Conserved Protein Domain Family
bcl-2I13

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pfam12201: bcl-2I13 
Bcl2-interacting killer, BH3-domain containing
This is a family of pro-apoptotic Bcl-x proteins, B cell leukaemia/lymphoma 2, or BIKs. BIK proteins rely for their activity upon an intact BH3 domain lying between residues 48 and 80, as in UniProt:Q13323.
Statistics
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PSSM-Id: 432396
Aligned: 6 rows
Threshold Bit Score: 190.808
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q13323         1 MSEVRPLSRDILMETLLYEQLLEPP-TMEVLGMTDS--EEDLDPMEDFDSLEC-MEGSDALALRLACIGDEMDVSLRAPR 76  human
EHB10391       1 MSEARPVTRDLLMETLLYEPLPGPLlATGALAVMHPfrGEDLSPPGDTDLVGC-LEGSSLMALRLACIGDEMDLRLRAPR 79 
O70337         1 MSEARLMARDVI-KTVPHDQVPQPPvASETPSMKEP--------VRDVDLMEC-VEGRNQVALRLACIGDEMDLCLRSPR 70  house mouse
ELW64498       1 MSAARPLPADLLLEPHLFEQLVEILsTMEVPGMTEP--TEGLAPAEDLDLLGClMEDRDQVALRLACIGDEMDLRLRSPR 78 
XP_003783480   1 MSAGRPVSMDHFMETFPFEQLLEPL-TMEVLGMTEP------------NPMEC-LEDSDQVALRLACIGDEMDLHLRSPR 66 
XP_008978114  70 MSEVRPLSSDIFMETLLCEQFVDPL-TMEVVGGSDP--EEDLDPVE--DPLEC-MENSDALALQLACIADQMDVSLRARR 143
Q13323        77 LAQLSEVAMHSlgLAFIYDQTeDIRDVLRSFMDGFTTLKEniMRFWRSPNPGSWVSCEQVLLALLLLLALLLPL-LSGGL 155 human
EHB10391      80 LAQLPGRAVHS--LAITYSQM-GLWGVLRSLTPGLTSLRD--MWPWGHLAPHAWVSPGWACRQLLPVVLLVLLLgILRLL 154
O70337        71 LVQLPGIAIHR--LAVTYSRT-GVRGIFRSLIRSLTNLREn-IWSWRVLTPGAWVSPDQDPGQLFPMVLLVFLL-LGGAW 145 house mouse
ELW64498      79 LAQLPGMAMHSlgLAVTYNQT-GVRGVFRSLANSLGSLRQ----------IRTWVTPGQVCRQALPAMLLLLLLvLSGVL 147
XP_003783480  67 LAQLSRMTMHS--LGLSYNQT-DGQGVLRSVISGFTNLREniAGFWRSLSRGPWVCPAPAWEQVLLLLLLLVLL-LAGGL 142
XP_008978114 144 LAQLYEVAMYSpgLAFVLDRT-DIGDVLSGVVDVFANFQEdiVRLWRSLSSGSWVSRKQAV--LLALLALLLAM-FSGGL 219
Q13323       156 HLLL 159 human
EHB10391     155 LQGG 158
O70337       146 YLQL 149 house mouse
ELW64498     148 HLLL 151
XP_003783480 143 HLLL 146
XP_008978114 220 HLLL 223
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