1NY4,1NE3


Conserved Protein Domain Family
S1_S28E

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cd04457: S1_S28E 
Click on image for an interactive view with Cn3D
S1_S28E: S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control precursor RNA splicing and turnover in mRNA maturation process but its function in the ribosome is largely unknown. The structure contains an OB-fold found in many oligosaccharide and nucleic acid binding proteins. This implies that S28E might be involved in protein synthesis.
Statistics
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PSSM-Id: 239904
Aligned: 36 rows
Threshold Bit Score: 77.6755
Created: 15-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
RNA binding
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:RNA binding residues of the RNA PolymeraseII RPB7 subunit, confirmed by mutagenesis

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #               #             # #                        
1NY4_A     7 YPAEVIEIIGRTGTTGDVTQVKVRIlegrdkGRVIRRNVRGPVRVGDILILRETEREAREIK 68  Pyrococcus horikoshii
1NE3_A     5 TPAEVIEVLKRTGMTGEVMQVKCRIldgrdkGRILTRNVMGPIREGDILMLLDTIREAKEIR 66  Methanothermococcus thermolithotrophicus
AAM04936  13 FAAEVIDVIGNTGMHGEASQIQCRVlegrdkGRVITRNCVGPVRIGDILMLLETSREAKKLT 74  Methanosarcina acetivorans C2A
CAC12242   6 TPAEVVEIIGRTGMTGEATTVKVRVlagrdqGRIIARNVLGPVRVGDILMLMETAREAKKLS 67  Thermoplasma acidophilum
O29493     8 QPAEVVELVGRTGMHGEVTQVKVRVlagenkGRVITRNVFGPVKVGDIIMIKETAREARKLA 69  Archaeoglobus fulgidus
YP_447673  5 TPAEVIEVLKRTGMTGEVMQVKCRIldgrdkGRILTRNVMGAIKEGDVLMLLDTIREAKEIR 66  Methanosphaera stadtmanae DSM 3091
P57710    11 TPAEVIEVVGKTGMHGEAMQVKCRIqeggnqGRIITRNVLGPVRVGDVIQLKETAREADSIG 72  Halobacterium salinarum
CAC26980   6 KLAKVIKIIGKTGSRGGITQVKVEFld--dkSRTLIRNVKGSVREGDILVLIESEREARKIK 65  Guillardia theta
XP_955679  7 FFGEVTHVLGRTGGSGLLTQVKMELmh---nKRTIQRAVKGPVAVGDIIEILECEREHRRTR 65  Encephalitozoon cuniculi GB-M1
CAK58350  11 TRATVIEIIGRTGSRGGITQVKVQLvg---qQRTLIRNVMGPVRKGDTLELMECEREARRLR 69  Paramecium tetraurelia

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