6FF7,5YZG


Conserved Protein Domain Family
Isy1

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pfam06246: Isy1 
Isy1-like splicing family
Isy1 protein is important in the optimization of splicing.
Statistics
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PSSM-Id: 461860
Aligned: 96 rows
Threshold Bit Score: 134.64
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6FF7_w         2 ARNAEKAMTALARFRQAQLEEGKVKE----RR--PFLASECTELPKAEKWRRQIIGEISKKVAQIQNAGL------GEFR 69 
Q59R35         2 SRNKEKAQSSLNRFY--QSQSSAPINyhyhQR--PKNIHSITQLSQAEGWRRSIIGEISKQLTEINDFEI------SDIK 71  Candida albican...
XP_002550851   2 SRNKEKAQSNLNQYYLQKDRVSGVLDsnsqNR--PKNVNKVTSLPQAEKWRSIVISEISINLTKINDENL------TDFE 73 
XP_001385616   2 SRNKEKAQSALNRFQEFKNREAGVLEsnpsLR--PKRADTVNYLPQARKWKSVVMSEISTKMTDINDPNA------TELQ 73 
EGV61991       2 SRNKEKAQSALNRYQQEVNRQAGVLEtnpnLR--PKYVQSVESLPQAEKWRSVVITEISTRLTRIQDPLL------EESQ 73 
XP_001482604   2 SRNTEKAQSALNRFQLAKSRSAGVLEsnpqLR--PKYVQLVKNLPQAEKWRSVVIGEISTNLTRIQDPNI------NHVQ 73 
Q6BU51         2 SRNTEKAQSSLNRFQALKNKEAGVLEsnpnFR--PKYVQSVDSLPQAEKWRSTIIGEISVKLTKIQDPAL------NEYQ 73  Debaryomyces ha...
CCE81173       2 SRNTEKAQAALNRYQALKNKEAGVLEsnpsLR--PKNVSSVTSLPQAERWRSIVIGEISVKQTQINDPIL------NDYQ 73 
CAY71246       2 SRNSEKANSLLNRYHRQKNVLPVTGD----AR--PKRVQSVKDLRVAEKFRLLCVQEISQKISRINDVSL------NDYQ 69 
Q4QIU3        50 ARTKERKNTILYKLSKRRQEEERLARl--gVErlPTNPSEVDDEKIIKYVLFRLKQEIGDKTAQLRDQKLlsidrdGEAV 127 Leishmania major
6FF7_w        70 IRDLNDEINKLLREKGHWEVRIKE-LGG---PDYGK----VGPKMLDHeGKEV------PGNRGYKYFGAAKDLPGVREL 135
Q59R35        72 VRELNDQLNELFNEKRRWEYHIRDkLHG---NDYIRhngnTKNDLINT-GIRVnns---dkgKYYRYFGRAKDLPEVKLM 144 Candida albican...
XP_002550851  74 IREINDKLNLLFKEKKSWEYHIRNnLKG---NDYIK----YGKDLMNT-GVLVdrddnsV--KGYRYFGRAKELPDVKAL 143
XP_001385616  74 LRDLNDKLNKLFWEKENWESQINI-LSG---GNPNR----I-RRNRRY-GQKApad--seyEPGYQFFGRARELPDAKKF 141
EGV61991      74 IRELNETLNKLMSEKRAWEHHIKS-LGG---ADYLRf---G-PKFESM-GMMDndi---sgIKGFRYFGRAKDLPEVKLL 141
XP_001482604  74 IRDINEHLNKLFREKRAWEHHIKL-LGG---ADY----------------TLLsggdagIKVKGYRYYGRSRELPDVQEM 133
Q6BU51        74 IRDINDSLNKLFNEKRSWEYHIKN-LGG---ADYMHf---N-KDFNNA-GKLSqldssgSHIKGYRYFGRAKELPDVKEV 144 Debaryomyces ha...
CCE81173      74 IRDLNDAINKLLREKRSWEYRIRE-LGG---PDYLSf---G-ANMGNA-GVYTgvdttgTKVKGYRYFGRAKELPELKDM 144
CAY71246      70 IRDLNDELNKLTKERFAWEYHIKE-LGG---PNYI-------LNSNKA-MSSVnvd-----ssgYRYFGRAKDLPDVKQM 132
Q4QIU3       128 IRAKNDEVNKLLSRKYQWEARLSF-LAGepiAPRPR--------------KKI-------------FFGCAKELPEASVV 179 Leishmania major
6FF7_w       136 FEKEP------------LP-----PPRK---TRAEL-----MKA-IDFEYYGY--------------------------- 162
Q59R35       145 IEENKknrknhkrddidDSd---qSKRR-----RKVdqyksTDNsIDMNYYGFydee----------------------- 193 Candida albican...
XP_002550851 144 IEQKRkrtki---kqidYNe---dKARE---ER------------LGFAYYGYy-------------------------- 176
XP_001385616 142 LENERlek-------qrtSe---rKRKA---ESTDQsvkrlNQR-IDLAYYGYydedpcnfgtrnifnkqereqiielah 207
EGV61991     142 QQAKIdka-------treSt---qQDTE---QREVQelemrFSN-LDPTYYSTftrtniydkaed--------------- 192
XP_001482604 134 LKQTEeae-------kkkNs---qHSEK---QEFEVrlqkrRER-LGPFYYGCfdgdsssfptk---------------- 183
Q6BU51       145 LMLQQkkg-------hanKs---kHAKE---LEQNRllneqDQR-IKADYYGVydeindgnddiiasnerdiinq-vnev 209 Debaryomyces ha...
CCE81173     145 IAAQQnlk-------aanSn---rLKDH---EIKEKvlnerQAR-LTDEYYGLnepgsethncastrdtiqndl---sda 207
CAY71246     133 LEARKkhk-------teqEtqiqvAKDK---KLRLRlleesKEK-LPLSYFGVvnttv---------------------- 179
Q4QIU3       180 QKRQRvegmqeagedevADs---sEEDElvpDQLEAeqpatQDH----DY------------------------------ 222 Leishmania major
6FF7_w       163 -----------------LDED----------D-G---VIVPLEQEYEKKLRAELVekwkaerearlargekeeeeeeeee 211
Q59R35       194 -------------edeyLDDS----------EaQlgdPLVVYEEKRTKELNDAEI------------------------- 225 Candida albican...
XP_002550851 177 -----------------DEKElpldiigfekKsTvsdPLLEFESQRSKELSEDTNdtqh--------------------- 218
XP_001385616 208 klgeedfeiedetdygvRDDI----------E-NindRILRYEGCIKEERFYSSLddpsds------------------- 257
EGV61991     193 -----dliaivgdvytrQEER----------K-N-------VEAYNFKAISKSLSddiqn-------------------- 229
XP_001482604 184 ------kdvekelgytnEEKH----------Y-RidsELQAYEETRSQELGKELSenqe--------------------- 225
Q6BU51       210 lgdeiikpvddineyyvAHKA----------Q-GvdnLIE-FEKNRGKKLFRKFKnnqhndea----------------- 260 Debaryomyces ha...
CCE81173     208 lnsvsflsqdlgdnykmENKH----------Sn---tLLE-FENKRGIEILKSRSardrdgpas---------------- 257
CAY71246     180 -------------eetsHTDA----------Q-GqdeELLEYESRLTTERRRKLNvqfsg-------------------- 215
Q4QIU3       223 -----------------LERVkwlgssaadlD------LIRFEREAEAKMRAKGDsivsr-------------------- 259 Leishmania major
6FF7_w       212 iniyavteeesdeegsqekggddsqqKFIA---------HVP-VPSQQEIEEALVRRKKMELLQK 266
Q59R35       226 --------------------------QQQDtenleqirmSFNdIPTNEVVTKWLVNKRREQLLSK 264 Candida albicans SC5314
XP_002550851 219 -----------------------------------nkiiNFDdIPTNEMVTKWLVNKKRQELLAK 248
XP_001385616 258 ---------------------------------imriqdFELeVPSSQHVQQWMLTKRKKELLAK 289
EGV61991     230 ----------------------takdMTISqaqleeimdYSDiIPSEEDIKQWVLDQKKQQLLAK 272
XP_001482604 226 -----------------------------------feghFEDlVPTSEQVSRWIVEERKRKLMER 255
Q6BU51       261 --------------------------------dsnvitnFEKeVPTSDEVTKWIVNKKRAELIAR 293 Debaryomyces hansenii CBS767
CCE81173     258 -------------------------------ddvedivdFEKeVPTGEEVKAWIVQKKKAELINR 291
CAY71246     216 ----------------------astrSddev----sllhLK--IPESSAIEKYIIQKKKEKLLSs 252
Q4QIU3       260 ----------------------agsgALILsycke----gkamIPDEEHFKQQLVNNRKKALQER 298 Leishmania major
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