2LKT


Conserved Protein Domain Family
LRAT
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pfam04970: LRAT 
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Lecithin retinol acyltransferase
The full-length members of this family, eg Swiss:P53816, are representatives of a novel class II tumour-suppressor family, designated as H-REV107-like. This domain is the catalytic N-terminal proline-rich region of the protein. The downstream region is a putative C-terminal transmembrane domain which is found to be crucial for cellular localization, but not necessary for the enzyme activity. H-REV107-like proteins are homologous to lecithin retinol acyltransferase (LRAT), an enzyme that catalyzes the transfer of the sn-1 acyl group of phosphatidylcholine to all-trans-retinol and forming a retinyl ester.
Links
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Statistics
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PSSM-Id: 398571
Aligned: 32 rows
Threshold Bit Score: 76.1803
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2LKT_A         19 LGYEHWALYIGDGYVIHLAPPS-------------EYPGAGSS------SVFSVLSNSAEVKRERLEDVVGGCCYRVNNS 79  human
Q0KA82         31 RGYVHHGIYVGNGEVVHY-------------------------------VGFKGFLRCGPVEKTTLAGFAGGYGFRVEPA 79  Cupriavidus ne...
WP_012001643   21 KLYEHHGIYVGDDMVVHYNGLAhgivl---ekscfEEILSN--------VVPLDKRNIAKVEMTSLEEFASGDVLQVKKH 89  Campylobacter ...
EAQ75782       14 GLFNHHGIDLGDGSVAHYL-------------------------------------EGRAILRSPLEDFSRGEPVAVVAY 56 
EAW34436       18 GVYEHHGIDCGDGSVIHYRKPS------------------------------------EIVERTSMETFARGGKVYIRPY 61 
jgi:Noca_4647  13 RRYTHHGIDCGDGSVIHYA---------------------------------GPRGSVRRVTRSPIDSFAAGSPVLVRAY 59 
Q8L9G9         26 YIYAHHGIYVGNGQVNHFTRGDgqetgtgtfldniIVSSSHNHgdn-pcPDCGDRSNLGGVISSCLECFLAGGDLYVFEY 104 thale cress
Q0DJA1         27 YLYAHHGIYIGDAMVIHFTRATgheigtgtfldmfLFSSSPATeegppcEKCGHLIKQQGVIMSCLDCFLDGGNPYLFDY 106 Japanese rice
XP_006660866   26 YAYSHHGIYVGGSKVVHFTRKKeaesgsdssnstsSLLLESSSecp-tfPDCGFQLPDSGVVLTCLDCFLRNGSLYCFEY 104
Q8LBP8         26 FAYSHHGIFVGGSKVVHFRPEHnpmdsstssisssSSEDICSIf-----PDCGFRQPDSGVVLSCLDCFLKNGSLYCFEY 100 thale cress

2LKT_A         80 LDHEYQ--------------PRPVEVIISSAKE--MVGQkMKYSIVSRNCEHFVTQLRYGKS 125 human
Q0KA82         80 TQARYV-----------------EAEIVRRATA--RLGE-DDYRLLTNNCEHFCIWCLSGES 121 Cupriavidus necator H16
WP_012001643   90 ADa-----------------PFSGQEVALRAKE--RIGE-QKYNLIINNCEHFCNECVFGEH 131 Campylobacter concisus
EAQ75782       57 DPDEIS----------------AAGMTLRRAMG--RLGE-QRYNLIFNNCEHFAIWCKTGRH 99 
EAW34436       62 PV------------------RYIPDTVIQRAEN--RLGE-CKYNLLFNNCEHFATWCVTGVN 102
jgi:Noca_4647  60 EQ------------------RLSPEETVRQAES--RLGS-MGYHLVRNNCEHFAAWCCTGRA 100
Q8L9G9        105 SVSPAIflakprggvctiasSDPPEEVIYRANFllQNGF-GVYNVFKNNCEDFAIYCKTGLL 165 thale cress
Q0DJA1        107 AVSPAFflvkarggtctlaaSDPADIVIHRAQHllNSGF-GTYSLFKNNCEDFAIYCKTGLL 167 Japanese rice
XP_006660866  105 GVPSAVflaklrggtctiaqSDPPEVVVHRAMYllQNGF-GNYDIFENNCEDFALYCKTGLL 165
Q8LBP8        101 GVSPSVfltkvrggtcttaqSDTTDSVIHRAMYllQNGF-GNYDIFKNNCEDFALYCKTGLL 161 thale cress
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