Conserved Protein Domain Family
Vps54

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pfam07928: Vps54 
Vps54-like protein
This family contains various proteins that are homologs of the yeast Vps54 protein, such as the rat homolog, the human homolog, and the mouse homolog. In yeast, Vps54 associates with Vps52 and Vps53 proteins to form a trimolecular complex that is involved in protein transport between Golgi, endosomal, and vacuolar compartments. All Vps54 homologs contain a coiled coil region (not found in the region featured in this family) and multiple dileucine motifs.
Statistics
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PSSM-Id: 462318
Aligned: 104 rows
Threshold Bit Score: 81.7966
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_004994290         830 EEHAAIGALLLFIKMLAEYCRCLDAM-PLAASDLLRKLFEILRSFNSQVRRLILQAEAMR-TLGLKR--ITAKHIALSAE 905 
EAY10366             481 SKFGVTASALTMLEIIWNYLEAARRI-KGTADDFTIKLAAAISNYSRQCMYYIYEGAAAK-QGKFKN--TSTRHLSLASA 556 
A0BQ00              2109 SKYKVTQAFLFFLQAISQYLHLFESY-SVINYEQTQKLVELIKCYNSLATQYILGAGAVH-FGKIST--ITAKNLAISSI 2184 Parame...
Q23QT8               773 QTYKLTSAFLQILKMIYEYLHLIDYF-KSMRETSSKKLIELLKFYNSYANELLIGGGAFQ--LGVQ---VSAVNLALSSV 846  Tetrah...
XP_001013161         816 KKYMFSEGFLVFLKQVQKYIGIMAESkIQYSKEYFIRFISLLRQYNTFSREFIVLAKGKNpQFPQMNgkVTVKNLATSSL 895 
EGG15358             689 EKFKIGNTTLMLLKFIDDYLNCIEKI-PMLAVDSIPKIAELLNTFNGITYQLVLGAGARQ-IMRTKT--ITSKHLGLTSQ 764 
WGS:AATM:SJAG_03963  732 DTFSCVATSSKLLHVLVDYARFASQV-PRFSSDCYASVLELYRVVNSRVYQLIMGAGAVR-SAGLPR--VLGKHIALAAQ 807 
O14093               708 QSLHIVRSSVTLLETLDDYGKLLAHF-SRLAPEFQTGMLDMFRTLNSRVYQLILGAGTVR-SSGLSK--VLGKHIALASQ 783  Schizo...
EPY51498             701 QSIHMVNASVRLLETMNQYGQLVYHF-PRLSHYLYYGMIDLLRTLNSRVYQLILGAGTVR-SSGLSR--VLGKHIALASQ 776 
XP_652343            573 ETYFMTNTMSILLPTLERYREIIIKF-PLLGECALSSAKDMLILYNNSMRRLILGKELIQ-KGVVQR--IGATMFTTTHQ 648 
XP_004994290         906 AIAVILAVLPSIKQRSAKL------VRDRSKSMLSE-FNSVQDEYARHQHDLLSKLTVIMED 960 
EAY10366             557 NIEFMARLISYITPRLETVg----aN----RNIVSVqMQNVSKNLIENENKLNTQICKVLTN 610 
A0BQ00              2185 CLRLFLYLLDPLSNKLFKVinqqqqTEFTNLQQIQNdFATIKVDYENHNAEVMAKLTTIVQD 2246 Paramecium tetraurelia
Q23QT8               847 CLQFALKIFPQMTERIIGLy----kEDRDLAENIEDqFSRLSDEYNNHNINIQKTISDILik 904  Tetrahymena thermophila ...
XP_001013161         896 NLTFLIKIFDKIKERLVQN------TDVSKEIIDAE-FQKIKIDIQNHISEIFGTIPNIIKD 950 
EGG15358             765 CLSFLVKLIPYLKTYLQRFl-----PSKNQYALLNN-FDKLTQDYTSHRSEIFSKFIDIVKE 820 
WGS:AATM:SJAG_03963  808 MIRFLQSSLKIMVQFLETT---------GGINPGLE-VEKLNRDFSFHLQQVQNKFVALMRE 859 
O14093               784 TIALFQLSLNSMCRYLSRV---------TGTRLTNE-TNKLDQDFTVHHLQIHDKFVSLMRE 835  Schizosaccharomyces pomb...
EPY51498             777 TVTLFQALSTSMVKFLSKY---------SGIRQTQE-LLSLENDFDLHHDQITEKFIALMKE 828 
XP_652343            649 TLLLLSLITPYLHHYLSPN-----------VIISGRiLDGIEDLMKAQCTDIRNALTIIVRN 699 
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