Conserved Protein Domain Family
DUF5521

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pfam17659: DUF5521 
Family of unknown function (DUF5521)
This is a family of unknown function found in Eukaryota. Family members include the human CXorf57. High-throughput sequencing used to identify genes driving tumorigenesis in Avian leukosis virus (ALV)-induced B-cell lymphomas, showed CXorf57 as the 10th most frequently targeted common integration site by ALV. ALV induces B-cell lymphoma and other neoplasms in chickens by integrating within or near cancer genes and perturbing their expression. CXorf57 encodes a protein that has a conserved putative replication factor A protein 1 domain. Several proteins with this domain have been shown to be involved in recognition of DNA damage for nucleotide excision repair. CXorf57 contains 24 unique integration sites that are spaced throughout the gene and in no preferred orientation.
Statistics
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PSSM-Id: 465441
Aligned: 7 rows
Threshold Bit Score: 1710.07
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015325827   2 SGESGQPQADPSQAGVDMPHPERNGAAVPRGVVRRVGALGRRSWIQKVFEQVIDSPRRWVTPLEVVPVAVLAVQRYLLED 81 
XP_006082405   2 PGELDQPQAGASHAGMVRQDSEVNGPWVPGGVRPKAGALGPRSWIQTVLEQVRDSPLQWVTPSEVAPVAVLAVQRYLLED 81 
XP_002720218   2 SDESEQPQEGPSGAGLDWSNLERNRAGVPGGVIRRARGQGCMSWIQKVLEQIIDSPLKWVTPKEVAFVSVLAVQRYLLEE 81 
B2GV47         2 SGESDQPQPGPSHAGLYLEHRERDQAGVPGGVIRRAGSQRHRSWIQTVIEQITGSPRQCVTLSEVVPVSVLAVQRYLLED 81  Norway rat
XP_003918135   2 SGESGQPEAGPSHAGLDWPNPERNRAGVPGGVIRRAGAQGPRSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLED 81 
1_pfamImport   1 SGESVQPQAGPSHAGFDFPYPEPIRAAIVPGGVIRRAAPAPKSWIQKVLDQIIGSPRQWVTPSEVVPVTVLAVQRYLLED 80 
XP_003414918   2 SGKSGQPEAGPSHAGQDQRRRERDRAGVSGGVIRRAGAQGPRSWIQKVFEQIIDTPRQWVSLSEVVPVAVLAVQRYLLED 81  African savanna...
XP_015325827  82 EPRNVKPKPPLYCFDVTISDGVYQEKCYLDPSLNSLVYKNILKVGIEVRIFRVSCIYNEKRIGQGILCIDNVLC-GELLE 160
XP_006082405  82 EPGDILPKPSRYGYDVTISDGVYQEKCCLHPRLNFLVSKNILRPGIKMRIFRVSCLYNEKRLGQGILCIDNIDCkEETLD 161
XP_002720218  82 EPNDTVRGGPLYCYDVTISDGVYQEKCYLDPSLNSLVYKNILKVGIEMKISRVSCLYNEKRLGQGILCIDNVQC-GRTLD 160
B2GV47        82 EPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNFLVYQNILKVGIEMRISRVSCLYNEKRLGQGILCIDKVHC-GEPLD 160 Norway rat
XP_003918135  82 EPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNEKRIGQGILCIDNVHC-GETSD 160
1_pfamImport  81 EPRDIIPNLPLYCYDVTISDGVYQEKCYLDPSLNFLIYQNILKVGIEMRISRVSCVYNEKRLGQGILCIDNVHC-GETLD 159
XP_003414918  82 EPRDMLPKLPLYCYDVTISDGVYQEKCYLDPRLNSLVYKNILKVGKEVRITRVSCVYNEKRIGQGTLCINKVHC-GETLK 160 African savanna...
XP_015325827 161 SVSLETPFRNSAHREVPERPLRGEKSHYLPLWNNEDPYGDIWLNNKQPKEHEFNHTKIISLSHLEMTWSNTKNLPPLLVR 240
XP_006082405 162 TISLATPFRNSAHQEIPERPLRGGKSHYLALWNNEDPYGDIWLTNKQPEEYNFNNTKIISLAHLEMSWTKRTNYPALLVR 241
XP_002720218 161 AISLETPFRNRAHGVKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPKEHNFTNTKIISLSHLETTWTDRNDFPALLVR 240
B2GV47       161 VISVETPFRNRAHEEKPERPLRGSKSHYLALWNNEDPYGDIWKTNKQPEEFNFNNTKIISLSHLEMTWHNRKNFPALLVR 240 Norway rat
XP_003918135 161 SISLETPFRNRAHQEKPERPLRGGKSHYLALWNNEDPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVR 240
1_pfamImport 160 TVFVEIPFRNRAHGEKPDRPLRGVKSHYLALWNNEDPYGDIWLTNKQPAEYNFSDTKIIALSHLETTWFNRRTFPALLVR 239
XP_003414918 161 AISLETPFRNRAHEQKPERPLRGGKSHYMALWNNEDPYGDIWLTSKRAKEYNLSTIKIISLSHLEMTWSTRKNFPALLVR 240 African savanna...
XP_015325827 241 ILYKSKLRYYGKPNKKIIEPYQTFLEVADSSGTVSMIMWNTLCPEWYKSLHVGLVLLLQNYSIRKSYPFRMQPLPVDPHI 320
XP_006082405 242 IMYKSRLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKCLRVGSVLLLQDYSVKKSFPFRLQPLPVDPQI 321
XP_002720218 241 ILRKSKLRYYGKPDKKTIEPYQTVLEVADRSGTVLVILWNALCPEWYKSLRVGLVLLLQDYSVKKSYQFRMHPLPVDPQI 320
B2GV47       241 ILHKSKLRYYGKPNKKMIEPYQTYLEVADSSGMVSVIMWNALCPEWYKSLRVGLILLLQDYSVKKSYPLRIQPDPVDPQM 320 Norway rat
XP_003918135 241 ILHKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRVGLVLLLQDYSVKKSYPFRIQPVPVDPQI 320
1_pfamImport 240 ILQKSKLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNTLCPEWYKSLHVGLVLLLQDYSVKKSYPFRMPPLPADPQI 319
XP_003414918 241 ILYKSKLRYYGKPDKKITEPYQTFLEVADSSGMVSVIMWNALCPEWYKSLQVGLVLLLRHYTVKKSYPFRMQPPPVDPQM 320 African savanna...
XP_015325827 321 KLISTMEICLNIRDFP-NIIIIPEKQVKPEWRLPKLNHRFVTRSELDKMPNNYICDVIGVLVFVGRVQRSKKKESREDFW 399
XP_006082405 322 KLISTMEVCLNLRDPPtNINIIPEGQVKPEWRLPKLNHRFITRSELDDIPEKQICDVVGVLVFVGRVQRLKKKEYGEDFW 401
XP_002720218 321 KSISTMEIGLNLRDPPtNIIIIPENQVKPEWKLPKLNYRFITRSELDDMPKDSICDVIGLLVFVGRVQRSKKKENREDFW 400
B2GV47       321 KLISTMEICLNLRDPPtNIVIIPEKQLKSEWKLPKLINRFITRSELDDMPENSICDVIGMLSFVGRVQRSKKKENSEDFW 400 Norway rat
XP_003918135 321 KLISTMEICLNLRDPPtNIIIIPEKQVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKKKENREDFW 400
1_pfamImport 320 KVITTMGICSKLPFNRsNVLMLEDKQLHISFKLEKLRCHFFKESELDDMPENRICDVIGLLVFVGRVQRSKKKESREDYW 399
XP_003414918 321 KIISKIEICLNLQDPPaNIKIIPETQVQSEWRLPQLNHRFVTRSELDNLPENHLCDVIGILVFVGRVQRLKKKENSEDFW 400 African savanna...
XP_015325827 400 SYRWIHIADGTSEQPFIVELFSTSQPEIFEHIYPMTYFTCTQLKVVRNDDQVPKLLYLTTTNESHIFMT-CHK-GQLRND 477
XP_006082405 402 SYRWIHIADGTSEQPFIVKLFSTSQPEIFENICPMTYFMCTQLKVVRNNNQVPKLLYLTTTNESQIFII-GHR-GQPYAN 479
XP_002720218 401 SYRWIHIADGSSEQPFIVELFSTSQPEIFENIHPMTHFMCTQLKVVRNDAQVPKLLYLTTTNESRVFIT-DLN-DQPYTN 478
B2GV47       401 SYRWIHITDGTSEQPFIVQLFSTSQPEVFENIYPMTYFVCTQLKVVRNNSQVPKLLYLTTTNESRVLIT-GHR-GQPYTY 478 Norway rat
XP_003918135 401 SYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKVVRNDNQVPKLLYLTTTNESGVFIT-GHR-GQPYTY 478
1_pfamImport 400 SYRWIHIIDGTSELPFIVELFSTSQPEIFENIYPMSYFVCTQLKVVRNDTQTPKLLYLTTTNESRVFMTgGHR-GQPYTY 478
XP_003414918 401 TYRWIHIADGTSEQPFIVELFSTSQPEIFENLYPMTYVLCTQLKVVRNNDQVPKLLYLTTTNESQVFIT--GQkGQPYAY 478 African savanna...
XP_015325827 478 DAKVKNFIQWVKEKNDSGEGKNTVIGGYYPYPPVPETFWKYSSSLKVESLLTAISEVKVEIEDLQYREQKRIAIQGIITV 557
XP_006082405 480 DTKVKSFIHRIKTKTDSGEMKNTVIGGYYPYPPVPETFSKYSTSVKVQSLLTAISEVRKEIENLQYREQKRIAIQGIITI 559
XP_002720218 479 DTKVQNFIQWIATKTESGEVKNTVIGGYYPYPPVPETFSKYSSSVKVHSLLTPVSEVKKEIEVLQYREQKRIAIQGIITV 558
B2GV47       479 DTKAKKIIQWIKT-KTNLEAKNTVIGGYYPYPPVPETFSKYSRFIKAESLLTTISEVRKVIEDLQYREQKRIAIQGIITA 557 Norway rat
XP_003918135 479 DAKVKNFIQWIRTKSDSGEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITA 558
1_pfamImport 479 EAKVKNFIQWIKTKTESGEVKNTVIGGYYPYPPVPETFTKYSSSVKVESLLTAMNEVKKEIEDLQYREQKRIAIQGIITV 558
XP_003414918 479 DVKVKNITQWIKTKTDAGEMKNTVFGGYYPYPPVPETFSKYSSSVKVESLLTAISEVRKEIEDLQYREQKRIAIQGIITV 558 African savanna...
XP_015325827 558 IKYVPYHSATQSASASETLRNAKRPSTSEAARKESQSQEKDGKRHHDDGsgRSQCHSACASSNPVPKKRITQTPSGKQIP 637
XP_006082405 560 IKYVPHSSATGSSSASETVQNVNQPSTSQTAIKESQSQELDGKQHQDDG--SVSCQTTCTSLSPPKKKRILQGPFAKLVP 637
XP_002720218 559 VKYIPHSSAAESASASETYQNADQTSTSKASREESESQGRISTWHQYDRs-MSSQCFQPASLSPSNKRRILQGPYSKPFA 637
B2GV47       558 IKYIPYNHSAKSAPASETLQNASPPSTSQAAAKEGHYHERGSKRSQDDRp----MDSLPMVLSLCAKRKILQGPTANPVP 633 Norway rat
XP_003918135 559 IKYIPHSSATESASASETLRNANRPSTSQAARVEIQESNGKRHQDDEPVn-SQYFQTTSTNLSLSNKIRILQGPHANPVA 637
1_pfamImport 559 VKFIPHSSA-----------------TESATASEIPWINRPSTSHDDEPmsFQSFQNASISLYTSNKVRVLQGPIAKPVI 621
XP_003414918 559 IKYIPDRRATESASTSETLRNANLPTTSQAARGESQSQERDGKRHHHDGd-PVSSQTTSSSLSPSKKKRVLQGPDAKVVA 637 African savanna...
XP_015325827 638 VPQPETSSQTKESKPSMPSSSDSgRENPSHTFVVRAKKTISDKWESQLWRDKKFSLIDHLRYSRVHPESIPRKFSSEHRH 717
XP_006082405 638 IPQPETSAQTRENIPDTPSIFQR-RESASTGIKWKARKTLTHRWESQLWREKKFGLREHLCYRFVYPESIPRKFIFEHKN 716
XP_002720218 638 VPQAEASTQTYGTRIGMLSIFQ-----RQESFGGKTGKILSDRWESQMWRDKKYHLIDHLHYSRVYPESIPRKFLFEHRN 712
B2GV47       634 VPQPHSSAQMKGNKPNIP----S-RENSTANATGKSKRIINDRWESQLWRDKKFSLRDHLHYGHVDPESIPRKFILGHEK 708 Norway rat
XP_003918135 638 VPQPGASVQTKGIKPGMPSIFNR-RANTNASLQGKARKTISDRWESQLWREKKFGLIDHLHYSHVYPESIPRKFMFEHRK 716
1_pfamImport 622 VTPPEAFLQAKGNRLFRPSIFQY-RDGTSSVIQLKARRTLNERWESPLWREKRLGLIEHLHYSNVYPESIPRKFILEHKK 700
XP_003414918 638 VPQPETSSQAKGNKPDMPSTVRR-QESTSTHSLGKARKPISDKWESQLWREKRFRLIDHLHYSHVYPESIPRRFIFEHRE 716 African savanna...
XP_015325827 718 FLGQQFNSQPAKYVPPEGKVPKLDHFKSARSLGHFELTILGLNHEIAIDVAFLPMYSLQDAQTSQVDTLLTCMNYSCVYP 797
XP_006082405 717 FLIQQYICQPAKYIAPEERPLKVSDFKSARSPGHFEVTILGLNHERAIDVAFLPLYCPEDIRTSQIDTLLTCMNYSCVYP 796
XP_002720218 713 FLAQQYNSQPAKYIPPEERPPKLEDFKSARSLGHFEVTILGLNHDIAIDVAFLPMYSPEDVRTSQIDTLLTCMNYSCVYP 792
B2GV47       709 FLTQQFNSQPAKYVPPEGKPPKLDEFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDVETSQIDTFLTCMNYSCVYP 788 Norway rat
XP_003918135 717 FLSEQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVTILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYP 796
1_pfamImport 701 FLIEQYNSQPAKYIPPEGKPPKLDDFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDLRTSQIDTLLTSMNYSCVYP 780
XP_003414918 717 FLTQQYNTQPSKYIPPEEGSPKLEDFKSACSLGHFEVTILGLNHEIAIDVAFLPMYCPEDVQTSQIDTLLTCMNYSCVFP 796 African savanna...
XP_015325827 798 QASTSSEKTTGSRVLAGDIIKAVSKMDREHVICILDICNLGSNKAEVYLHKIY 850
XP_006082405 797 QEVTDSERMPGTTALAGDIIKAVTELDRVHVICILDICNLGDNNVEVYIHKIY 849
XP_002720218 793 QEVTDSDQSPDPKALAGDIIKAVTELDRVHIVGILDICNLGNNKVEIYLQKIY 845
B2GV47       789 PAAPVSGRVPDPKAVAGDIVKAAADLDRVHIIGILDICNLGNNKVEVCLQKIY 841 Norway rat
XP_003918135 797 QDTTGNDRLPGPRAVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIY 849
1_pfamImport 781 QEVANNDRLPGPRAVASDIIKAAAELDKVHIIGILDICNLGNNKMEVCLHKIY 833
XP_003414918 797 PEVTGNDRLLGPRALAGDIIKAVTELNRVHIIGILDICNLGDDKIEVCLQKIY 849 African savanna elephant
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