5J6P,6H0F


Conserved Protein Domain Family
Yippee-Mis18

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pfam03226: Yippee-Mis18 
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Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus. This entry also includes the CULT domain proteins such as Cereblon.
Statistics
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PSSM-Id: 427204
Aligned: 44 rows
Threshold Bit Score: 61.1794
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J6P_C         5 SVFQCKKCF-QIVGDSNAWVI------SHREy---------------------------LSFTLSDAVENSVRVEDTFKR 50  Schizosaccharom...
EDO02993     113 STIRCLTCS-THLSYASQVVSkgftgrHGRAylvapppsvpvpvippfpptahdrsknlANIRVGRPVNRELLTGHHVVA 191
6H0F_B       303 TSLCCKQCQeTEITTKNEIFSlslcgpMAAYvnph--------------------gyvhETLTVYKACNLNLI--GRPST 360 human
EDN07093      98 SYLRCARCS-ADLCLTSQIISkgftgrHGRAylvaanpstdgts---iaptplmqrsslPNTVTQQPITRQLVTGTHTVS 173
EAW13784      45 SCLHCSRCA-ADLCLTSQIISkgftgrHGRAylvsgelvarav----sltessspnvslPNTVLRRPVARQLVTGLHSIS 119
XP_001400614  47 SCIRCSCCA-ADICLTSQIISkgftgrYGRAylvsgepsla---------rkasptdtlLNTVIQQPVPRRLVTGAHTVG 116
Q2UMI8        81 SYIQCSRCA-TDLCLTSQIISkgftgrHGRAylvsaepiaca------isttcsptetlPNTIMQKPVSRQLVTGAHTVG 153 Aspergillus oryzae
EHY52476      13 KIFGCKNCK-THLADFDDIISrnfrgqHGKAflf----------------------asvVNIKQAEAMERNMTTGRHVVR 69 
O44440        14 SLYGCVVCN-TYLTCSKELTSkaftgsTGPAtlf----------------------kraWNVVYGRCEHRKMTTGWHTVR 70  Caenorhabditis ...
EFC38446     190 LVFSCKHCR-TIFIDSNALFF------NGEE----------------------------HGIITFLKV-HKVEVRENVQI 233
5J6P_C        51 Sddglc----vyseLSCTrCNEVIGKVYNSTPIY-LDDIRDMYTFSMDKLQAYQLGN 102 Schizosaccharomyces pombe 972h-
EDO02993     192 D-------------VNCMiCNTLLGWKYVDARELgQKYKIGKFILETKRCGIFNTYE 235
6H0F_B       361 Ehswfpg--yawtvAQCKiCASHIGWKFTATKKD-MSPQK-FWGLTRSALLPTIPDT 413 human
EDN07093     174 D-------------ITCRfCGSLLGWKYVAAEEElQKYKVGKFILETKRITVFSSWE 217
EAW13784     120 D-------------ICCAfCDSVLGWKYVSAEEEsQRYKVGKFILETRQITKSSTWE 163
XP_001400614 117 D-------------INCSvCGNVLGWKYIAAEEEsQRYKIGKFILETERVMISSFWE 160
Q2UMI8       154 D-------------ISCAfCGNILGWKYVAAEEEaQRYKVGKFILETKRTMTSSLWE 197 Aspergillus oryzae
EHY52476      70 D-------------IKCKqCDETVGWKYDKAYEAsEKYKEGKYILESELLCTVT--- 110
O44440        71 D-------------VFCVtCNQKLGWMYEMAVSEsQTYKETQVIIENANFEKIAGAI 114 Caenorhabditis elegans
EFC38446     234 ApndrfdagsnyypLFCKqCQTLVGRKYLMSDKSpIVDIIGYYTLDIDALSLYEMWT 290
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