Conserved Protein Domain Family
DUF4174

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pfam13778: DUF4174 
Domain of unknown function (DUF4174)
This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.
Statistics
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PSSM-Id: 463980
Aligned: 66 rows
Threshold Bit Score: 79.6008
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012812375         618 FLANFEGKRRLLLMTAPKEENKMYSQQRDEYL--ETVCEMAVRKISIVTI-------FGPLTNSTmkidhfqldnekpmk 688 
tigr:ACP_3463         39 NLAEMKNCWRPLLVFSPSDTDARLKQQEQMLD--ADADDMMDRFVLFTPI-------VPRAKQVPtplda---------- 99  
WP_014786962          26 LLADLHHLARPVLIFG-SAGDARVNEQYSALK--DHAAESNDRQMHVILLcdtplpqFQDGGAKPems------------ 90   Terrig...
jgi:Caka_0125         42 PLEAFQWTHRLILVNDETMTRNRWSASFK-----AAEAGLQERHICWFV--------LGQGRVWTnle------------ 96  
PRJNA234054:Hsw_3199  43 TLKASKWQKRVLLLCAPNADNADLRRQQQLLA--PVRAELNTRDLLVREV-------FTSQL------------------ 95  
jgi:Mrad2831_3735     25 PLDGYRDRARVLVLSAPEAGDAQLRAQRAALA--SVRAGVAERDLVVLEA-------VGS-------------------- 75  
CCH00829              33 ILDEKKDHRRVVLLYGRDINQGHLIEQQQALT--AAPDGLAERDLDVIVL-------INSEL------------------ 85  
Q88K95                36 PLAKELGKARPLVVIAPSSADPTLRGLNKALEdpATQAAFKERNLVLYSV-------ANMMGKREdk------------- 95   Pseudo...
jgi:Aave_3971         35 PLTAERWQTRPVVVVVPRENDPLLAKVRAALRepAMREGFRERDMALFTV-------VDGQGSRNge------------- 94  
WP_013793080          22 PLEAERWKTRPLIVLAASADDPLLARVQAALQepANREAFVERDMVLYTV-------IGQQGQRNgq------------- 81   Pseudo...
XP_012812375         689 vigeddllDVDLITELRKEYGM-TYND-FFMVLTDLDMRVK---QYYEVPI-SMKSVFDLVDTFQSRIKE 752 
tigr:ACP_3463        100 ---pwtllAENQMQAVREKFHV-PVNR-FEVMLLGEDGKPK---LVRDVPI-ATGELNALIDTMPRRKLE 160 
WP_014786962          91 ------vaTLAEQQALRKRFHV-APEA-FAVILVGKDGGEK---LRSDRPV-TWERLQSTIDAMPMRQQE 148  Terriglobus roseus
jgi:Caka_0125         97 -----qplPEDFAQTVRSKLFK-GRET-TEVVLIGKDGRV----KSRDGQL-DLEKLFDRIDAMPMRRAE 154 
PRJNA234054:Hsw_3199  96 --------PPADQRYAREQLKV-PANG-FVVILIGKDGGVK---RRETSPL-PPAQLFSTIDAMPMRQQE 151 
jgi:Mrad2831_3735     76 ---------GAEARTLRERLGL-PADS-FRAVLIGKDGGAK---ITAAAPI-APQRLFATIDAMPMRRTE 130 
CCH00829              86 --------MEPDRQFLMHTYHEfVPSDdFAGYLIGKDGLLK---KKFTKPI-AADELFKTIDAMPMRKDE 143 
Q88K95                96 ------nlEQQTTMALIRELKL-GASKgTKVILVGKDGERHmlkDDDTGEAiDPQVILKAVDDLPASEKA 158  Pseudomonas puti...
jgi:Aave_3971         95 ------plGTARTAALLKALDV-DARGpATFILVGKDGGVK---MKEGADV-DLQAVFAEIDRMPMRQRR 153 
WP_013793080          82 ------plEAIATKRLLLALDA-GNAR-PQVILVGKDGGKK---IQQGADA-DLQAIFRTIDRMPMRQNE 139  Pseudomonas
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