Conserved Protein Domain Family
WAP

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cl00156: WAP Superfamily 
whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.
Links
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Taxonomy: root
PubMed: 9 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00156
PSSM Id: 469631
Name: WAP
Created: 8-Feb-2008
Updated: 4-Oct-2023
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