1AKH,1B72,1FJL,1BW5,1B72,1NK2,1OCP,1CQT,2LFB


Conserved Protein Domain Family
homeodomain
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cd00086: homeodomain 
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Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Links
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Statistics
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PSSM-Id: 238039
Aligned: 317 rows
Threshold Bit Score: 31.4449
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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specific DNADNA binding
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:specific DNA base contacts [nucleic acid binding site]
Evidence:
  • Comment:sequence specific interactions with major and minor groove nucleotides
  • Comment:position of residues interacting with minor groove (helix1) are shifted in subgroups
  • Citation:PMID 9154919
  • Structure:1AKH; MATalpha1
  • Citation:PMID 7569974
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #                                                  #  ##  #      
1AKH_B       3 PYRGHRFTKENVRILESWFAkni---enPYLDTKGLENLMKNTS-----LSRIQIKNWVSNRRRKEKTIT 64   baker's yeast
4138131    731 KRKRTIMNDEQVMLIERALLde----pdMQRNAASLQSWADKLSlhgsdVTPSQIKNWLNNRKARLARTA 796  Lotus japonicus
7510366    460 PKPKSQYSKFEDETMEKAYMrtvkmnpsSYESRDLLESISISLR-----MSLIKVHEWFNNRKFVDSVSI 524  Caenorhabditis elegans
NP_598305    3 AQTGSGPTEDQVEILEYNFNkv-----nKHPDPTTLCLIAAEAG-----LTEEQTQKWFKQRLAEWRRSE 62   Norway rat
AAC12733   240 EQKRSTFTPDQLEALEQAFNrg-----hYPTDPFNRDNMSNKVD-----LSQTRVQDVKPSISCSTTSVA 299  Florida lancelet
544148     582 LSPGQPPLKNLLSLLKAYYAl------nAQPSAEELSKIADSVN-----LPLDVVKKWFEKMQAGQISVQ 640  chicken
7503266    318 EKNWSSFSYDAIHFLEQEYRk------tKYISSTDCQKISEKIH-----LDEELIEKWFRARRATSKREA 376  Caenorhabditis elegans
O60315     645 MTSPINPYKDHMSVLKAYYAm------nMEPNSDELLKISIAVG-----LPQEFVKEWFEQRKVYQYSNS 703  human
7503437    464 ERKRTSNLDYASRILEQKFAn------rANLLPSDLVDLEKTIG-----WTLDEISEWFETREKLQERRE 522  Caenorhabditis elegans
NP_196688  283 WSAQKRVKKAHIETLEKVYRr------sKRPTNAVVSSIVQVTN-----LPRKRVLKWFEDKRAEDGVPD 341  thale cress

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