Conserved Protein Domain Family
ENaC
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TIGR00859: ENaC 
sodium channel transporter
The Epithelial Na+ Channel (ENaC) Family (TC 1.A.06)The ENaC family consists of sodium channels from animals and has no recognizable homologues in other eukaryotes or bacteria. The vertebrate ENaC proteins from epithelial cells cluster tightly together on the phylogenetic tree: voltage-insensitive ENaC homologues are also found in the brain. Eleven sequenced C. elegans proteins, including the degenerins, are distantly related to the vertebrate proteins as well as to each other. At least some ofthese proteins form part of a mechano-transducing complex for touch sensitivity. Other members of the ENaC family, the acid-sensing ion channels, ASIC1-3,are homo- or hetero-oligomeric neuronal H+-gated channels that mediate pain sensation in response to tissue acidosis. The homologous Helix aspersa(FMRF-amide)-activated Na+ channel is the first peptide neurotransmitter-gated ionotropic receptor to be sequenced.Mammalian ENaC is important for the maintenance of Na+ balance and the regulation of blood pressure. Three homologous ENaC subunits, a, b and g, havebeen shown to assemble to form the highly Na+-selective channel.This model is designed from the vertebrate members of the ENaC family. [Transport and binding proteins, Cations and iron carrying compounds]
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Statistics
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PSSM-Id: 273304
Aligned: 17 rows
Threshold Bit Score: 592.859
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O13263    25 TLYELMQWYCLN-----------------------TNTHGCRRIVVSK-GR----LRRWIWIVLTLIAVALIFWQCALLL 76  African clawed frog
P55270    34 SYRELFEFFCNN-----------------------TTIHGAIRLVCSQhNR----MKTVFWAVLWLCTFGMMYWQFGQLF 86  cattle
P37088    54 SYRELFEFFCNN-----------------------TTIHGAIRLVCSQhNR----MKTAFWAVLWLCTFGMMYWQFGLLF 106 human
Q92075    46 SYQDVFQFFCSN-----------------------TTIHGAIRLVCSKkNK----MKTAFWSVLFILTFGLMYWQFGILY 98  chicken
P51167    18 SYRELFEFFCSN-----------------------TTIHGAIRLVCSRrNR----MKTAFWLVLFLVTFGLMYWQFGLLF 70  African clawed frog
P51172    55 SFRELLTFFCTN-----------------------ATIHGAIRLVCSRgNR----LKTTSWGLLSLGALVALCWQLGLLF 107 human
AAA75459  21 TYKELLVWYCDN-----------------------TNTHGPKRIICE--GP----KKKAMWFLLTLLFAALVCWQWGIFI 71  human
P37090    21 TYKELLVWYCNN-----------------------TNTHGPKRIICE--GP----KKKAMWFLLTLLFACLVCWQWGVFI 71  Norway rat
CAA74979  29 PVAVAAARQPGGdrsgdpalqgpgvarrgrpslsrTKLHGLRHMCAGRtAAggsfQRRALWVLAFCTSLGLLLSWSSNRL 108 Norway rat
P55926    17 SIQAFASs---------------------------STLHGLAHIFSYErLS----LKRALWALCFLGSLAVLLCVCTERV 65  Norway rat

O13263    77 MTYYS--VSASIT-VTFQKLVYPAVTICNLNPYSYSKIKDRLATLEKTTNQTLKKIYGFTEPLIRSKRDLDVndensted 153 African clawed frog
P55270    87 GEYFSypVSLNIN-LNSDKLVFPAVSICTLNPYRYKEIQEELEELDRITEQTLFDLYKYNSSKTLVAHARSR-------- 157 cattle
P37088   107 GEYFSypVSLNIN-LNSDKLVFPAVTICTLNPYRYPEIKEELEELDRITEQTLFDLYKYSSFTTLVAGSRSR-------- 177 human
Q92075    99 REYFSypVNLNLN-LNSDRLTFPAVTLCTLNPYRYSAIRKKLDELDQITHQTLLDLYDYNMSLARSDGSAQFs------- 170 chicken
P51167    71 GQYFSypVSINLN-VNSDKLPFPAVTVCTLNPYRYKAIQNDLQELDKETQRTLYELYKYNSTGVQGWIPNNQr------- 142 African clawed frog
P51172   108 ERHWHrpVLMAVS-VHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARENIDSLYNVNLS--------KG-------- 170 human
AAA75459  72 RTYLSweVSVSLS-VGFKTMDFPAVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNfsi------ 144 human
P37090    72 QTYLSweVSVSLS-MGFKTMNFPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDKILAPKSSHTNTTSTLNfti------ 144 Norway rat
CAA74979 109 LYWLSfpSHTRVHrEWSRQLPFPAVTVCNNNPLRFP----RLSKGDLYYAGHWLGLLLPNRT------------------ 166 Norway rat
P55926    66 QYYFCyhHVTKLDeVAASQLTFPAVTLCNLNEFRFS----QVSKNDLYHAGELLALLN--N------------------- 120 Norway rat

O13263   154 iflkQIPLFRLESIKGNQLVVSDLKTkKrtQISGKVIQRDAGSVQDS--DNMVGFKLCDaNNSSDCTIFTFGSGVNAIQE 231 African clawed frog
P55270   158 ----RDLREPLPHPLQRLPVPAPPHAaR--GVRRAGSSMRDNNPQVNrkDWKIGFQLCN-QNKSDCFYQTYSSGVDAVRE 230 cattle
P37088   178 ----RDLRGTLPHPLQRLRVPPPPHGaR--RARSVASSLRDNNPQVDwkDWKIGFQLCN-QNKSDCFYQTYSSGVDAVRE 250 human
Q92075   171 ---hRRTSRSLLHHVQRHPLR------R--QKRDNLVSLPENSPSVDknDWKIGFVLCS-ENNEDCFHQTYSSGVDAVRE 238 chicken
P51167   143 ---vKRDRAGLPYLLELLPPG------S--ETHRVSRSVIEEELQVKrrEWNIGFKLCN-ETGGDCFYQTYTSGVDAIRE 210 African clawed frog
P51172   171 -------RAALSATVPRHEPP-----------FHLDREIRLQRLSHSgsRVRVGFRLCN-STGGDCFYRGYTSGVAAVQD 231 human
AAA75459 145 --wnHTPLVLIDERNPHHPMVLDLFG-D--N-HNGLTSSSASEKICNahGCKMAMRLCS-LNRTQCTFRNFTSATQALTE 217 human
P37090   145 --wnHTPLVLIDERNPDHPVVLNLFG-D--S-HN--SSNPAPGSTCNaqGCKVAMRLCS-ANGTVCTFRNFTSATQAVTE 215 Norway rat
CAA74979 167 ---------------ARPLVS----------------------------------------E-LLRGDEPRRQWFRKLAD 190 Norway rat
P55926   121 ----------------RYEIP----------------------------------------D-TQMADEKQLEILQDKAN 143 Norway rat

O13263   232 WYRLHYNNILAK-ISMEDKIAMGYKADELIVTCLFDGLSCDARNFTLFHHPLYGNCYTFNSAe--rGNLLVSSMGGAEYG 308 African clawed frog
P55270   231 WYRFHYINILSRrRQDTSPSLEEDVLGKFIFTCRFNQDSCNEANYSHFHHPMYGNCYTFNDKn--sSNLWMSSMPGVNNG 308 cattle
P37088   251 WYRFHYINILSR-LPETLPSLEEDTLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFNDKn--nSNLWMSSMPGINNG 327 human
Q92075   239 WYSFHYINILAQ--MPDAKDLDESDFENFIYACRFNEATCDKANYTHFHHPLYGNCYTFNDn---sSSLWTSSLPGINNG 313 chicken
P51167   211 WYRFHYINILAR--VPQEAAIDGEQLENFIFACRFNEESCTKANYSSFHHAIYGNCYTFNQNqsdqSNLWSSSMPGIKNG 288 African clawed frog
P51172   232 WYHFHYVDILAL-LPAAWEDSHGSQDGHFVLSCSYDGLDCQARQFRTFHHPTYGSCYTVDG-------VWTAQRPGITHG 303 human
AAA75459 218 WYILQATNIFAQ-VPQQELVEMSYPGEQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGm--tEKALPSANPGTEFG 294 human
P37090   216 WYILQATNIFSQ-VLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWGm--tEKALPSANPGTEFG 292 Norway rat
CAA74979 191 FRLFLPPRHFEG-ISAAFMDRLGHQLEDMLLSCKYRGELCGPHNFSSVFT-KYGKCYMFNSGed-gKPLLTTVKGGTGNG 267 Norway rat
P55926   144 FRSFKP-KPFN---MREFYDRAGHDIRDMLLSCHFRGEACSAEDFKVVFT-RYGKCYTFNSGqd-gRPRLKTMKGGTGNG 217 Norway rat

O13263   309 LKVVLYIDEDEYNPYLST------AAGAKILVHDQDEYPFIEDLGTELETGTETSIGMQLTESTKLSDPYSDCTIDGSDI 382 African clawed frog
P55270   309 LSLTLRTEQNDFIPLLST------VTGARVMVHERDEPAFMDDAGFNLRPGVETSISMSKEAVDRLGGDYGDCTKNGSEV 382 cattle
P37088   328 LSLMLRAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGSDV 401 human
Q92075   314 LSLVVRTEQNDFIPLLST------VTGARVMVHDQNEPAFMDDGGFNVRPGIETSISMRKEMTERLGGSYSDCTEDGSDV 387 chicken
P51167   289 LTLVLRTEQHDYIPLLSS------VAGARVLVHGHKEPAFMDDNGFNIPPGMETSIGMKKETINRLGGKYSDCSEDGSDV 362 African clawed frog
P51172   304 VGLVLRVEQQPHLPLLST------LAGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPYGHCTAGGEGV 377 human
AAA75459 295 LKLILDIGQEDYVPFLAS------TAGVRLMLHEQRSYPFIRDEGIYPMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEV 368 human
P37090   293 LKLILDIGQEDYVPFLAS------TAGARLMLHEQRTYPFIREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDV 366 Norway rat
CAA74979 268 LEIMLDIQQDEYLPIWGEteettfEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGL 347 Norway rat
P55926   218 LEIMLDIQQDEYLPVWGEtdetsfEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDS 297 Norway rat

O13263   383 SVENLY---NKKYTLQICLNSCFQREMVRSCGCAHYDQPLPNGAKYCNYEEYPNWIYCYVKLYKQFVQEELGCQSTCRES 459 African clawed frog
P55270   383 PVENLY---NTKYTQQVCIHSCFQESMIKECGCAYIFYPRPDGVEFCDYRKHNSWGYCYYKLQDAFSSDRLGCFTKCRKP 459 cattle
P37088   402 PVENLY---PSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKP 478 human
Q92075   388 PVQNLY---SSRYTEQVCIRSCFQLNMVKRCSCAYYFYPLPDGAEYCDYTKHVAWGYCYYKLLAEFKADVLGCFHKCRKP 464 chicken
P51167   363 DVKNLF---QSEYTEQVCVRSCFQAAMVARCGCGYAFYPLSPGDQYCDYNKHKSWGHCYYKLIIEFTSNKLGCFTKCRKP 439 African clawed frog
P51172   378 EVELLH---NTSYTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRP 454 human
AAA75459 369 PVQNFYsdyNTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRET-CIGMCKES 447 human
P37090   367 AIQNLYsdyNTTYSIQACLHSCFQDHMIHNCSCGHYLYPLPAGEKYCNNRDFPDWAYCYLSLQMSVVQRET-CLSMCKES 445 Norway rat
CAA74979 348 DFFP-------VYSITACRIDCETRYIVENCNCRMVHMP--GDAPFCTPEQHKECAEPALGLLAEKDSN----YCLCRTP 414 Norway rat
P55926   298 DFFD-------SYSITACRIDCETRYLVENCNCRMVHMP--GDAPYCTPEQYKECADPALDFLVEKDQE----YCVCEMP 364 Norway rat

O13263   460 CSFKEWTLTRSLAKWPSLNSEEWMLRVLSWELGekLNKNLTKNDLGNLNIFYQDLNSRSISESPTYNIVTLLSNFGGQLG 539 African clawed frog
P55270   460 CSVTIYKLSASYSQWPSATSQDWVFQMLSRQNN--YTIKNKRDGVAKLNIFFKELNYKSNSESPSVTMVTLLSNLGSQWS 537 cattle
P37088   479 CSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNN--YTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQWS 556 human
Q92075   465 CKMTEYQLSAGYSRWPSAVSEDWVFYMLSQQNK--YNITSKRNGVAKVNIFFEEWNYKTNGESPAFTVVTLLSQLGNQWS 542 chicken
P51167   440 CLVSEYQLTAGYSKWPNRVSQDWVLHTLSRQ----YNLTD-RNGIAKLNIYFEELNYKTILESPTINMAMLLSLLGSQWS 514 African clawed frog
P51172   455 CRESAFKLSTGTSRWPSAKSAGWTLATLGEQGLp-HQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCS 533 human
AAA75459 448 CNDTQYKMTISMADWPSEASEDWIFHVLSQERDqsTNITLSRKGIVKLNIFFQEFNYRTIEESAANNIVWLLSNLGGQFG 527 human
P37090   446 CNDTQYKMTISMADWPSEASEDWILHVLSQERDqsSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNLGGQFG 525 Norway rat
CAA74979 415 CNLTRYNKELSMVKIPSKTSAKYLEKKFNKS-E-----KYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMG 488 Norway rat
P55926   365 CNLTRYGKELSMVKIPSKASAKYLAKKFNKS-E-----QYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMG 438 Norway rat

O13263   540 LWMSCSMVCGLEIVEVFFIDSFWVILRQKWHKlCNWWKNRKENEIEEIPditvpamaghnNPLCVDHPICLGEDDPPTFH 619 African clawed frog
P55270   538 LWFGSSVLSVVEMAELIIDLLVITFLMLLRRFrSRYWSPGRGGKGTQEV-----------ASTPAASLPSSFCPHPAFFS 606 cattle
P37088   557 LWFGSSVLSVVEMAELVFDLLVIMFLMLLRRFrSRYWSPGRGGRGAQEV-----------ASTLASSPPSHFCPHPMSLS 625 human
Q92075   543 LWFGSSVLSVMELAELILDFTVITFILAFRWFrSKQWH-----------------------SSPAPPPNSHDNTAFQDEA 599 chicken
P51167   515 LWFGSSVLSVVEMLELVIDFVIIGVMILLHRYyYKKANEGE----ETTV-----------VPTPAPAFADLEQQVPHIPR 579 African clawed frog
P51172   534 LWFGASVLSLLELLELLLDASALTLVLGGRRLrRAWFSWPR-----AS------------PASGASSIKPEASQMPPPAG 596 human
AAA75459 528 FWMGGSVLCLIEFGEIIIDFVWITIIKLVALA-KSLRQRRAQASYAGPPpt-------vaELVEAHTNFGFQPDTAPRSP 599 human
P37090   526 FWMGGSVLCLIEFGEIIIDFIWITVIKLVASC-KGLRRRRPQAPYTGPPpt-------vaELVEAHTNFGFQPDTTSCRP 597 Norway rat
CAA74979 489 LFIGASLLTILELFDYIYELIKEKLLD--LL--GKEEEEG-----------------------SHDENMST--------- 532 Norway rat
P55926   439 LFIGASILTVLELFDYAYEVIKHRLCRRGKC--QKEAKRS-----------------------SADKGVALSLDDVKR-- 491 Norway rat

O13263   620 SALQLPQAQDcrVPRTPPPKYNTL 643 African clawed frog
P55270   607 SSPPDPAISP--ALSAPPPAYATL 628 cattle
P37088   626 LSQPGPAPSP--ALTAPPPAYATL 647 human
Q92075   600 SGLDAPHRFTveAVVTTLPSYNSL 623 chicken
P51167   580 GDLSQRQISVv-ADITPPPAYESL 602 African clawed frog
P51172   597 GTSDDPEPSGphLPRVMLPGVLAG 620 human
AAA75459 600 NTGPYPSEQAlpIPGTPPPNYDSL 623 human
P37090   598 NAEVYPDQQTlpIPGTPPPNYDSL 621 Norway rat
CAA74979 533 ---------CdtMPNHSETISHTV 547 Norway rat
P55926   492 ------HNPCesLRGHPAGMTYAA 509 Norway rat
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