Conserved Protein Domain Family
Hep_59

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pfam07052: Hep_59 
Hepatocellular carcinoma-associated antigen 59
This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 (HCA59). Family members are found in a variety of eukaryotes, such as fission yeast where telomere length and silencing protein 1 (Tls1) is required for telomeric heterochromatin assembly as well as telomere length control. Homologs in Arabidopsis are known as Cop1 suppressor 2 (CSU2). Csu2 inhibits constitutive photomorphogenic 1 (COP1) E3 ubiquitin ligase activity. Furthermore, CSU2 is required for primary root development under normal light growth condition.
Statistics
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PSSM-Id: 462074
Aligned: 81 rows
Threshold Bit Score: 40.809
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KLU87494     144 RFSAQTG-LVVelVNRHMDEYIESELARrqaaedaakekAAgggggggglslfsrsghqarqqqqqQqqqqqsslmSRWA 222
EPY54186     105 RFAKPTN-EID--VNLHLVSYIESKMNQdr-----------------------------------qGshhyeknekISNE 146
EPS45610     129 RFTGQTG-AIVd-VNEHMMKYIESELAKrrmdd-----------------------------------------isqpmP 165
EFQ28842     145 RFAPQTGtAAAtiVNKHMMEYIESHLSNrkspvtqsttnPPssal----------------------------ttsQSSA 196
ENH77028     124 RFAPQTG-LTTtvVDKHMMEYIESRLSNrkssqppsqitSPsrph----------------------------pygGGAS 174
XP_003659522 133 RFAPQTG-LVGelVNKHMEEYVESELARrkrhaaeaaaqQQqqqqqm------------------------eqrgrEELT 187
XP_003652067 132 RFAPQTG-LVGelVNKHMEEYVESELARrmrhaaeaaaqQeaqer---------------------------qqmhSGST 183
Q2HAH5       131 RFAPQTG-MVGelVNKHMEEYVESELARrkrhaaeaaaqQqqldg---------------------------ewreDSVP 182 Chaetomium glob...
EHY58186     111 RFVSSTGqAIN--VDQHMVAFIDAELAR-----------RRnrtv------------------spsNdaqqqntekDSEV 159
EKG17823     149 RFAPQTG-RVAdtFDKHMMAYIDSKMAEmregeraaaaaAAaaa-----------------------------aaaAAAS 198
KLU87494     223 SPSGSVGLDDqaapgvTAlRGE------------GLQQPA-------------LRGKLQEVDLGQEMRSRNVALTQRATM 277
EPY54186     147 VIPKNDTSHEdsssivLG----------------LTNERKkn---------paALGAIQEVDVGITS--TNLESSRASKs 199
EPS45610     166 TSDESDSDLKrvypapLT-STKiserrigkwpirPDFRGA-------------TLGKLQEIDLGAESTRKNVERTEEAKR 231
EFQ28842     197 SASSIAPPPPppppppLPtTDPg-----------PKNHPI-------------MQGKLIEVDLGDEARARNKAMTEKAAR 252
ENH77028     175 SSRSQPHEPQ------------------------PKNQPI-------------MQGKLMEVDLGDEVRARNQAMTELAAR 217
XP_003659522 188 SNAADGQLGSrlaapgGQ----------------NDSQRV-------------LQGRLLEIDLGDEARARNIEMTERARR 238
XP_003652067 184 TSTTDGQPGPssagpdGQ----------------ADSQRV-------------LQGRILEIDLGEEARARNVAMTERARR 234
Q2HAH5       183 SSTGDGQPATsstapgQ-----------------GDSQRV-------------LHGRLLEIDLGDEARARNIEMTERARR 232 Chaetomium glob...
EHY58186     160 ETPPDKPHTE------------------------STIQSAsatsnvptlshpaTVRQLTEVDLGDSAHEINLARIQAAle 215
EKG17823     199 SNGTSNRDYDrsfgatNSaSMPm----------sIERQPA-------------GMGKLMEIDLGPEAAQRNIERTAEATR 255
KLU87494     278 K 278
EPY54186     200 k 200
EPS45610     232 R 232
EFQ28842     253 R 253
ENH77028     218 R 218
XP_003659522 239 R 239
XP_003652067 235 R 235
Q2HAH5       233 R 233 Chaetomium globosum CBS 148.51
EHY58186     216 r 216
EKG17823     256 R 256
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