Conserved Protein Domain Family
IFT57

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pfam10498: IFT57 
Intra-flagellar transport protein 57
Eukaryotic cilia and flagella are specialized organelles found at the periphery of cells of diverse organizms. Intra-flagellar transport (IFT) is required for the assembly and maintenance of eukaryotic cilia and flagella, and consists of the bidirectional movement of large protein particles between the base and the distal tip of the organelle. IFT particles contain multiple copies of two distinct protein complexes, A and B, which contain at least 6 and 11 protein subunits. IFT57 is part of complex B but is not, however, required for the core subunits to stay associated. This protein is known as Huntington-interacting protein-1 in humans.
Statistics
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PSSM-Id: 463118
Aligned: 45 rows
Threshold Bit Score: 266.048
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001020901 293 NEDIYEKLTLLEYH--NFFCKPMH--RDPVSKVFFSIsdqTPAQNNKKFFYFAELCYWIMSIQKyDKknkIQA---AL-K 364
Q4DZS7        27 MEDLIDKLRILRYE--KDFCPRVKppFKPLSKYYFSGp-sSIDNPNAQFHYFTSLCSWLMGLAG-HN---FEP---PG-Q 95  Trypanosoma cruzi
A0E8V3       291 MEDIYEKLSLVQYH--QNFCVPLK--KKPISKYFFSLd--eSVNSSYRFYYFVDLCYWLMNLPKqKKnklAQPikyS--- 361 Paramecium tetr...
A0E968       291 MEDIYEKLSLVQYH--EYFCIPLK--KKPVSKYYFSLd--eNVNQNQRFYYFVELCYWLMSLPKqKKnkmAQPiklNY-- 362 Paramecium tetr...
EGR31851     293 NEDIYEKLTLLEYQ--KYFCKPIN--RKPISKIYFALpdnNMILNNEKFFYFAELSYWIMSIKKyDQknkILA---AQ-Q 364
A0C6M8        17 MDELYDKLILLNYE--QSYLKQKG--GKPLNRAYFV----NQTNSSEQFNQFKTLVKWLFQQNDvQT---SDF----N-K 80  Paramecium tetr...
XP_001313886  15 MRQIYDNLQYLNYE--TDFDPIKRk-LPYLTPIYFAV---QQKSPKEQFDYFAGLCVWMMQTFNgSQ---IET---PS-D 81 
ESS30354      36 SERIYNLVSLVNSCd-EKLLDCRD--LKRLTRYSFCLh---EEPAWPQLQLYQSWVVHILRLLG---------------K 94 
EFC50338      49 MEKIIDKLKLLNYErrKDLFPSHA--YGGLPRYYFAh--hDKDHPHEQFHTFIAVTTWLISDVLkLDd--YER---PDfQ 119
KAE9026673    25 MGNVLEKLRVLQYE--REFGKKKS--FAPFSETQFAVla-aGTNASAQFKGFLDLVTFLLKSCG-QE---FVV----D-K 90  Phytophthora fr...
XP_001020901 365 LkslgnwESVDECAQQLLFDLKKWGLRLpDsLNVQHIRNGYGDTVCFILNDILNRELIRLNFKFEDPKHTDVQNg----- 439
Q4DZS7        96 F------DDPNATSTNILGELRAMNISApN-LAPNRIRQGSGEAVLTILSVLSDHALLKKGFTVRSVDYTNVEK------ 162 Trypanosoma cruzi
A0E8V3       362 -------NNLEDTARKLLQDIKAWGIKLpEqLGSPHISSGFGDMVCFILNDLLNRELIRVNFKFELPQFGGDLSnsqvps 434 Paramecium tetr...
A0E968       363 -------HNVEETARKLLIDIKAWGIKLpEqLGSPHISQGCGDMVCFILNDLLNRELIRINFKFESPNFGKDLEssvi-- 433 Paramecium tetr...
EGR31851     365 LkdngiwDSIEECGQQLLQDLRKWGSRLpDqLNISHIRNGYGDTICFILNDILNRELIRVNFKFDQPIFKNEQC------ 438
A0C6M8        81 L------DDPVTLSQNIINELKNIGIEV-D-FPPIKLKQGFGEYVVYVLLQLATKALQKKKFQYKKAKIEQQSQt----- 147 Paramecium tetr...
XP_001313886  82 Y------DQPATVTDNIFNNLNGLGIKV-S-FQPAKLISGHGSHCCLILDALCRMSLKKKGFS----------------- 136
ESS30354      95 EieirkdDDPVAVTEAIVDSLQGFHFGGiE-VSVSSLRKGWGYIPCKVLHELLKELVTGR--ALQLPTYDPCNRkcgat- 170
EFC50338     120 L------DDPNTTTQNLAFYLKKMGIPM-D-FPPTKLRQAWGEPVCYVIDQLLNRALKESKVKLKAPEIPEEIK------ 185
KAE9026673    91 Y------DDPNTSVNKLILTLKTLGFPL-D-FPASKLKLGYGEAVCAALDFICDQALAARRFDWPRPQYP-KED------ 155 Phytophthora fr...
XP_001020901 440 ----QQETENGvLQDpdlnEYMIEEEDIQDEDSIvg----------------eEEQGDLl---nGQYNKRQNGEEaydyk 496
Q4DZS7       163 ----YDELDGVtDAD----DDNGIGEEVEDNVMI-------------------ESDDEE-----ELYVRATGERL----- 205 Trypanosoma cruzi
A0E8V3       435 hhiqYDEQDFPeELTeedqD-EVENDEFTQSILFyqk-------------kfkTEQPDFn-------------------- 480 Paramecium tetr...
A0E968       434 qvnkIDNEDLVeIQEeeneNEEVEQDELTQSILFyhk-------------kynNESTDYn-------------------- 480 Paramecium tetr...
EGR31851     439 -------------------DQKVILLDSENEESIkein-----------------------sinSSYYEEEKHEEfinkd 476
A0C6M8       148 ----rQDDEPVqETGsvssDSDPDVASEEEPEDVfte-------------qgfQKDEDK--------------------- 189 Paramecium tetr...
XP_001313886 137 ----PSSFRVVsGLGgkddEVEVRGEDDEDDIVDdvv-------------dvqEDEDKEndaiiT--------------- 184
ESS30354     171 ---------------hsveSIEDFAESHEADLGAhsg-------------ffsSDSEDG--------------------- 201
EFC50338     186 ----FRDDDEIpEES----------EDIEDNEDMqhd-------------ndsENEDEM---------YYTVGSKndtgs 229
KAE9026673   156 ----FADEAEV--DD----DAEVDTANDNDENALpgaeeeaeelysdlvrsgkAAEDQHd-------------------- 205 Phytophthora fr...
XP_001020901 497 kIIDEDREMIISNVDPLEWQKECLR--------VTTELQNfdlkikknEitAQINenDYINNLNRLQKFQRgmNMQAQIL 568
Q4DZS7       206 -VKEDAGVPLESEINAEEWNLEVER--------VGPLLQV--------R--SDALq-DWRSRIESAGVLLR--AVEKMYP 263 Trypanosoma cruzi
A0E8V3       481 -QIPQNRQIIQTKIALNEWTNEYNR--------VEKELNKfeinlkenK--SYLN--DYQRSMNLVKKCSKqlTIASQYF 547 Paramecium tetr...
A0E968       481 -QVPQDRQVIETKVAMNEWTKEFNR--------VEKEFSKfeanlkvnK--QYLK--DYERTIITISKCSKqlSILSEHL 547 Paramecium tetr...
EGR31851     477 iEKNENNIIIKSEINEQDWKKEYKR--------VYQELHDfdkninkfE---RQKqeEYYFNLYKMQKYKK--SLKNDIF 543
A0C6M8       190 -------MVIESNVNPKEWAKEVER--------AAQKIKIv------iK--PDAG--EWRQHFDATKQYSN--SIKTILP 242 Paramecium tetr...
XP_001313886 185 ---DYGNDPQSKVIDSLELKAEAER--------VAPRLQIr------iP--AEKS--DWRTHFSQMNTHQK--TITDIMT 241
ESS30354     202 -------------------EIEARRaedlnepeAAPAASAlnkmsrtfA--QD----QWKGEVEQTLEFKK--TFDEQLP 254
EFC50338     230 kDQEKHLEMIEGYHNAQEWRLETER--------LSSQLVVr------lN--VDHK--DWRTHVESMEEQNV--SIRDLTP 289
KAE9026673   206 -LDQSFQQMIMSEVDPLLWKTELER--------VGPRLKLkgg--agaA--AAGK--EWHAHIERSREHET--VMRELLP 268 Phytophthora fr...
XP_001020901 569 Q-EPFVNKIITNWQNQLDQIEKGEQRI--NQGNIDSINV-LKEKVQSKKKFLLDLEQKSEQVKSQIQNFDSMNEQYEKVK 644
Q4DZS7       264 EvKQMLQHVADDLEKSRDRIQKREQTL--AQQFSDQVED-YRVKLRELNTSQDSANMASQSVEQLSAELNQLSGLLDQVK 340 Trypanosoma cruzi
A0E8V3       548 K-SNEVQDIQQQWINYLEIIPKLETQI--TNLIQPELREiLYNNRQTISQFEIKINTLSKSNSSKLE----LDQQLHQNI 620 Paramecium tetr...
A0E968       548 K-SSEVQEIQQQWINYLELLPKLETNV--TQQIPENVQItLKENRNTISNLQFQISQLNKGNSEKQE----IDQQLNQQL 620 Paramecium tetr...
EGR31851     544 EyKSIHDKFYVQLQNQLDDIKNGQYII--NSGNLENIQI-LQEQARNKNEFLKELKQRSEQVELYVKHLNNLKEQNTRIK 620
A0C6M8       243 EaRIKLERISDELGEILDRITKREYNI--NENMSEMCLE-FKKKNEEYKKIELQYQNYTNAKKEMTDQYKQIQEKFETVQ 319 Paramecium tetr...
XP_001313886 242 QlSPILTKVGADVTQAIDAIENREKML--NNRFQTSVVD-YAERAKQLETVEKKYHERVTTVNNLKTALNDVIDKLNNTK 318
ESS30354     255 SlCHAFKQLHEELQEMLTKVETREKWI--EQKFSHIISD-HGEVHQELVNQTKRRQKLVVQLEDLQTKQAVTQEACDRSS 331
EFC50338     290 SsTSQLEKIAEDIEKINSRIQKREKMLsdDSSIGNLLAN-YSKNQQELDEITKKYKELEETISVLSGDLGKINQDLSDIK 368
KAE9026673   269 RaNAQLRLLGTQLTEAVGRMGAKEKTL--NNQYEHLRQE-YTALKEKLQAATEVSKAGADRVNVMTTEYAETTEQLKETK 345 Phytophthora fr...
XP_001020901 645 KEIVEREKLITGNDQTNKIKDAIQKIKTEIKSMTIKIGVLQSNL 688
Q4DZS7       341 RGIEDREAKISDTTPLMQVKDAVTKVRAEIKQMSLRIGVLQHAV 384 Trypanosoma cruzi
A0E8V3       621 VDIQSRIPTLNDNRP--KQRQIINQLKSDINDLNVKIGILQTQL 662 Paramecium tetraurelia
A0E968       621 LDVKERTPVLADNRS--KQKQLINQLRNDIRDMDIKIGIMQTQI 662 Paramecium tetraurelia
EGR31851     621 KQIQEKEKLITNNNQKQKIQEAIINLNKEIKNMNLKIGIIQASI 664
A0C6M8       320 NKLNEHGSVSTNQSPVISIKASLTKLRLEIKQMDLRIGVLSHTI 363 Paramecium tetraurelia
XP_001313886 319 QNLDEKQKEVSDNSPLMNIKTALAKLKEDIKQLELRSAILQRSL 362
ESS30354     332 KLLQDKCNRATDARPIQELTKTLTTLRKEIKQMELRSGVLQHTS 375
EFC50338     369 VNAEDLTKKMADTTPLREIKEALVKIRNDIKQMDMRAGVLQNQV 412
KAE9026673   346 GVMDERGAKMTDTSPLVHIKDALKTLAAEIKNFELRIGVVSHTL 389 Phytophthora fragariae
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