Conserved Protein Domain Family
Ints3_N
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pfam10189: Ints3_N 
Integrator complex subunit 3 N-terminal
The Integrator complex is involved in small nuclear RNA (snRNA) U1 and U2 transcription, and in their 3'-box-dependent processing. This complex associates with the C-terminal domain of RNA polymerase II largest subunit and is recruited to the U1 and U2 snRNAs genes. This entry represents the N-terminal domain of the Integrator complex subunit 3 (Ints3), also known as SOSS complex subunit A (SOSSA). It is a component of the sensor of single-stranded DNA complex (SOSS), which associates with single-stranded DNA, important for DNA repair and efficient homologous recombination. This subunit serves as a central adaptor for SOSS complex assembly and stability, and facilitates the accumulation of the complex to the sites of DNA damage. This region acts as a scaffold for SOSSB1 and SOSSC interaction and it is not essential for ssDNA binding.
Links
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Statistics
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PSSM-Id: 431123
Aligned: 26 rows
Threshold Bit Score: 498.292
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
KJE89155      133 HAHNNVVSALCYGMLTgltlgkplpqivvgvhpplnpsESAALSELsllyLRQLRDVVRDNFIFLVSLLDR-LCGTFAHR 211 
XP_006676969   49 TDYEQVAGGLLHGILT----------------------NEIQFERY----FQLLAFVVRDGFATVIHKLKYvSETDKFKM 102 
EGT39095       56 EEHDIKSIGVMYHILTsi-------------------eNQELFQKM----LKYINGGGVDYWHTVLCNMNM-ILFECWPF 111 
CDM63509       56 EEHDVKSIGLMYHILTsg-------------------eNPDLFGKM----IRYVTGGGAEYWHHVLCNMNM-ILFEVWPF 111 
XP_003111147   57 EQHDSKSIGVMFHILTsg-------------------eNVDLYQKM----VRFINGGGVDYWHNALCNMNM-ILFECWPH 112 
EPB87097       59 KEYNEVILALLYGALT----------------------ETENARMF----FQSIASVNRDNYFALIQKLQSiLISAKFQY 112 
ERN03085       44 SEYVQLNQALAYAILT----------------------QPQLSKVH----ITHLHTIVTDGYRSFVSLLVK-LVSESYRK 96  
KRG92099       44 DQYALLNGAILHGALT----------------------EPHFSKTH----IKHLHAIVTDGYATFVNLLLD-AVLQLYPK 96  
XP_009132998   45 QESLELSRAIVYALLC----------------------DSGSSKTH----IKHLHAVVTDGYAFFTSLLVG-IVVELYGK 97  
O23315         49 QEYLELNKAIVYGVLC----------------------EPNSSKTH----IKHLHALVTDGYAFFTSLLIG-IVVELYVK 101  thale cress

KJE89155      212 LLDSVRPQVVALVDHLIVS--RVQGAENLVPLLLRQIRSGDVSASNTHFASLVLDTLIQpHLQW-VYLY--PALVSQIFY 286 
XP_006676969  103 LNRFAQKQSIWLLDKLLTTlpMTEQLSYIILRFMRQIKHGNCSKDNIAYTKFIVDFLTS-KRAI-IAKD--KVLARHVVF 178 
EGT39095      112 IHLACKEQLLRLIREAVRL--NVKQIENVLMNVYRVATVSADPPGKQRIFKKLTGMIRE-NEAWfKGQKqcTALVANILT 188 
CDM63509      112 LHLLCKEQLLRLIREAVRQ--NVKQVENVLMNAFRMSIGSSDFATKQRIFMKLNSMIRE-NEAWfKSQKacAALVANILT 188 
XP_003111147  113 IHLACKEQLIRLIREAIRQ--NVKQIENVLMNAFRVANGSFDNVSKQRMFARLSAIVRE-NDVWfKSQRtaAALVGSIII 189 
EPB87097      113 LRSPVRDQVFWLISELTNL--GAQHVDSLYLILMRQIKCGDASQFNTTLCDHILRLFEL-HKSW-LETN--PRVIPFAVY 186 
ERN03085       97 LFESARAQLIWVFGKLIEV--EALGVENLLVSLLRQIISGDFSHESLWLSMELLKVLNQ-NWGWvLRKQ---NSMTSALF 170 
KRG92099       97 LLHSAKTQLLWLTEEMVHV--LAIGYDAVLVSLLRQIGAADCTEGNLNLCSELVTLFLK-QFDRlLEDA--PHVLSSALY 171 
XP_009132998   98 LVDSAKVQLLWLTKEMVDA--SSVGLEDLLVSLLRRIGSGDYGEQNVWLCSELVSLFLD-KWDClLEDA--PLVLTSALY 172 
O23315        102 LVDSAKIQLIWVTKEMIDV--SSVGIEDLVVSLLRRIG---------------ISLFLE-KWEClLDDS--PLVLTSALY 161  thale cress

KJE89155      287 TYLRLIADHArv------------apQLDRLRQRETEFCLTLWRERFVDCSAIGRDVLRALQLVGNLPEFASLWTDLIHR 354 
XP_006676969  179 MLVRAIADHL----------------HHLDLRTKEMALFFSLISSNIQDCVYIGRDFIRSLMEISKIPSIAKLLLSIMQS 242 
EGT39095      189 CTASVIASSPap------------mtAQDTFRETLIDFVHFVIKNKKTDCQTLGRDFILVLMRLGKLPQIEDIWKDIATN 256 
CDM63509      189 CTTSVIISSPap------------isSQDTFRESQLDLVQWVIKSRKIDCLTLGRDFILILIRLGKMPQIEEIWKDIVAN 256 
XP_003111147  190 CTSSVISYTPap------------itSQDTFRESLTDFVCWVIRNKKMDCLTLGRDFVLVLIRLAKLPQIEEIWKDILTN 257 
EPB87097      187 TFLRAIADHRt--------------sQLQPLQQKEIRFVHMLMREKWMHCVPIGRDLIRVLKELSTIPEFSQIWDDVVNH 252 
ERN03085      171 TYLRLLADHYkfp-----------npNLVVLKMMEIGFCIRVLRESFHSCMGIGRDLIRLLQDLVLIPEFRDLWKDLISN 239 
KRG92099      172 AFLRILSDQFrvcvekletlkrldieKLETLKRREIHLCVKIVREEFHLCLKIGRDFIRLLQDLAHVPEFKALLQDIVFN 251 
XP_009132998  173 SFLRLLADHCrvt----------gipKLENVKRLEIKFCVKMFREQLHLSLKIGRDLVRLLQDLVHISEFKEIWNDLVCS 242 
O23315        162 SFLRLLADHYrvl----------gvvKLENVKRLEIKFCVKMFREQLHLSLKIGRDLILLLQDLSHVSEFREIWNDLVSN 231  thale cress

KJE89155      355 PTTL-NAHFPGVKQILRTDTRARFLV-GRTTLDLESKLRFLLTTVKHGELRRYYQWFAKKYLeAPESEAMLPDLIRYVCC 432 
XP_006676969  243 PSPE-YPNIPSLSDFLDRPTPREFLI-SRLTPDMEIRIVFILNSVPKRLSFTFIEQFRKRFL-TLESETLLPDIIRYICG 319 
EGT39095      257 PASY------GVAGIEDFLSKPHVLQhLRLSIELDRKLQFMVNN-GGKNMLIYFSWFSNKYLrGADGPALRAECVRQLLY 329 
CDM63509      257 PASF------GVSNLEEYMTKQNVLQhVRISIELERKVQFMVVN-GGKNLLTYFTWLNNKFFrANDGPALRAECVRYVLS 329 
XP_003111147  258 PASY------GVASIEDYWGKNHYLQhVRISIELERKIIFMIHS-GGKNLLIYFSWFANKYFrGNDGPALRAECVRHVLY 330 
EPB87097      253 PQKL-SPKFGGIQTMLNSPTPRDFLK-CRLTPDIEHKLLFILQNLRITHFQKNLNWFTQRFLsAPESEPFYVDVVRYLVA 330 
ERN03085      240 PSAFnVPEFSDISQIYCLKTPNRYFL-LRITPEMETQLRFMLSHVKWGNQIRYQEWFASKFLsKPNRESLICDIIRFICC 318 
KRG92099      252 PSVFnVVGFKDVSQIYCTRTSSRYSL-LRISPEMETQLRFWLTDIKLGHHRRHQLWFANKFLnERDKEFLIVDIVRFICC 330 
XP_009132998  243 ----------DVSKIYQLKTSSRYFL-LRITPEMETQLRFLLGNVKLGSHKRHQIWFLKKFLlGPEKETVLIDIVRFICC 311 
O23315        232 ----------HCSEIYQLKTSSRYFL-LRITPEMETQLRFLLGNVKLGSHKRHQIWFLKKFLlGPEKETLLIDIVRFVCC 300  thale cress

KJE89155      433 AYHPTNEVLASDVAPRWMTISWLMWRAKSP-TAMADVRLALFYDWMFFDPAR-SNIMNIEPGILLIQHML---------- 500 
XP_006676969  320 AIHPNNAILASDIVQRWHLISILLRGIKAP-ACAQSCKLSLYFDWLFFNHAS-DSVMSLEPGILVMVKNL---------- 387 
EGT39095      330 MAPDQKQ--PGSYDNRIQIIHLLVTTAQPV-AEQQWLKLCLFADWFGCDEKNiTNFGYVETPFLVLRYALflptmpshpn 406 
CDM63509      330 MNLDPAKALPNAQENRVQLLHLLISTVPSG-PELQWLKLCLFADWFGCDDKNsANLMCVENSFSVVRYALfltptgpqqn 408 
XP_003111147  331 LQLDVAKAPPSAFENRIQLLHLIVSTAPSG-PEQQWLKLCLFADWFGCDERNpSNFTYVEIPLSVVRYALflspspphqn 409 
EPB87097      331 GWYPSNQILQSDIVPRYVVIGSMIRSIKSN-IVAANVRTALIFDWLFFKPT--DNIMFIEPAMLLMERSA---------- 397 
ERN03085      319 AHHPPNEVIQSNVISRWAISGWLLKCCKKF-HVEANAKLALFYDWFFFDEQF-DNIMNIEPAMLLMLNSI---------- 386 
KRG92099      331 AHHPPNEIIQSDIFPRWALIGWLLTCCRKK-HVEESVKLALFYDWLFFDERM-DSIMNIEPAILLMVHSV---------- 398 
XP_009132998  312 VVHPTNEIIRSEIMPRWAVIGWFLDLCKQNhHVEGRVKLALFYDWLFFDERI-DSIMNVEPAVLLMLWSI---------- 380 
O23315        301 VIHPTNEIIRSEIMPRWAIIGWLLELCRQNhHIERSVMLALFYDWLFFDERI-DNIMNVEPAALLMVWSI---------- 369  thale cress

KJE89155      501 -----NMNGTFAASLLEFVCLIATEFVPSL-SSSITTSLRAAFYTCVSKRVIPSLSAIVNHTSIDEPLRDKFNT 568 
XP_006676969  388 -----QTSPAISATMLEFLALIADRFLPTL-SAHIYHNLKLSMSIVVEKRVITSLSLILLSPQLDEFTKETVTK 455 
EGT39095      407 tivqnSHGAQFANSLFEYICKSVDVFIPHL-SGYVRKNVNNAMRCC-RDRLPHIFPQVMENTKIDRKIVDLLKT 478 
CDM63509      409 sivqgSHCSQFANSLLEFLCKSVDVLLPPAyAEPIRRNVNSAMRFI-KDRLQHNLPQILENSKIDRKVSELLRN 481 
XP_003111147  410 sivqsSHCSHFANSLLEYLCKSVDVLFPSN-VEYIRKNVNNAMRYC-RDRLQHNLAQILENSKIDRKVTELLRS 481 
EPB87097      398 -----ERYAHITASLMQFLKRSVDEYFPPM-KDYMSQCVACGMRVMLSKGVIRSLLPIYRCPATDQVTRDYMQA 465 
ERN03085      387 -----HMHIDVTQTLLDFLFLVMDNYDVNR-KEIIAQGIYTSLHALVRRGVVHSLEPLLSSSRISPMLREKLKN 454 
KRG92099      399 -----PKFINMTHALLEFLLHLVDRYDVGR-RSVIVKGVSSAFQLLVRKGVVRSLNVLTSCSALNPGLREGLKR 466 
XP_009132998  381 -----PQYPHITHSLLEFLLHLVDTYDIAC-RDMIMRGVASAFREIERKGVVQSLDMFLSNPEIATDLKKKLAN 448 
O23315        370 -----PQYPHITHSLLEFLLHLVETYDITR-RDTIVRGLTSAFREIERKGVIRSLDIFLANPALAPDLKKKLAN 437  thale cress
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