Conserved Protein Domain Family
CTNNBL
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pfam08216: CTNNBL 
Catenin-beta-like, Arm-motif containing nuclear
CTNNBL is a family of eukaryotic nuclear proteins of the catenin-beta-like 1 type that contain an armadillo motif. A human nuclear protein with this domain is thought to have a role in apoptosis. The interaction of CTNNBL1 with its known partners (the Prp19-CDC5L complex and AID) is mediated by recognition of NLS (nuclear localization signal) motifs. The RNA-splicing factor Prp31 is also an interactor, with recognition also occurring through the NLS. CTNNBL1 uses its central armadillo (ARM) domain to bind NLS-containing partners.
Links
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Statistics
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PSSM-Id: 462397
Aligned: 84 rows
Threshold Bit Score: 307.555
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q5KD46       1300 EQILDIFDAAGEGEQG---PALDLPALRRQIGKFQRIVLKNAEQRGKYSDDPSKFIDSESDLDTSLKAFLPLTQNPPLfY 1376 Cryptococcus ...
XP_009028187   99 EKVAKILEDDSTES-----DILDEGTVRRLIIQFEKRYQKNQEMRIKYPDAPEKFMESEIELNDTIQEMHMIASMPET-Y 172 
EEY69790       40 AKISAIVDGAEAQEG----DALDARALKSMANSLKKHVRRNALAREKHAYDPTKFLESELALDSELTRWKQVAAKPEL-F 114 
Q8IHX9         12 VDVEEILKQAENI------ECVDENSIKKIGVLLKKKKTKNERDRMEYPEEPEKWVSSEVDLDEILVNLKNLSVCTNL-Y 84   Plasmodium fa...
Q7R9L8          9 IDIDEILKQAENV------ECVDEDSIKKLATVLKKKKNINERDRIEHPDKPEKWVASEVDLDEILVNIKNLSVCTNL-Y 81   Plasmodium yo...
A0CXT5         28 QQDMQFREQNV--------ELFDERQLREMIFQLENNYKLNSDQRMRYPNQPEKFIDSEVDLDEDLRKLLILPAYPQL-Y 98   Paramecium te...
Q22CU9         45 EQLEALINQQAQNQE----AAFDEEVLTKIINQLAVRKTKNEELRSQFANKPEKFQDSEIDLDEIIQKFNSLSAYPEL-L 119  Tetrahymena t...
XP_002130495  110 mkLLEMWEEKVKAKDLndeEQYDDQKVKKLILSFEKKVYKNQEMRIKFPDNPEKFMESELDLNDVVMEMKILATMPEQ-Y 188  vase tunicate
XP_022524306   57 K-ILEKLMDQDEVDPEg--ELVDEAMVKKMILTFEKRSYKNQELRIKFPDNPEKFMEAELDLNDIIQEMHVIATIPEL-Y 132  Mexican tetra
XP_015220133   58 KKLQELMENEDQEDQEa--EPLDESSVKKMILTFEKRSYKNQELRIKFPDSPEKFMESELDLNDIIQEMHVIATMPDL-Y 134  spotted gar

Q5KD46       1377 PELVK-SGIIPIFANLLSHENTDIAMDVVEVIQELTDEDVGgevddlDHEEEtgsetrmaMGQLIDELLNNSLLDLLVSN 1455 Cryptococcus ...
XP_009028187  173 EIVIRgSTTIQTLLQLLNHENTDVSIAVVDLLKEMTDGDVMd-----DNEEE--------AEMLIDALLQGQILALLVQN 239 
EEY69790      115 AVMIE-LQVPRVLLGLFAHENLDIRLAVLSLLGELTDVDDAa-----TSLEP--------ARLLTKHLMDEKLLPLLVSN 180 
Q8IHX9         85 KSMID-SDIFGEIIDLLNHPNNDIVIEVIDIIKEITNPSNIy----eLDKEL--------NDIMIHYLNKKKLCHFLINV 151  Plasmodium fa...
Q7R9L8         82 KSMIE-SDIFGDIINLLNHPNNDIVIEVIDIIKEITNPSNIy----eLNKSV--------NLMLIDYLNKNKLNHFIINT 148  Plasmodium yo...
A0CXT5         99 PIFYS-SNALPIVIQLLLHNNESISNDVIQFLKELVAPE--------SEVEPk------iIIQLYDCLIRNYLIESLGEL 163  Paramecium te...
Q22CU9        120 PKFTE-SSAVVNLLQLLYHENTDIVVDVINFFHEVITMELEk-----KFYDN--------LLKLYFKIVKNKFFESIVAN 185  Tetrahymena t...
XP_002130495  189 HYLVE-LRSVNSLLALINHANTDIAIAVIDLIQELTEVDSVt-----ENEEG--------ANLLADALMDGQAGSLIVQN 254  vase tunicate
XP_022524306  133 HLLVE-LNAVHSLLGLLSHdntdIAIAVVDLLQELTDIDTLh-----ESEEG--------AEVLIDALLEGQVVALLVQN 198  Mexican tetra
XP_015220133  135 HLLVE-LNAVHSLLGLLSHENTDVAIAVVDLLQELTDIDTLh-----ESEEG--------AEVLIDALLEGQVVALLVQN 200  spotted gar

Q5KD46       1456 LSRLDES---E--DTDS--QGVFHILGVFENLLsFMPPLADQIVEETALLQWLLQRIKk------KEYDSNKQYASEIIA 1522 Cryptococcus ...
XP_009028187  240 LERLDETl-kE--EA----QGIHNSLAILENMVeLKPEVSLQAGQQG-FLQWIVNKLKmk-----aPFDDIRLYCSEILS 306 
EEY69790      181 LYQLAAAvenTqaEEET--TGIYNSLQILENMAdLEPQVCVQAAETS-ILPFLLQQVSp-----gRKFSENKLYASEILS 252 
Q8IHX9        152 LDKINEE------ENDEyyNAMTSILNILDNIFeLENDLQNDLLKNSKLLFFLLNRINneik----sddSNSLYASEIFV 221  Plasmodium fa...
Q7R9L8        149 LDKINEE------ESEEyyNAISSILNIFENIFeLENSLQNDLLTNSKLLFFLLKRINneik----sddQNSLYASEILV 218  Plasmodium yo...
A0CXT5        164 IVKNEEK------SQEEv-NLLHDCFEVIENMVdIKSSISKEIGLRSKIIQYLVKRVEdn----sQTLDDNRLYASELLV 232  Paramecium te...
Q22CU9        186 LQRLDEK------VQDEy-DAVHKLLGIIESLLeVNPEYSGQLCSETQFLKWVLKRISpefqlvtKVIDDNKLYLTEILP 258  Tetrahymena t...
XP_002130495  255 LERLDESv-kE--EA----TGVHNSLGVVENLLeLKPEFGLNFAQQG-FVAWLLKRLKak-----iPFSGNKLYASEILS 321  vase tunicate
XP_022524306  199 MERLDETv-kE--EA----DGVHNTLAIVENMAeFRPGLCTEAAQQG-LMQWLLKRIKak-----mPFDANKLYCSEILA 265  Mexican tetra
XP_015220133  201 MERLDEQv-kE--EA----DGVYNTLAITENMAeFRPGLCTEAAQQG-LMQWLLKRIKak-----mPFDANKLYCSEILA 267  spotted gar

Q5KD46       1523 ILLQ---DSRANVLKLGq------------------LD-------GMDVMLQVLSQYLKTDPGDSEEVEFMENVFDSVCS 1574 Cryptococcus ...
XP_009028187  307 ILLQ---MYQENRQILGe------------------VD-------GIDVLLSQLSIFKKHDPSTPEEIEYMENLFNSLCS 358 
EEY69790      253 ILLQ---SGAEPREEFVawtgkdrpsedkttekqgkVD-------LMDDLLQALAPYRKKDPDSEEEEELVGNLVNALCS 322 
Q8IHX9        222 LLILrinQFSQNV-----------------------YDdfyyiisIFNPILKYISKYKDKDPESINKKEILLNYFQALGN 278  Plasmodium fa...
Q7R9L8        219 LLILrinQFAQNV-----------------------YNdfyytisIFNFILKYISKYKDKDPPNINKKEILLNCFQALGN 275  Plasmodium yo...
A0CXT5        233 VLTQ---QTKENLEIIGr------------------SG-------GIESLLMVLNQYRKKDPETAEEKEILNNVYDLLTL 284  Paramecium te...
Q22CU9        259 IIL----SDEENQIRFQk------------------LK-------GIESLLQYLQSYEKKDPTCEEEKETFLNVVDCLCL 309  Tetrahymena t...
XP_002130495  322 ILLQ---SHDEIRKLVGe------------------LE-------GIDILLQQLAAFKRHDPKGAEEVEFMENLFNCLCS 373  vase tunicate
XP_022524306  266 ILLQ---NNDSTRELLGe------------------LD-------GIDVLLQQLSVFKRHNPSTAEEQEMMENLFDALCS 317  Mexican tetra
XP_015220133  268 ILLQ---NNDSTRELLGe------------------LD-------GIDVLLQQLSVFKRHNPSTAEEQEMMENLFDSLCS 319  spotted gar

Q5KD46       1575 SLAQPEMKKAFFDAEGVELMVLMMKE-KRLAKTRAIKVLDYALQtESGSPACERFVQALGLKTFFSAFMssasskaggkk 1653 Cryptococcus ...
XP_009028187  359 SLMLPTNRTRFLKGEGLQLMNLLLREkKKLCRTSAIKVLNHSMVgSEGVDNCNKFIDILGLRTIFPLFMk---------- 428 
EEY69790      323 VLLVPEAQTQFRRLEGLELLLRFMKDrKRFVFSGALRAMDHALM--ASARNCERLIEIGGLRSVFSVFMgrhg----kyk 396 
Q8IHX9        279 LLLLNKNKNVFQNTIGFELMLKLLSE-RKFLCFPSLKIFAILLN---DIETCNKFIEMNGLKYLFCLFMl---------- 344  Plasmodium fa...
Q7R9L8        276 LLLLNENKKIFESANGLELMLKLLSE-RKFLCFPSLKIFAIVLT---NKDVCNKFVELSGLKYLFCLFMl---------- 341  Plasmodium yo...
A0CXT5        285 LLIQEENQEYFQSYEGLQLMIKIIQG-KTSQSIRAYSLMLLAIN--NHKENCQKLISIGGLSIIFPILEr---------- 351  Paramecium te...
Q22CU9        310 FLVQRNYQEVFRNSDGIQLMIKLITA-KNYSSKSALRILSYALV--NNEQNCLKFVDLQGLKFAFPILM----------- 375  Tetrahymena t...
XP_002130495  374 SLLLVDNRSKFLHGEGLQLMNLMLRE-KKMSRNSALKVLDHAMSgPDGASNSAKFVDILGLRTLFPIFMk---------- 442  vase tunicate
XP_022524306  318 CLMLPANRDRFLRGEGLQLMNLMLRE-KKLSRTSSLKVLDHGMIgPEGSDNCHKFVDILGLRTIFPLFMk---------- 386  Mexican tetra
XP_015220133  320 CLMLAANRDRFLKGEGLQLMNLMLRE-KKMSRMSALKVLNHAVIgPEGSDNCHKFVDILGLRTIFPLFMk---------- 388  spotted gar

Q5KD46       1654 sKSKlgaaaATSAIEDeEHMLGILASLFTNLASDS--PERIRVIAKFVEGGYEKVERLLEVREAAEGRLGSVIKEIEYER 1731 Cryptococcus ...
XP_009028187  429 -PPHvhkkaGPNKQELeEHIVSIVASLVQNSEGSQ----RQRLLNKFTENDHEKVDRLMELHFKYLQRAEAVEADIEKQR 503 
EEY69790      397 sSGStkasqASEKAKEeENAASLVASMCAWVSEKApaDGYSRLHAKFVENDMEKVDRLVDLFAKYQERVERSQNEE---- 472 
Q8IHX9        345 --RDikkqnHMSVFEFeENIIIIISNLSLFCTGTF----QGRVLSKFGEKKCEKIIRLLEIRQKYHEIIIKDKKKKQKNK 418  Plasmodium fa...
Q7R9L8        342 ---RtlnksKTNTLEFeENIITIISNLCIYCTGTS----LGRVLNKFGEKKCEKIIRLLEIRQKYSDIIIN-EKKKEKDK 413  Plasmodium yo...
A0CXT5        352 --KGlkhkdKNKQFEIdETSVQIIKQLLRRNTDAA---FKQRVFDKCVE----KLESLKKLRMEYVEVIPLIDPEEYDN- 421  Paramecium te...
Q22CU9        376 -KKGikakkPEDAQKIeEQITSIIKNIIKETTAIQ----QDRVINKFRE-DIIKVDRLFELHEQYQKVMKLIEYKMQDPA 449  Tetrahymena t...
XP_002130495  443 -PPKknkkvGSSRKDHeEHVISIISSMLQNLSGSH----RQRLIAKFTENDFAKVDRLMELHFKYYERVQRVDNRLDAER 517  vase tunicate
XP_022524306  387 -TPKkmrktGISDKEHeEHVCSIMASMLRNLKGQQ----RSRLLSKFTENDCEKVDRLMELHFKYLEAVQLADRRIEGEK 461  Mexican tetra
XP_015220133  389 -TPKrmkkaGLSDKEHeEHVCSIIASMLRNLKGQQ----RTRLLSKFTENDCEKVDRLMELHFKYLEAVQLADKKIEGEK 463  spotted gar

Q5KD46       1732 EVMQAneEe-----ITDveETEWYLRKMDAGLASLQNADYVLAWVCM--------------EDDGAMTHARLLLSRKNMN 1792 Cryptococcus ...
XP_009028187  504 EAIQSqgRs-----LTAddEDEFYMNKLEAGLFTLQLVDYIIVEACLl-------------CPDTVRGRVMQILNLRGGT 565 
EEY69790      473 --------------EEEedDDSRYLRRLDAGLFVLERTAFVVAHLCQ--------------FSKKVRAYVMVKFHERSID 524 
Q8IHX9        419 NQVNEnlKkmniqiDEDskKDLEYIELCDKGYLIYQLTDVILIALFYm-------------NNTYICNNIFIHLYTRNID 485  Plasmodium fa...
Q7R9L8        414 LLINKnlQklniqiDDDckKNLEYIELCDKGYLTYQLTDVILISLFFm-------------NNSYISNNIFIHLYTRNID 480  Plasmodium yo...
A0CXT5        422 --------------FEEkqLEKIYFDLLGKGLIVIESIDVILLELIYkdld-------vqiDQQEIISSVKQMLKYTGEK 480  Paramecium te...
Q22CU9        450 YLKTLeeF------EAQnvEETIYRQKLDEGLSILENVDFIIAFLNQckdelvsakvkkniKVHQLRDEILGVLVQNKQH 523  Tetrahymena t...
XP_002130495  518 TRLLVegE------DEEeiEEDFYLRRLDAGLFTLQQTDYVLVDICAs-------------GSSSIKQRVLQILNLRSGS 578  vase tunicate
XP_022524306  462 HEMVRrgEi-----LDDamEDEFYLRRLDAGLFVLQLICYIMVEISSa-------------GIPQLQQRVHQILNLRGGS 523  Mexican tetra
XP_015220133  464 HDMVRrgEi-----IDDtmEDEFYLRRLDAGLFVLQLLCYIMVEISSa-------------GIPQLQQRVHQILNLRGGS 525  spotted gar

Q5KD46       1793 FK-TIAA---VLT 1801 Cryptococcus neoformans
XP_009028187  566 VQ-TIKN---IMK 574 
EEY69790      525 SE-SLVA---VLR 533 
Q8IHX9        486 IQ-SIYE---NIL 494  Plasmodium falciparum 3D7
Q7R9L8        481 IQ-SIYE---NIL 489  Plasmodium yoelii yoelii
A0CXT5        481 E--DIDYynpLLQ 491  Paramecium tetraurelia
Q22CU9        524 FDpSAKNkkrKMF 536  Tetrahymena thermophila SB210
XP_002130495  579 VK-SIRT---IIR 587  vase tunicate
XP_022524306  524 VK-AVRH---IMR 532  Mexican tetra
XP_015220133  526 VK-VVRH---IMR 534  spotted gar
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