Conserved Protein Domain Family
EMC6

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pfam07019: EMC6 
EMC6
This family consists of several Rab5-interacting proteins (RIP5 or Rab5ip) including ER membrane protein complex subunit 6 (EMC6) and RCAF1. The ras-related GTPase rab5 is rate-limiting for homotypic early endosome fusion. Rab5ip represents a novel rab5 interacting protein that may function on endocytic vesicles as a receptor for rab5-GDP and participate in the activation of rab5. EMC6 interacts with Rab5A and BECN1/Beclin 1 and regulates autophagosome formation. EMC6 is part of the EMC complex, required for efficient folding of proteins in the ER and for post-translational membrane insertion of tail-anchored (TA) proteins.
Statistics
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PSSM-Id: 462067
Aligned: 161 rows
Threshold Bit Score: 43.6836
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFR02968       30 LHSLIAFLLGTAAGILGLQSAYGFTFYLLGTIFVSFLVH---GLLVKdnttpraagkstnkgvsgvgAYFPGdgelvpvs 106 
A0CBX9         28 LRVYGSLNAGMIAGILGMDGWIGMGIYVVVFLIVSACLAikmn--------------------frvkEYFKS-------- 79   Paramecium te...
Q24DD6         59 IRTFGSLNAGLATGLLGYDGFSGTILYFIFFFIVSFLCLqktg--------------------fkpqNYFLS-------- 110  Tetrahymena t...
CRZ24769       42 SRTCQAAASGMASGILGLTGVSGFIFYFVFVVLQALFWE----MKANfew----------------qnYFTSr------- 94  
XP_002633223   31 GRTCQSCAAGMAAGILGLTGFQGFILYFISVGIQALIWN----VKAQgnw----------------lsYFPE-------- 82  
EEC48737       44 IRSVMGIAAGCVAGIGGLTSWEGLICFLILHVFVCVAVW---AWKMKfql----------------qlYTKLs------- 97  
XP_007417240   36 IKSMTSTISGSLCGILGLTNHLGFLFYLLTSFIVSSLIWfstFIKSKsstss-----------nqslTYFKSs------- 97  
EIM23696       33 IRSTLSMFLGGVAGVLGLTNLYGLIFYLLLAPSLPLLII---TLKTQstq---------------yqsYYKDg------- 87  
KDE09147     2224 VKSTSASISGATAGVLGLTNTFGFLFYLVTSTLIGSLFL---LTKGTaeg----------------kgYFPGdrv----- 2279
XP_014569589   28 IKSTMASISGATAGLLGLTNLSGFAFYIMSSMSVAGLVY---LITTEqqp----------------rkYIKGg------- 81  
EFR02968      107 gggyvrkgaWKDLWFSGLVAteAISGFVLGWA 138 
A0CBX9         80 ---------SYDAYYSGIGT--DLLLFLMIWV 100  Paramecium tetraurelia
Q24DD6        111 ---------ANDVITGGLLG--DLLVFILVWV 131  Tetrahymena thermophila SB210
CRZ24769       95 ----------SLSLTHSLIS--GLFTYILFWV 114 
XP_002633223   83 ----------RNSFTWSHGN--GLLTFVLLWV 102 
EEC48737       98 ---------WFGYLTTSIQP--TALSFTLFWT 118 
XP_007417240   98 ----------YTLWTSSLID--NLFTFILWWT 117 
EIM23696       88 ---------LSEIV---IPTsdSLFGFILVWT 107 
KDE09147     2280 -------saWRTVVLSGLLE--HVFPYILFWT 2302
XP_014569589   82 ---------LPELLLSGLLD--NALSFILFWT 102 
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