Conserved Protein Domain Family
UEV_AKTIP
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cd23814: UEV_AKTIP 
ubiquitin E2 variant (UEV) domain of AKT-interacting protein and related proteins
AKTIP, also called Ft1, or fused toes protein homolog, is a component of the FTS/Hook/FHIP complex (FHF complex), which may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. It increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. AKTIP contains a UEV domain that is homologous to E2 ubiquitin ligases but lacks the conserved cysteine residue required for catalytic activity.
Links
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Statistics
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PSSM-Id: 467434
Aligned: 110 rows
Threshold Bit Score: 80.6724
Created: 11-Aug-2017
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9H8T0        77 YSLLAEFTLVVKqk------lpGVYVQPSYrsaLMWFGVIFIRHglyqDGVFKFTVYIPdNYPDg----dCPRLVFDi-- 144 human
OXA60706      54 SYFTAEYCLLGAiqinqpnklsGLYAIPSAqspFLWLCVLFVHNgpwqGGVFRFVLKFPdSFPDassqnnLPVVQFTgsy 133 Folsomia candida
ODV90715       8 QEIRVELANLGShn------psGVYVIANHdnlYLLDGVIFVHSgpykGGIFHFQIHLPdDYGSvd--saAPRVKFKs-h 78  Tortispora case...
SHO75761      20 QQIFIQLAHLCEpgi----mppGVYLMPDEtdpLRLCGTVFVRQgpyfPGVFRFSVQFTvQNTQl----vLPTIFFPp-- 89  Malassezia symp...
KNB42670      13 IELSKQYSELDRfrq----dlhGLYVLPREkdiFTWDGIIFVSEgiwsEGIFKFTLRISqKSNHg----sIPVVTFVt-- 82  Blastocystis sp...
ETS63699      14 RDISFQYAQLCLpsn----cpkGVYVQLDDddtHLWHGVIFVQNgpfsGGIFRFDIVFPpTYPSa-----TPQVFFPp-- 82  Pseudozyma aphi...
XP_025358089   9 TELQSQFAMLRQpgn----cpeGVYVSPSKs-lDVWDGVIFVRKgyyqGGVFRFKIQFTtSYPIr-----APLVTFSk-g 77  Meira miltonrushii
XP_006680739  64 KCLQLEYTTLRVla------psGVYILPVPeapTLWQGVVFMNEglfnGGIFRFVIEAGdTYPDt-----IPVMRFTs-- 130 Batrachochytriu...
XP_012556245  59 KLIQNELKLTFLns------qdGIHVVPSYtslQVWFGVIFVKEgpydEGIFHFSIIFQdSYPEt-----RPLLQFKs-- 125 Hydra vulgaris
XP_027483782  11 QRLMEQSARLHDpca----apdGVYVAPDEedfLRWTGVIFVRSgeyaPGVFRFSIQFSiSNGHl----sLPAVYFPp-- 80  Malassezia rest...

Q9H8T0       145 PVFHPLVDptSGELDVKRAFAk------------WRRNHn----hIWQVLMYARRVFYKID 189 human
OXA60706     134 PKCHPLINpsRGTFDIKRYYKt------------YNRSSh----hIWQLLKCTRKIFYKLE 178 Folsomia candida
ODV90715      79 IPSHPRIDa-SGDLDLTLLLSkhqtgpsiddpidWLQSKkr--iyIHTLCKFIKASFKSDL 136 Tortispora caseinolytica NRRL Y-17796
SHO75761      90 ILIHPIVEaaSGRVNMLPYLSmai-------qraWSTHPeep-mfLTCLAHYLHELFSADF 142 Malassezia sympodialis ATCC 42132
KNB42670      83 PLYHPFVNprTNCLDVQYIYPq------------WRTDEn----pLVNLLKKIVNMFQVSS 127 Blastocystis sp. subtype 4
ETS63699      83 TLLHPLVDpdTGRLLLSSRFPt-----------aWRPRQd----fVFHILQFVKDAFQEDN 128 Pseudozyma aphidis DSM 70725
XP_025358089  78 SLIHPLIDprDDHLALASGFPe------------WDSTKd----nVVKLLFYIKNIFKTFH 122 Meira miltonrushii
XP_006680739 131 LLFHPLVDplTGVLDSTEVFPs------------GNSIPm----gVVVLIQYMKRILKVDV 175 Batrachochytrium dendrobatidis JAM81
XP_012556245 126 KVFHPQIDktNGILNLKHIYKq------------RNYSNyi---pIWELLRYTRSLFYHID 171 Hydra vulgaris
XP_027483782  81 ILLHPIIEpiSGRLNLLPYLAmaq--------kyHRPIDpddptfFSSLLAFISECFTPFV 133 Malassezia restricta
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