African clawe...
XP_002721415 2741 KVTIRMTIRKNDCRSNtpVNLVSCDGRCPSAs-----iYNHN--INTYARfCKCCREVGLQRRSVQLFCATNATw---VP 2810 rabbit

P70041        237 KVVMMVEECTCEAh-KS 252  African clawed frog
Q20204       1390 STVHIIRQCQCEPtkSV 1406 Caenorhabditis elegans
AAB71838      231 KMVMQVEECQCMVk-TE 246  house mouse
DAA34809     2796 HEVLNAMECKCSPrkcs 2812 Sumatran orangutan
AAD04919     2796 HEILNAMQCRCSPrkcs 2812 dog
BAC04860      560 LTLQVFSHCVCSSvacg 576  human
XP_855261     118 ATYRYILSCHCEecss- 133  dog
XP_002006867 1514 KNLDIVRKCGCTKk-CY 1529 Drosophila mojavensis
P38565        378 YKYKHITSCKCTSctay 394  African clawed frog
XP_002721415 2811 YTVQEPTDCACQW--S- 2824 rabbit
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