Conserved Protein Domain Family
LAX

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pfam15681: LAX 
Lymphocyte activation family X
LAX is a family of proteins is found in chordates. LAX is membrane-associates and expressed in B cells, T cells, and other lymphoid-specific cell types. It down-regulates antigen-receptor signalling in T cells by inhibiting TCR-mediated p38 MAPK activation.
Statistics
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PSSM-Id: 464799
Aligned: 16 rows
Threshold Bit Score: 534.353
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002918256  31 DREN---------------------------------------------------DQSNAIFSGFAGFLAILLTTVIFYS 59 
ELK03342      29 DRDDplpphssvypafpylapipnprartpkesifsnlptshgwglalsfphrstDQSIGIFSGLAGLLALLLVIAVVCV 108
XP_012405691  14 SGFK---------------------------------------------------DQPRVLFSVVAGLLAIFFVIAFLFI 42 
EGW02245      29 EGKK---------------------------------------------------GQNSSIFPGFVALPTIFLVIVAACI 57 
Q5FVQ5        28 EGEK---------------------------------------------------GH--LLFPGFVVLVTIFLVVIVTCI 54  Norway rat
Q8BHB3        28 QGEK---------------------------------------------------GQ--IIFPGFVVLLTIILVIIAACI 54  house mouse
EHB10525      28 EENK---------------------------------------------------DQSSSIFSVFSGLLAILLIITAFCI 56 
XP_013013275  28 EEGK---------------------------------------------------DQSSGILSGFAGLLALLLIITAFCI 56 
XP_017203331  22 EGGQ---------------------------------------------------DQSSGIIFGFAALLALLLVITASCI 50 
ELW47711      29 EGAK---------------------------------------------------DHSISLFSGFAGLLAILLSLVGCCI 57 
XP_002918256  60 LWSWNKWKKqRQVPYFRVTVLPLLSLSRPRQGAKNIYDSLPQRQEVLGRRQWGSNHIFSTESLLSRNSDSLPSEPVPSQA 139
ELK03342     109 LRNWNKRKK-RQGPYLRVTVMPLPTLPRLRQQAKNIYDSLPQRQEEQGRHQSRSVRIFSTESLFSRNSDSPPSAHMPSQA 187
XP_012405691  43 LWFWNKRKK-QQVSYFRVTVVPLVTLSQSRERGKNIYGFLPQSQARPGRRHSRNIRIFSTESLIPRNSDNPHSEHVFSPP 121
EGW02245      58 LWNWNKRKK-RRVPYFQVA--PSLTLPPPRQRAKNIYDFLPQQQAELGRHQSNG---FSTENLLSRDSDS--PEHEATPA 129
Q5FVQ5        55 LWSRKKQKK-RRVPYLQVT--PSLALPPPRQRAKNIYDFLPRQQTELGRHQLSG---FSTESLLSRASDSPEPE--VPQA 126 Norway rat
Q8BHB3        55 LWSWKKQKK-RPVPYFQVA--PSLTLPPPRHRAKNIYDFLPRQQTELGRHQLSG---FSTESLLSRASDSPEPE--APQA 126 house mouse
EHB10525      57 LWNWNRRKK-RQVPYLRVTAIPSLTLPQPRQRAKNIYDLLPRRQEELGRHQSRSIRIFSAESLISRTSDI--PEHVPSQA 133
XP_013013275  57 LWNWNKRKK-RQVPYLRVTGMPSLTLPQPRQRAKNIYDFLPRRQEELGRHPSRGIRIFSAESLISRTSDS--PEHVSSQA 133
XP_017203331  51 LCTWNKRKK-RRVPYLRVTGMPSLTLPRPGQRAKNIYDLLPPRQEDLGRCQSRSIRVFSTESLLSRNPDP--PGHVPSQG 127
ELW47711      58 LWNWNKRKK-RRVPYFRVTDMPWLTLPRPRQRAKNIYDLLPRQQEELGRHPSRSLRVFSTESLLSRSSDS--PEHAPSQA 134
XP_002918256 140 GNALWLHRDHTPANGYAVGIYDNAAGLQICGDLAPSANYVNVRAARDCLSISSEDSRDYINVPTAE----------EIAK 209
ELK03342     188 DNALQVHRAHSHAVSCARDIYDNAMEAQMYGNPIPSAHYINVRAAGDSLSISSEDSRDYVNVPIAE----------EVTE 257
XP_012405691 122 VHVLQSCRTSAPAIGYEVGIYDNTAISQVCGHLVPEVDYINVGASIERMSTSSEDSQDYVNVPNAK----------EASG 191
EGW02245     130 DGPLQIHRASVHAVEYTVGIYDNGTVPQMCGHLASSD--ISVRTSRNNSSISSEESNDYVNIPTAE----------ETSE 197
Q5FVQ5       127 SGSLQKHRASVHAVEYTVGVYDNGTVAQMCGPLASSAHRVCDGTSRNN-SISSKESNDYVNIPTAE----------DTSE 195 Norway rat
Q8BHB3       127 NGSLQMHRVSVHTVEYSVNIYDNGTVPQMCRHLASSTHHVCVRTSRSNPSISSKESNDYVNIPTVE----------DTCE 196 house mouse
EHB10525     134 DDTLQRHQAQVHAVDYSVGVYDNATVPRVSGNLAASAHYINVPASQDGSSISSEETNDYVNVPTAE----------ETAE 203
XP_013013275 134 ENILQRHRVYIHTAGYAVGVYDNATVPQTCGNLPPSACYINVTASRDGSSVSSEELNDYVNVPTEE----------ETAE 203
XP_017203331 128 SSTLQGHGARIPTVGFAVGIYDNAPVPHVCQTLVPSAHYGNDGAPRQRTSSASEDANDYVNVPAADaaaeppasacSTAE 207
ELW47711     135 GSALQVHRAYLHTVGYTVGVYDNASVPQMYGDVTSSAPYVNIRAPEDCLSISSEDSNDYVNVPREN----------EIAE 204
XP_002918256 210 ALASTNSTPANLFALPSAQELELTEEKDKGCGNASEHTSFWSPKSESDDPLSDEEDSSETSNDYVNMAGLTLETLQRKQP 289
ELK03342     258 TLASTNTLPRNLLVFPSAQELESTEEKNEGCGDAHNSTSFWSPETESNDSLSDEEGSSQTSNDYVNMAGLDLRAIQGEHP 337
XP_012405691 192 NSGAMKSLSGNLQDPQTSEESVPRAERDGCSRDAEDSTSIWVLGLEDSDYNGDAECSSHSSNDYVNIPAEDNEEDQGRPQ 271
EGW02245     198 TLTSTKSTPENHCGLPSAQKLELAEGGRAGCGAATNHTGLWTPGRERGASLSDGEESSQTSNDYVNMTGLDLDDIQENQP 277
Q5FVQ5       196 TLTCTKSTPESHLGLPSGQRLEFAEGGHAGCGKATDRTGVWAPGLQGSNSLSEGDDSSQSSNDYVNMTGLDLEDIQESRP 275 Norway rat
Q8BHB3       197 TLTRIESTPENHLGLPSALRLEFAEGGHAGCGNATDHDGFWAPGPKCSDSLSDGDDLSQTSNDYVNMTGLDLENIQENRP 276 house mouse
EHB10525     204 MLTSTNSPPKNVFVLPSAQELECNEEGHKSCGNTSDGTSFGFPRPEGSDPLSDGEGSSQSSHDYVNMTGLDLGDIQEKEP 283
XP_013013275 204 MLTSTSSPAENVFVLPHVQELEFNEEGHESCGNTNDGTSVGSPETEVNDPVSDGEGSSQTSHDYVNMTGLDLGDVQEKEP 283
XP_017203331 208 PPASSCSAPGCCFAHQSAQGLGFTEESHEDCDGAGDYSTLWCP----ADPLSEADSSSQASDDYVNMARLELSGSQETQL 283
ELW47711     205 TLISVSGSPRNV-VLPTAQELEFTEESHEGWDDAGDWPSAWSPPAKGSDPLSDGDSSSQTSHDYVNLAGLDLEVIQEQGP 283
XP_002918256 290 WMALQCYREYENVP-SVPTNGNQQQVEEEVTSSNTDQ-EEGRMEDPGTHIQFVmqSGRFLALGEHVTCQPSAQSETSPIK 367
ELK03342     338 WMSCQCCRDYADVP-PADLNRSQQQAEE-VTSSNTDH-VERRADGLGTHVQLAmqSGKFLDLGDYVTYQPPAQNENSQM- 413
XP_012405691 272 WMNFQSYRAYDNVL-WKQNNWKKPHAGERLTT-NIGG-MLRWTLSLPFDVQCEesRENSLDFWDYENIEPLAQDGNSQE- 347
EGW02245     278 GEAFQGCRDYENVPaAADTNGGQLQTREEVTSSHTDH-GEP--------------VWGALSSVYYMAFQPSPQSEDSEVA 342
Q5FVQ5       276 RVAFQCCRDYENVP-PVVANGSQLQTVEEVTSSTTDR-GEP--------------AQRTLPSVYHMAFRPSAWSEDGAMI 339 Norway rat
Q8BHB3       277 RGAFQCCRDYENVP-WVDTNESQLPTLEEVASSTVDH-REP--------------VWRTLSSVYHMAFQPSAQSEDSAMV 340 house mouse
EHB10525     284 WVAFQCCRDYVNVP-AEDTNGSQQPEEEE-TSSNTDY-GEDRTDGPGIHIQPV--TRRSLSSRYFVAFQLSLQSENSQMT 358
XP_013013275 284 QVDFQSYRDYVNVP-AAAPNGSTQQVEEEEMSSTTDC-GEGGTDGPETRIQPV--TRRSLSSGCYVALWPCIQSGNSQMT 359
XP_017203331 284 WAALQRCGDDGNVA-PAQPDGSQQRAGGEATSSSLDGaAAGRAQGPGTHLQPV--SRRLLASGEVVAFQPPAESESCQL- 359
ELW47711     284 RTDCRCGGDYVNVP-PEEPNRSQQQAEEELTSSNTNC-VAARTESVETHVQPV--TRRFLPPGDYVAFQPFSQSEDSQMK 359
XP_002918256 368 HGEEMSNDTSSDYENV 383
ELK03342     414 -----TKEDSNDYENM 424
XP_012405691 348 TSGETDSEGSDDYINV 363
EGW02245     343 HEEEQSDEDSNDYENV 358
Q5FVQ5       340 PGEEASNGDSSDYENV 355 Norway rat
Q8BHB3       341 HREEQSSEDSSDYETV 356 house mouse
EHB10525     359 HGEEMSEEDSDDYENV 374
XP_013013275 360 HGEEMSDEDSDDYENV 375
XP_017203331 360 QRERTCSEDSSDYENV 375
ELW47711     360 HEEEVSSEDSHDYENV 375
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