Conserved Protein Domain Family
ODC_AZ

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pfam02100: ODC_AZ 
Ornithine decarboxylase antizyme
This family consists of ornithine decarboxylase antizyme proteins. The polyamine biosynthetic enzyme ornithine decarboxylase (ODC) is degraded by the 26 S proteasome via a ubiquitin-independent pathway. Its degradation is greatly accelerated by association with the polyamine-induced regulatory protein antizyme 1 (AZ1).
Statistics
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PSSM-Id: 460445
Aligned: 54 rows
Threshold Bit Score: 72.6869
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE02693           195 WLelwdfaggasfrgflsEDVagSELSLFAFFDAHMLVnnGDLKMSLMALIELADSALGCAHLVVCVDRRAlplLEDAAs 274
NP_001295157       122 WR----------------AAL--KGRNLYVEIPPGSLP--EGSKDSFALLLEFAEEHLQADHVFICFHKSR---DDRAS- 177
XP_015198944       109 Weav------------------lsGGSLFLEIADGALP--EGSKEGLTALLEFAEEKLKVSYVFLWFKKSR---EDRLP- 164
NP_001291645        94 Wdav------------------lsNQNLFVEIPERGLA--EGSREGLTALLEFAEEKLKVDCVFICFCKNR---NDRVP- 149
XP_001639898       114 Wsaa------------------htKNCLYVQVPEGEIP--QGSKECFISLLEYAEEKLGCSHVFICLRKAR---EDRVP- 169
FlyBase:CG16747-PB 152 Wntil----------------npvNNLLYVALPKDLPP--AGSKQTFISLLEFAEEKLEVDGIVMVMPKDQ---PDRAR- 209
EEB10785            44 Wetv------------------lwNSVLYVQVPSCILP--GGSKEGFVGLLEYAEEVLHCGHVVVCMKKDR---TDRNL- 99 
EEC18673            80 Wetv------------------lcQGRLFVQLPSCALP--EGSREAFVTLLEFAEEQLGCDHVLVFFSKDR---PDRAS- 135
EFA06676            38 VL---------------------RGQTLYIALPPHVLP--EGSREAFVALLEAAEEQLKCQHVVVVFESER---PDRAM- 90 
NP_001037028       170 Weav------------------vhNNMMYLRVP-GVLQ--SGSKDSFMLLLDFAEERLGCKSCIICVLKSR---PDRAT- 224
EPE02693           275 LMKGLQWAGFSLTTLDAWTggegvDVTSQNWVFMGMEL 312
NP_001295157       178 LLRTFSFLGFEIVRPGHPLi-----pSRPDAFFMAYSI 210
XP_015198944       165 ITRTFHYLGFEIVKPGHPLvp---thPDI--MFMVYSL 197
NP_001291645       150 LLKTFNFLGFEIVKPGHPSvp---nrPDV--LFMVYPI 182
XP_001639898       170 LMRTFMFMGFETVVPGHFLcp---knEDY--IFMAYTI 202
FlyBase:CG16747-PB 210 LIEAFLFMGFEPLSRKAPQap-paAINDNENYYFLYSI 246
EEB10785           100 LVRTFMFLGFIPLAPGHVLip---snTDPANLFMLYSi 134
EEC18673           136 IVRTFMFLGFTTLTPGHRLvp---psASEGVLYMAYAI 170
EFA06676            91 LVRTFMFLGFAVLSPTSPLv---pPSLSSGHVCMLYNI 125
NP_001037028       225 LLRTFMFMGFQVLAPNSPLtp--qhINNPNYIFLHYNM 260
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