2ZY9


Conserved Protein Domain Family
MgtE

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pfam01769: MgtE 
Divalent cation transporter
This region is the integral membrane part of the eubacterial MgtE family of magnesium transporters. Related regions are found also in archaebacterial and eukaryotic proteins. All the archaebacterial and eukaryotic examples have two copies of the region. This suggests that the eubacterial examples may act as dimers. Members of this family probably transport Mg2+ or other divalent cations into the cell. The alignment contains two highly conserved aspartates that may be involved in cation binding (Bateman A unpubl.)
Statistics
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PSSM-Id: 460317
Aligned: 882 rows
Threshold Bit Score: 34.3383
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2ZY9_A       343 VPVLLGTGGNTGNQSATLIIRALAT----RD-L------DLR------DW-R------RVFL--K--EMGVGLL--LGLT 392 Thermus thermop...
EPR79516      56 ETCILTFKGNIELIFSMNLSSMLQI----LSs------fSEY---------S------QYAI--E--NGCLVIF--QSTV 104
ELQ75405      64 ATCILSFKGNIELIFAMHLSSISNV----YNp------vIEY---------A------RFAI--D--NSCMVVV--QSIM 112
EJW02737      51 SNCMLTFKGNAELIFAMHLSSFSQI----KN-L------NSM------HY-I------RYAFdnSclVLAQSIV--IGLS 104
XP_002996819  55 SNCILNFKGNVE-LLYALYLSSLRQ----NDcV------TYE------KY-L------RYVFdnGnlVLLQSIT--IGIT 108
XP_005471122 346 APVINGVGGNLVSIQSSRISTHLHLkhspGE-L------PVGrqscsnPW-H------TFFG--SgaNHRSAKI----LL 405
XP_015789461 343 QPIINGFGGNLVAIQSSRVATYLHKhahkRElV------NET------DS-CchsplfFFFGdgQ--HGRLAFL--MVLL 405
XP_001993977 292 SPVINGSAGNLISVQANNMSSLLHQ----RT-PlgklpkGTRif---eMP-Q------HALC--Y--GTIYSRV--SRLV 350 Drosophila grim...
EDW76546     287 SPIINGICGNLVCVQASNMGSIMHH----RS-ElgtfpeGSRic---eSP-W------RVLL--V--GTIYSRV--ARIL 345 Drosophila will...
XP_001955079 280 SPIINGIGGNMVSVQSSNMGSILHQrselGQ-Vp-----EDTri---lEWpHrvyylgTIYS--RvsRILIAISvpGNVI 348
2ZY9_A       393 LSFLLVGK--VYwdg-----------hplLLP--VVGVSLV--LIVFFANLVGAML---PFLL----------RRLGVDP 442 Thermus thermop...
EPR79516     105 IGISIG-Li-GAsgciliygisllyslrvIIG--CVITCLM---STVFVLLILVIS---LYLS----------HIFHVNS 164
ELQ75405     113 IGLSVG-Vv-GMsvvilrfddafryavitLCS--CLVSCLV---STLVVLLILLAA---VLLF----------KNLQINP 172
EJW02737     105 VGILGFARnvILnvyd----------iqfLSH--IAFICLF--SAFLSSLAIITMLipsVLIA----------VRIGANP 160
XP_002996819 109 IGIIGIARs-IL-----------------VGI---FELKLL--TTILTTSLVTCTIttlIFILllyltiefskW-MSISP 164
XP_005471122 406 LLVIPGQLi-FLhaihlikg--ghtlpspLFTiaFLFASLI--QVLILLCMADCLV----HCL----------WRRGKDP 466
XP_015789461 406 AGPIQLPLv-LIstllsats--qitfaqlLTY--YVCATIQ----VIIILYIGYCF---VNLL----------WLLGANP 463
XP_001993977 351 IAISIPGSlmQAyladymy---sldstvyFVF--VIAFTVAslLQLIILLLSAHVL---VHAL----------WIFKIDP 412 Drosophila grim...
EDW76546     346 ICISIPANalLVyvadyfy---ksyisvnVIF--VASFVLTslLQLLILLWTAHVL---IHLL----------WRWKIDP 407 Drosophila will...
XP_001955079 349 LVYVADYL--YMsyis----------vrwPFLvgFVITSLF--LLLILLWIAHALV---HLLW----------WR-KIDP 400
2ZY9_A       443 ALVSNPLVATLSDVTGLLIYLSV 465 Thermus thermophilus HB8
EPR79516     165 DNFILPLIAVFSDYLSTILLVYF 187
ELQ75405     173 DNVVLPSIAAFSDYFTVLSLIFF 195
EJW02737     161 DNIVLPVISSFGDFLDILILIYS 183
XP_002996819 165 DNVILPTLGSLSDFLSIRFLILF 187
XP_005471122 467 DSYSIPYLTALGDLLGTALLSIA 489
XP_015789461 464 DDNAIPILTALADLLGTIVLVSG 486
XP_001993977 413 DSAAIPYLTAFGDSLGTGLLAIT 435 Drosophila grimshawi
EDW76546     408 DSSAIPYLTALGDCVGTS-FLSI 429 Drosophila willistoni
XP_001955079 401 DTAAIPYLTALGDALGTG-LLAI 422
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