Conserved Protein Domain Family
Trm10_MRRP1

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cd18102: Trm10_MRRP1 
Mitochondrial ribonuclease P protein 1
Mitochondrial ribonuclease P protein 1 (or tRNA methyltransferase 10 homolog C) functions in mitochondrial tRNA maturation and is part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. MRRP1 is related to Trm10, a tRNA m1G9 methyltransferase and is a member of the SPOUT (SpoU-TrmD) methyltransferase (MTase) superfamily, a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Statistics
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PSSM-Id: 349975
Aligned: 44 rows
Threshold Bit Score: 168.87
Created: 15-Aug-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
SAM binding
Feature 1:SAM binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
Q7L0Y3       203 QPLVFDMAYEnymkRKELQNTVSQLLESEGWNRrn----vdPFHIYFCnlkidgalhr--------elvkryqekWDKLL 270 human
EEC20112     207 QSLVFDMGYDdqmtPRECNKAVIDLKAVYSRNRfs----rdPFHLHFCnanpkhrtte-------llhntlfkpaKHTTL 275 black-legged tick
XP_015786882 219 QKLIIDFSYEncmhTQEKKSLVKQLCFGYQKIRes----edPFDLWFCglnpkekthsyl----devlgwnrnaiFTNSF 290 two-spotted spi...
XP_002125461 250 QPMIVDMDFEt---YSNVGDMYKQLSKVIADNRrl----chPFNVIMAnhrkdnelsa-------wsktdffrnnDNSAY 315 vase tunicate
XP_013411013 209 QPLLIDLGYDslmtHEEKKALSIQLGYIYHDNRes----rdPFNLMLChassdsesty--------sigvqkgilQPSWM 276 Lingula anatina
CDS25339      66 QTLVFDCSHEeemrISDQKNLARQLAMAFANNRtqr---pfPFHFMFTslvpgtnqykffeeafgtgvssnrcnsLEMCP 142 Hymenolepis mic...
EKC22642     156 DPILVDLGYAdmlyYNEIIDVARHLFLSIGDINrsalnhtpTFNVIFCnvkpsveeneil---ktmrrlltedcsMSKLP 232 Pacific oyster
XP_003742689 135 QRVAVDFSFDdlmsPREMRKLSVDMKLMFAANRwt----tsPVNLHLCsfdpetsfsa-------rlvtnmvaarKLAFP 203 western predato...
XP_015790579 227 PKLVIDCDYEl--sIIETRKIVWDIFYAIKAVSkq----tfPFNIMLTgpfseackktm-----kqtmisndpelGYLGA 295 two-spotted spi...
XP_015790590 232 QKILIDCDYEy--tVGDAKRIIFDLQKAMALNRsa----ssPFNMVVTglrdtmlrel--------ldrhkkeclSTLLP 297 two-spotted spi...
Feature 1                               ###                  ## # #                      ## #    
Q7L0Y3       271 LTSTek-sHVDLFPk---dSIIYLTADSPNVMTTFr--hDKVYVIGSFVDKSm--QPGTSLAKAKrlNLATECLPLDKYL 342 human
EEC20112     276 SEVTer-sYLDLFPk---eKIVYLTPEGKETLDVFd--hDAVYVVGVLVDKDt--KEGATFAKAIqeGVRTMRFPHTFTL 347 black-legged tick
XP_015786882 291 IHRTer-sYLDLFPk---eKLVYLCPDSSVDLHKFd--dEAIYIVGGLVDKRv--IKPVSLAKCKkeGLKTARLPLDQHL 362 two-spotted spi...
XP_002125461 316 LNVTek-sYLDMQPlinpeSLIYLTPDASEYMTEFq--hDKVYIWAGLVDKIp--QAGLTKTKAHseKIKCERFPLELYL 390 vase tunicate
XP_013411013 277 WSVTgr-dMVDLYPr---kSLVYLSPDATDYLTEFd--pNAVYVIGGLVDKNv--SKKLSQRKAQnrGVASVKLPIDQYK 348 Lingula anatina
CDS25339     143 FSVRpd-hFSEVIKd---rRLIYLSPNAPRAFEIGeydhDAVYVVGGIVDKAv--RRPVTHAKARraGWECIRLPLERYV 216 Hymenolepis mic...
EKC22642     233 VTLTdk-sYLDLFPk---rDLVYLSPDAEQYYHPA----EGIPVIAGLIHKTt--KDKLALHKAYkeKIKVRRLPIDLID 302 Pacific oyster
XP_003742689 204 YELSpk-pVTELFPr---eNIVYLSPEGEGVLDNLd--eDVIYVIGALVDKTn--LPGVSARRARelGVRSMRFPTSACL 275 western predato...
XP_015790579 296 QMIEq--nFMDLFPk---dDIIYLSPYAPNALKKYd--pEKVYVLGGLPDVMstlDRTGSFPKCKslGIKAYRLPLDYYF 368 two-spotted spi...
XP_015790590 298 SLSFheetFTELYKd---qKLIYLTPHSDKDLCEFd--nDAIYIIGGLSIRS---TAPHSFKKASslKIPNYRFPLSFLP 369 two-spotted spi...
Feature 1                 ## #  #                         
Q7L0Y3       343 qwe--ignKNLTLDQMIRILLCLKnn-gNWQEALQFVPKRK 380 human
EEC20112     348 ewek-dkaKALHLTDVMKILLALKqt-nNWDHALKFIHPKL 386 black-legged tick
XP_015786882 363 smi---gnKILTLDQVLCILVRLKeg-vPMKEALEESVPIR 399 two-spotted spider mite
XP_002125461 391 kwggigarKNLCLTDVFNILVTLRdtdnDWVKAFSALSNRF 431 vase tunicate
XP_013411013 349 lrs--gqtSILPLNKVLKYLVELRdt-gNAYEALKRSVPRR 386 Lingula anatina
CDS25339     217 dwr--sgnKTLTLVAIHSILATAKatngDWKTALEQNIPSR 255 Hymenolepis microstoma
EKC22642     303 kl----tvPRLPINHIIQYVAALRft-rDLEIARKALPKRI 338 Pacific oyster
XP_003742689 276 rweekgdeRPLHLTHCVQILSKLSsg-cPWEEAIRGLDDFL 315 western predatory mite
XP_015790579 369 vfk---ksKKLSLRECVTILDHLKdn-qDIGAALNHGVDSC 405 two-spotted spider mite
XP_015790590 370 fram-rgaKSLEIRECVSILLHFKef-gDIKEAVSQGIDVH 408 two-spotted spider mite

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