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Conserved Protein Domain Family
Synuclein

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pfam01387: Synuclein 
Synuclein
There are three types of synucleins in humans, these are called alpha, beta and gamma. Alpha synuclein has been found mutated in families with autosomal dominant Parkinson's disease. A peptide of alpha synuclein has also been found in amyloid plaques in Alzheimer's patients.
Statistics
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PSSM-Id: 460186
Aligned: 13 rows
Threshold Bit Score: 135.446
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6LRQ_A         1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGvvhgVTTVAEKTKEQVTNVGGAVVTGVTAVAQK 80 
XP_011602812   1 MDAFMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMFVGTKTKDG----VTVVAGKTVSGVSQVGGAMVTGVTAVAQK 76 
XP_003455005   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VTTVAGKTVSGVSQVGEAVVTGVTAVAQK 76 
XP_005812724   1 MDALMKGFSKAKDGVVAAAEKTKQGVTGAAEMTKDGVMYVGTKTKDG----VSTVAEKTVSGVSHVGGAVVTGVTAVAQK 76 
XP_007478272   1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGTKTKEGvvqsVTSVAEKTKEQANLVSDVMVASVNTVANK 80 
XP_003994186   1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENvvqsVTSVAEKTKEQANAVSEAVVTSVNTVAIK 80 
O76070         1 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENvvqsVTSVAEKTKEQANAVSEAVVSSVNTVATK 80  human
XP_008112683   1 MDVFKKGFSIAKEGVVAAAEKTKQGVTEAAEKTKEGVMYVGAKTKEGvvqsVTSVAEKTKEQANLVGESVVASVNTVAKQ 80 
XP_015203361   1 MDVLKKGFSIAKEGVVAAAEKTKQGVEEAAAKTKEGVMYVGTKTKEGvvhsVNTVAQKTTEQANIVGETVVGSANQVSAK 80 
XP_012321796   1 MDVFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSKTREGvvqgVASVAEKTKEQASHLGGAVFS-------- 72 
1_pfamImport   1 MDMFMKGLSMAKEGVVAAAEKTKQGVTEAAEKTKEGVLYVGSEIRSK---------DRARGSGSVVRDQSNESTEGITMG 71 
XP_008991227   1 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGvvhgVTTVAEKTKEQVTNVGGAVVTGVTAVAQK 80 
XP_031173412   1 MDAFMKGFSKARDGVVAAAEKTKQGVTGAAEMTKDGVMFVGSKTKDG----VTT----AVSGVSHVGGAMVTGVTAVAHK 72  pikeperch
6LRQ_A        81 TVEGAGSIAAATG--FVKKDql----gKNEEGAPQEG-ILEDMPvDPDNEAYEMPSEE 131
XP_011602812  77 TVESAGSIAAATG--LVKKE-------PGKQGDDAAT-AENMAEsPDVTDPAEATEED 124
XP_003455005  77 TVEGAGTIAAATG--LVKKD-------PAKQSDDASA-VQDVAEsPVDTDPADVTEED 124
XP_005812724  77 TVEGAGNIAAATG--LVKKD-------PAKQGEDVSA-VPDAVEsPIDTDSTEPTEED 124
XP_007478272  81 TVEEAENIVVTSG--IVRKEdlv-npaQPEHGAP-------------EEQPAEAAEVT 122
XP_003994186  81 TVEEAENIAITSG--VIRKEdle-qpaPSQEDKAa----------KAEEEVAEEAKSG 125
O76070        81 TVEEAENIAVTSG--VVRKEdlr-psaPQQEGEAs----------KEKEEVAEEAQSg 125 human
XP_008112683  81 TVEGAETVVSSTG--VVKMEdlh-peqPEEPLAD-----------AEEDAPVEATETS 124
XP_015203361  81 TVEGVENVVASTG--VVNPDda----vNQEDFSR-----------PPEGTVEQATDAV 121
XP_012321796  73 ---GAGNIAAATG--LVKREefptdlkPEEVAQEAAEePLIEPLmEPEGESYEDPPQV 125
1_pfamImport  72 GIRGDDGSSVGVGrvLVKSSqww-hgiPEEVGQEVGEePMAEPLlDTEGESYEEPPQE 128
XP_008991227  81 TVEGAGNIAAATG--FVKKDhl----gKSEEGAPQEGiLEDMPV-DPDNEAYEMPSEE 131
XP_031173412  73 TVEGAGNIAAATG--LVKKD-------PTKQSDEASA-VQDMAEsPVDTDPadatedd 120 pikeperch
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