Conserved Protein Domain Family
RRN3

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pfam05327: RRN3 
RNA polymerase I specific transcription initiation factor RRN3
This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.
Statistics
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PSSM-Id: 461623
Aligned: 99 rows
Threshold Bit Score: 365.008
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKM79897      41 KDMYLAFVNNALQQKLNGISEPFNELVSQFNPRRrttETSSLETSTSLRTWILALTHVVSRL-ERTHSSLVEAVINT-PW 118
Q8L643        27 DTQLVQTVRKALTSVKTGDSDLYSEMVGVMARDIk--EFKDPDVVAQLETVLKALSGAVACIdVLHHQKLLSALFRMkLW 104 thale cress
P48322        54 AAVLYRKICNALETFEQ--------------------WESEAPKIQLLDQFLNIADAM-----EARTETLVKRLLSL-RW 107 Caenorhabditis ...
CAP24486      52 AAVLYRKICNALETFEQ--------------------WELEAPKLQILEQFLGCADVM-----EARTDDLVKRLLAL-RW 105
EGT45813      57 MGVLYRKICNALETFEQ--------------------WESELPKIQLLEQFIGHADTM-----ETRTNVLVTRLLAL-RW 110
XP_001966905  37 EKGLAESVRVASEEQ---NFHLVHEFTYFLREAE--------LDDDELEEILKEARKIVHNL-TPDFVNVVEALLSL-NW 103
Q9V9M6        40 EKGLAESVRVALEER---NFHLVKEFTYFLREAE--------LSDDEVVIIIKDAKRIVHNL-TPEFVTVVEALLSL-NW 106 fruit fly
XP_002051281  40 EKGIVESVRVALEEN---NFHLIQEFTYFLCEAD--------LSDDEVVQIMKDARKIVHSL-TPEFANLVEALLSL-NW 106
XP_002064674  40 EKGLKESIRVALEEH---DYHLVQEFSYFLCEAD--------LSDEEVIQIMNDARKICHSL-TSNFAGVVEALLSV-NW 106
XP_001870906  41 DLAVEAVLQDALQNG---QLQRFEVLVLEIKAEQ--------FDDDKFQQVIVESKRCVHLL-NANFGMLVEALLSV-NW 107
EKM79897     119 TTLDSATVKSYIIFIGMLLSARPGYLSLVLSRVAQGFTYQSgiQTLsQAFPEs----sSSPITRRVIYDRLHYLLQHLLS 194
Q8L643       105 DHRPD-VMDALVNLVISLAVTSGKYLDSCLNMLVSNFVPPP--------WVVnnlshsRILNKKIDVLSRVHAALLKISI 175 thale cress
P48322       108 DKIPGSVIERFRNFLCELAIRHLCFTEEVYSAVVERLVPQIs-----VTEETgvvtliLTEKVQNEHFEMAHHIISSVLR 182 Caenorhabditis ...
CAP24486     106 DKIPQSAIERFRTFLCELAIRHLCFTEHVYTAVVQRLVPQVs-----SDESTgivsfvLTEEKQNEHFEMAHIILSSVIR 180
EGT45813     111 DKIPSSIIGKFRTFVCELAIRHLCFTEDVYLSVIQKLVPQYe-----ANQETgivkmvLTEEKQNEVYEMAHYIISSVLR 185
XP_001966905 104 RKRSCKTIEAFTEFSIEILVAHNRYLPMGISKFILHWIPNDq-DAAdW-VNG------CPSNQIYCELKPIHDVINRIIT 175
Q9V9M6       107 KKRSSEIIEAYTEFCIELMVTHNRYLPIGVSKLIVHWIPGDm-DESdW-VHG------CPSEHVRNELKPIHKVLDRILT 178 fruit fly
XP_002051281 107 KKYSSDAIQAYTEFSVDVMIAHNSYIHIGIGKLILNWIPNDq-ESAeW-LNG------CPSERVRAELETVHSLLNRILT 178
XP_002064674 107 RKRSSEAIEAYTEFAIDIMVAHSTYIPIGISKFIVHWVPTEn-ESSeWQIHG------CPSEIVRNDLETVHKILDRILT 179
XP_001870906 108 LARNESSREVYKGFVIELLVAQGNYTTLAVSKLVQLFLPRD--EDKeGWVRG------VPTVATAERFEPVHDLFVRLKN 179
EKM79897     195 LIPTLPSTLQPLLAQNFPHKRQNQLTQSTYIRNLLRISS--YCP-ELSERILATIVDRALQIDV-----E---------- 256
Q8L643       176 LVPLTPSRLVPMLFQQMPKMHKKDHSIVIYVESLLKLENssIGQ-VGGSMILGMVMERLRDLDLeiewdD---------- 244 thale cress
P48322       183 CFPLSARALLKCVKRVMPHFTRPSVTVAGYMRNLILMQK--YIPaSISKDVWEAVFERLAKDDThnwkcEqneemskspr 260 Caenorhabditis ...
CAP24486     181 CFPLSAKSLLKCLRKAMPHFTQPPVAVSGYMRNLMLMQK--YVPlSITKDVWETIFERLAKDDAhnwrcEqneeeskspr 258
EGT45813     186 CFPLSAKTVLKCAKRAMPHFTCPAVAVGGFMRNLMLMQK--YIPaSIAKDVWETIFERLARDDAhnwrcEqneednkspr 263
XP_001966905 176 AVPMAFDVIVDTISSKFPYFKKPAHVTAGYLFNLLWLLD--YKP-VFEEIILQLVLQKLLILDVnaprdE---------- 242
Q9V9M6       179 AVPMAFDIIIDAISAKFPYFKKPYHVTAGYLYNVLWLLE--YKP-IFEELVFQLVLQKLLLLDVnapkdE---------- 245 fruit fly
XP_002051281 179 AVPMSFDVVIDTIASKFPYFKKPAHVTAGYLHNVLWLME--YKP-VFEELLVQLVLQKLLVLDVnaprdE---------- 245
XP_002064674 180 AVPMSFDVVIDAISAKFPYFKKPSYVTAGYLYNILRLLE--YKP-VFEELVMQLVLQKLLILDVnaprdE---------- 246
XP_001870906 180 VIPMIFDVILVQLRKQFPYFKRATHVVCGYVYNTLRMTD--HSA-MFTEELLDIIFYRLVAIDVntprnE---------- 246
EKM79897     257 ---------IQ----------VEIE-ELEEEETLEEQplfeldpfdvvvgqegpetsdlsdiddsdedVGDDFSDLSSEA 316
Q8L643       245 ---------IPqddssrgmfdMELE-DAAEGTMndgdelpv--------------------------------------- 275 thale cress
P48322       261 lfalnddilIE----------EVVEgNTNDSEDV-TPeql---------------------------------------- 289 Caenorhabditis ...
CAP24486     259 lfalnddilIE----------DVIE-TTNDSEDV-TPkll---------------------------------------- 286
EGT45813     264 lfalneeilIE----------DVVE-STNSSEDVTTPevl---------------------------------------- 292
XP_001966905 243 ---------ID----------L----ENHGEEkqm-------------------------------edPLFQIDEIAALT 268
Q9V9M6       246 ---------IE----------L----EMNDEEekv------------------------------eadTLFEIDDVCA-E 271 fruit fly
XP_002051281 246 ---------IE----------ALKE-DTDDEDdkm------------------------------eeqAIFQMDDI---- 271
XP_002064674 247 ---------ID----------V----ETDDEEDDDEDrepdk----------------------mdedGIFQMDDIPT-- 279
XP_001870906 247 ---------IE-------------DaEFPDEADDG---------------------------------QIFAMEETPVIE 271
EKM79897     317 GLEEElapevltnmRHIQEMVQKLDSILTLVFDHFKRtsafppnnsagsgrmtaynasrppsppelltlpplpsfsdcav 396
Q8L643       276 -------gplkqdtSDGSIVSKLLDKLMVVAFEHLES------------------------------------------- 305 thale cress
P48322       290 ------------eqRKGEQMIQYLDSVCTDVITFIRS------------------------------------------- 314 Caenorhabditis ...
CAP24486     287 ------------eqRKGEQTMQYLDAVCTDVIAFIRH------------------------------------------- 311
EGT45813     293 ------------eqRKGEQTLQYLDSVCTDLITFIQD------------------------------------------- 317
XP_001966905 269 DANKSeel-------vdHPIGQSLDICLHMLYKFFDK------------------------------------------- 298
Q9V9M6       272 NVPKSeks-------vsHPVGKTLDVCLFLLYKFFDG------------------------------------------- 301 fruit fly
XP_002051281 272 --NAPpkpp----qsleHPIGHMLDICLLKLFKFLDE------------------------------------------- 302
XP_002064674 280 --KSPspla----ktidHPIGQTLDICLAMLYKFLDT------------------------------------------- 310
XP_001870906 272 IDDDE---------TMKLPLAETLDCCLETMFRYIEE------------------------------------------- 299
EKM79897     397 tsplmptstppfldgrtefaptpepstfpPPSTSSsQNHDPMSIMR------------------------IQFNALLSIF 452
Q8L643       306 --------------------------------------CQNDGRLD------------------------QVFESLFKSF 323 thale cress
P48322       315 ----------------------------------SvDSEIDEENGNertklndkwlrnfkitgdkvlpkeKLFDTFLECL 360 Caenorhabditis ...
CAP24486     312 --------------------------------SEGvDAQENEEKGQkieekwlrtfk---ikgdkvlapeNLFDTFLEVL 356
EGT45813     318 ------------------------------------------AEGIseenahqkwlksfkihgdhvmapeKLFDTFLEVL 355
XP_001966905 299 -----------------------------KCNIKPnCTDQQRCAAN------------------------RIFNILLFTF 325
Q9V9M6       302 -----------------------------KCRLNEnSSEEQRRTAN------------------------RLFKMLLYLF 328 fruit fly
XP_002051281 303 -----------------------------KCRPKPdCTDDQRIAKS------------------------RFFKTLVHIF 329
XP_002064674 311 -----------------------------KCRLAPtTNEEQRWTAN------------------------RFFKMLLFIF 337
XP_001870906 300 -------------------------------------RARIEGGSD------------------------RVYGLLLKLF 318
EKM79897     453 DRVILRTFKSRYTQFLIFWYTSLD-PEFADIFQGMLVERALLGTSatttqlqsefqegeggpsndasgahgSTVARAA-- 529
Q8L643       324 ENFILNTYKSKFTQFLIFYACSLDpENCGVKFASKLVEIFLSSNK--------------------------HVATRMS-- 375 thale cress
P48322       361 ESTMLNATHVQYVSFIWLYFCSLS-QEYEKKMLEHLWQVTIRMPRa-------------------------PADARKSqg 414 Caenorhabditis ...
CAP24486     357 ESTMLNATHVQYVSFIWLYFGSLK-EEYEQKVLEHLWQVTIRMPRa-------------------------PADSKKSqg 410
EGT45813     356 ESTMLNATHTQYVSFIWLYFGSLK-SEYEMKVLEHLWAITIRMPRa-------------------------PADARKSqg 409
XP_001966905 326 DEILLPSHNTHHVQFVIFFITSLR-QTYSEAFLSSLWQKVQNPNV--------------------------SAIIRHG-- 376
Q9V9M6       329 DEVLLPSHNTHHVQFILFYATSLR-SVYSEAFLDSLWTKVQNPNV--------------------------SAVIRHA-- 379 fruit fly
XP_002051281 330 EEVLLPSHNTHHVQFVIFYACSIR-PAYTEIFLSALWHKVQNPNV--------------------------SSIIRHA-- 380
XP_002064674 338 DEVLLPSHNTCHVQFVIFQVCSLR-PAYAEAFLSSLWLKVQNPNV--------------------------SSIIRHA-- 388
XP_001870906 319 DKHILPTHNTHHVQFLMFYCCSFD-QSYGERFIEHLLKMVRNPNI--------------------------STPTRQA-- 369
EKM79897     530 AASYIGSFVSRALFVDGESTRRVVALLCEFLMAHLDDVEES-M-RAQTSTlniggpQHTVFYAVSQAVFLIFCFRWRDLL 607
Q8L643       376 AVAYLASFLARGKFLPVSFVASMLKRLIDECVGYCRTCNDDtr-----------peAHQIFFSGCQAIMYVLCFRMRSIL 444 thale cress
P48322       415 AASYLAAFLARAKYVKKSTAFTWLEEVYIWLRHYVDQFGSGsSqILPGLQ------RHGTFYSVSQAFFLVFAFRYKEFV 488 Caenorhabditis ...
CAP24486     411 AAAYLAAFLARAKYVKKDVAFTWLEEIYTWLKRYVVQFGSGsSqILPGLH------RHGTFYAISQAFFLVFSFRYKEFA 484
EGT45813     410 AAAYLAAFLARAKYVKKSTAFTWLEEIYTWLRHYVDQFGSGsSqILPGLQ------RHGTFYSISQAFFLVFAFRYKEFV 483
XP_001966905 377 AIGYLASFLARAKFVPLCTLTLYLMELSKWAHSYIDDSDEY-S-QNCSLK------SNLVFFSVCQAIFYLIAFRVRDLT 448
Q9V9M6       380 AVGYMASFLSRARFLPLSTVTFYLKELTRWAHTYIDDSDAY-K-QNCSLK------ANLVFYSVCQAVFYLIAFRAKDLT 451 fruit fly
XP_002051281 381 AVSYIASFLARAKFVPLGTITYYLKELSNWANNYINDSDEFsS-KNCSLK------ANMVFFSVCQAIFYLIAFRARDLT 453
XP_002064674 389 AVSYMASFMARSKFLPLSTIKFYLTELSKWSLRYIDDTDEYnS-QNGSLK------ANMVFFSVCQALFYLIAFRAKDLT 461
XP_001870906 370 AVGYVASLLARAKYVPMPLLKKTLQDFSDWVHGYLNRSDSL---HNQSLK------AHLVFYSVCQAIFYVVAFRSKQLT 440
EKM79897     608 DLEEedgefnvvgattdmrqnegtrgeRPRKWMPELaILQRVVNSVLNPLRVCSSNVVMQFARVAQATDFIYCYTI---- 683
Q8L643       445 D--------------------------VPRFRSQLT-PLESILMHKLNPLMVCLPSVVAEFLRQAKEGGLFIVSDSfifd 497 thale cress
P48322       489 KNKDml--------------------eTIRRW-----GVGRVVHSPLEPLKYVSKPVARCFSAITRSLQLVYCNHIi--- 540 Caenorhabditis ...
CAP24486     485 KNQEil--------------------eAMRRW-----GVGRIVHSPLEPLRYVSKPVARCFSAITRSLQLVYCNHVi--- 536
EGT45813     484 KDQEml--------------------eKIRGW-----GVGRVVHSPLEPLRYVSKPVARCFSAITRSLQLVYCNHVi--- 535
XP_001966905 449 ATT------------------------KDLLFLQSL-QLSRLAMCHFNPLRYCLAAIATAFAGVTRTYQLAYCHTV---- 499
Q9V9M6       452 ASS------------------------KDLLFLQSL-QLSRLAMCHLNPLRYCLAPVATAFAGVTRTYQLAYCHTV---- 502 fruit fly
XP_002051281 454 INQ------------------------KNLALLNTL-QLSRLAMCHFNPLRYCLPPVATAFAGVTRTHQLAYCHTV---- 504
XP_002064674 462 AGT------------------------KELLFLQSL-QLSRLAMCHLNPLRYCLPPVATAFAGITRTHQLAYCHTV---- 512
XP_001870906 441 ATP------------------------KNLAFLQTL-QLTSIANCLLNPLRVCVPGVATAFVAVARAHQIAYCNTI---- 491
EKM79897     684 --LESNKRLeyastprdpsatslainqpaepqsrtplalkifEPGSVIAELNTFFPFDPYRLPRSSSVIKDVYREWSSVA 761
Q8L643       498 dlLESELSRafg----------------------------------gfeRLDTFFPFDPCLLKSSNSFISPNFIYWSMVK 543 thale cress
P48322       541 -pIEEVQR-----------------------------------------PFDDMFPFDCYHLKESSKFMTPLMRKFSPLA 578 Caenorhabditis ...
CAP24486     537 -pIEDVQR-----------------------------------------PFEDMFPFDGFHLKVSSQFITPLMRKFSPLA 574
EGT45813     536 -pIEEVQR-----------------------------------------PFDDMFPFDGFHLKVSSQFIIPLMRKFSPLA 573
XP_001966905 500 --LERNARRklat-------------------------vyghEKCMPEETLETFFPFDPYMLKMSNKYIEINYLIYQGNT 552
Q9V9M6       503 --LERNARRklat-------------------------vyghEKCMPDETLESFFPFDPYVLKLSKKYIETNYMVYQSND 555 fruit fly
XP_002051281 505 --LERNARRklat-------------------------iyghDKLMPEETLETFFPFDPYILPLSNKFIEPSYLVYKVHE 557
XP_002064674 513 --LERNARRklat-------------------------vyghDKAMPEETLETFFPFDPYLLKLSNKYIEPHYLVYKAHD 565
XP_001870906 492 --MERNERRrtfi-------------------------lfnnGALAPDDCLDTFFPFDPYLLKKSGKRIEPIFLQYQSCE 544
EKM79897     762 I 762
Q8L643       544 A 544 thale cress
P48322       579 E 579 Caenorhabditis elegans
CAP24486     575 E 575
EGT45813     574 E 574
XP_001966905 553 d 553
Q9V9M6       556 T 556 fruit fly
XP_002051281 558 l 558
XP_002064674 566 L 566
XP_001870906 545 A 545
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