Conserved Protein Domain Family
PRCC

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pfam10253: PRCC 
Mitotic checkpoint regulator, MAD2B-interacting
This family constitutes the major, conserved, portion of PRCC proteins. In humans this family interacts with MAD2B, the mitotic checkpoint protein. In Schizosaccharomyces pombe this protein is part of the Cwf-complex that is known to be involved in pre-mRNA splicing.
Statistics
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PSSM-Id: 463026
Aligned: 64 rows
Threshold Bit Score: 38.7599
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005245370 275 NFFSLpek-------------------------------aepPGVEPYPYPIPTV---------------PEelppgtep 308
GAC77699     270 DFFSLeak-------------------------------ppaKSSATQFGNSFMIsaapsidqpsepdepaaqtpldeyp 318
ELU43892     202 DFFSLgst--------------------------------saAPSIPTSGTAPSTsssitlmsapevkdfEPpvptlfdp 249
XP_007395936 231 DFFSLgsasssss---------------------ptpvtrsaTPTPSASIPFIPTpslpsvssapkiddfAPpeptpqdp 289
EMD38364     228 DFFSLgsasatpsp--------------------ppraappaSNPLTATSSAPSVpfipslssapkvdefVPpeptpqdp 287
EED79532     263 DFFSLsmyltlsilhfvfdnptgsststissttpakpsaavlTAPSVASSSAPSLplfpgvssapkvddfVPpeptpqdl 342
EPS98565     216 DFFSLgssssssp---------------------sfpistsiTSAPSIEPSAPKLplipgvssapkvedfVPpeptaedp 274
EAU88482     191 DFFGLgnask---------------------------ssapsIPSSSSSTSSSTLpsipsmsaapsvpefKPpeptpydp 243
EFJ00453     211 DFFSLgatsr---------------------------plptaGSSSTASSSSPAAplvpsrsaapeiptfQPpeptptdp 263
XP_003319658 162 NLFGLppt--------------------------------ssSDSSASTKRVPVEtlepqipltvssapqvaaevpppps 209
XP_005245370 309 epafqddaanaplefkmaagssgapwmpkpgddysynqfstygdanaagayyqglqqhlghsplrgimrflnsksgkrtc 388
GAC77699     319 gw-------------------------------------------------------------------------qldtd 325
ELU43892     250 ypgyyqlpsgew-------------------------------------------------------------------- 261
XP_007395936 290 ypgyyllpsgqw-------------------------------------------------------------------- 301
EMD38364     288 ypgyymlpsgaw-------------------------------------------------------------------- 299
EED79532     343 ypgyyllpsgqw-------------------------------------------------------------------- 354
EPS98565     275 ypgyymtsagtw-------------------------------------------------------------------- 286
EAU88482     244 ypgyyqlpsgaw-------------------------------------------------------------------- 255
EFJ00453     264 ypgyyqlpsgkw-------------------------------------------------------------------- 275
XP_003319658 210 lmdpyp---------------------------------------------------------------gywqrkdgswc 226
XP_005245370 389 fvpsfdyysggyypaqdpaLVPPQE--IAPDASFIDD-----EA--------FKRLQGKRnrg------------reEIN 441
GAC77699     326 gswvpvtpeahaqlaayeqslaPPPtaTSKGAANLDG---------------TRDLLAAGltpddirafdasaaardAYS 390
ELU43892     262 ---------amhdpkyykkvieqltsgpDLQTGNKSE----------------------ArefadrskedmatfdpsEEL 310
XP_007395936 302 ---------aaydpayykkfydkwkkeyDAHVRALEK--------------------GVEkgfegietegaaevnafEEM 352
EMD38364     300 ---------aahdpeyyrtfydkwkreyDAHVRALEK--------------------GAAkgfedvetqgahevnaqAEM 350
EED79532     355 ---------aayepeyyrsfynkwkkeyDDHVRALEK--------------------G-IkgfeavetegarefnalQEM 404
EPS98565     287 ---------aaydsgyykkfydkwkkeyDDHVRSLEK--------------------GAGkgfenletegarevnalSEM 337
EAU88482     256 ---------aqhdpeyyatfmkkwqkeyDAHVRALEK--------------------GHVkgfedmeqagiqdvdpvKEM 306
EFJ00453     276 ---------eahdpafyqkfykkwqaeyDAHVRALEK--------------------GQVrgfedmdesqmgevdaaAEM 326
XP_003319658 227 erdpsdplwkafylqhysqPTLETTttTGSSSSSSDKhsklpKDffkdapnsLVQFDAKQvaq------------taWEN 294
XP_005245370 442 ---FVEIKGDDQLSGAQQWMTKSLTEEKTMKsfs-------------kkkGEQPTGQ-QRRKHQITYLIHQAKERELELK 504
GAC77699     391 rggD-DDADADKYAAAAEFAAGNRDAMA----------------------QRKPGMLkGLKKGQLSSLISLADENRSKAE 447
ELU43892     311 rq--gQIAELEKRKAVTTTPSDAPAVPRMKAnyswcsmfdhqtellyfiqVQKSTGL-ARSRHQLSTLLTEAYANREALE 387
XP_007395936 353 ekaKHEIQEREEKKALTKGGQHVQVAPRMNIk------------------GAALSGR-ARSRHQLSTLLTEAYGNREALE 413
EMD38364     351 eraKIEIQEREERKALTKGGADAPVAPKMNIkvefsafat-ctfhlrvlqGAALGGR-ARTRHQLSTLLTEAYQNREALE 428
EED79532     405 ekaKREIQEHEERKALTTGDTEA-AAPKMNIk------------------GAALGGR-AKTRHQLSTLLTEAYQNREALE 464
EPS98565     338 eraKKEIQEREERKALTTGGADVAAAPKMNIk------------------GAALGGR-ARTRHQLSTLLSEAYQNRESLE 398
EAU88482     307 eraKKEIQEREERKALTKGAGAGPSVPRMKIt------------------ASKMSGI-ARARGQLSTLLRDAYENREALE 367
EFJ00453     327 eraKVEVKLREERKALSRGAAAFTEQPKMKIt------------------ASKLSGV-ARSRHQLATMLHEAYNNREALE 387
XP_003319658 295 kpkIIDPREEARQEQQASAATKP---------------------------SKHISSM-ARGRHQLSSLLTDAQANRAELE 346
XP_005245370 505 NTWSENKLSRRQTQAKYGF 523
GAC77699     448 EKWKRGRDARARRANQYGF 466
ELU43892     388 EKIAQGKRNRKEAGSKYGF 406
XP_007395936 414 EKIAQGRKNRKEAGNKYGF 432
EMD38364     429 EQIAQGRRNRKEAGNKYGe 447
EED79532     465 ERIAQGRRNRKEAGNKYGe 483
EPS98565     399 EKIAQGRRNRKEAGNKYG- 416
EAU88482     368 EKIAEGKRNRKEAGNKYGF 386
EFJ00453     388 EKIAEGRRNRKEAGNKYGF 406
XP_003319658 347 DRISRGKFNRKAGGAKYGF 365
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