7MQ8


Conserved Protein Domain Family
Mpp10

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pfam04006: Mpp10 
Mpp10 protein
This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites.
Statistics
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PSSM-Id: 461128
Aligned: 49 rows
Threshold Bit Score: 324.225
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7MQ8_NA       25 PECFLTI----QEGLASKFTSLTKVLYDFNKILENGR-IHGS-PLQKLVIENFDDEQIWQQLELQNEPILQYFQNA-V-- 95 
Q6CRE2        12 PVGLLSQ----DALESKEPLSAVKTYFDEVINLNKNNgNSKT-TLDEIVVDGLDANQVWWQSKIILDNVQGDIMEKi--- 83  Kluyveromyces l...
CCE92651      12 PVEIL-------SQDSSSALQLVKSYLDEVITHAKKDdISTD--IDEITVDGLDANQVWWQAKMVLDRVQGDLMERi--- 79 
XP_002551917  12 PISIISE----NEDTSTDSLRLVKTYIDDVILSQKALdGKVL--LDEIVVEGLDANQIWQQVRLVLENSGPKLMGKi--- 82 
CCE82181      13 PQNVFSLfpseSNQNENYFNKLTKEFLDPLSKDHSI--------LEQIHIDGLDSTQVFGQAKIVLDNVADQLLFSdI-- 82 
EMG50041      13 PQDVFKL----KEKNNNYFNSLAKSFIDPLAKQYSV--------LDEIYIDGLDSIQVYGQTKMVLDGVGEQLLGEkI-- 78 
XP_002839842  17 QHEFLQP----KSSLHSAALVLAKKYLDPLAASVAGGkKSEV--LEKIYLDGFDVDQVWEQARLVVDAVESGVGEGkgvs 90 
XP_002173877  11 PTSFLFP----DESQG-------ASFLDECINAFSSVsVPKKcPIQQIHTKGCDAWQIYNQLALATKYALDELp------ 73 
EPY51748      11 PTSFLFP----NEQAS-------NQLVEEAIRYFSAVkVPSSsPIQKVVTKNLDAWQVYNQLAIAAKHTLDDLPDL---- 75 
O13910         9 PTLFLFP----NKEDS-------KQLVEKAIEVFSNIkIPSTsPIQTIVTKGLDNWQIYNQLALAAKYALDDLPQV---- 73  Schizosaccharom...
7MQ8_NA       96 ---------SETINDEdISLLPESEE-QE----REEDGSEIEADDKE--------------------------------- 128
Q6CRE2        84 ----------AELKVDnENDMSEESSg------DEDDASNVENSNEMsadeapvsee-------------------saie 128 Kluyveromyces l...
CCE92651      80 ----------------qELKIMTDSVdEAvpspEGEDGSEYESEEEVseggemlppnfeetvsdne-aeeleesdaqyds 142
XP_002551917  83 ----------STIRTSlA---------------EVNESDEEISSSESseveenkeeelegmnefdsdesekvdaiittgq 137
CCE82181      83 ---------PKHVSHKgEDDINVKQYdEV----DSEDFSESESDADNindreyae----------------------nqs 127
EMG50041      79 ---------PSIMERLeEED-------------DEEDEDEEENE------------------------------------ 100
XP_002839842  91 wgvngdakggELANGKkRKAVAFEE--------DIDSASGTSSQSDS--------------------------------- 129
XP_002173877  74 ---------------------------------DVDVSDEEQGSDSVtgsaaevs----------------------dve 98 
EPY51748      76 ---------------------------------DVEEDRPSDEESYAsedsqeen-----------------------qf 99 
O13910        74 ---------------------------------DVENEDEEEDSITSfqdedde-------------------------t 95  Schizosaccharom...
7MQ8_NA      129 -----DLEdleeeevSDMGNDDPEMGER------AENSsKSDlrkspvfSDEds--------dlDFDIS--KLEQQSKVQ 187
Q6CRE2       129 eeeeeAEN-------EELVLDEEQQFSEpeplelHEKEeDKL-------ENEsdsepddqfveaQESPQ--AIED----- 187 Kluyveromyces l...
CCE92651     143 aeeelVEN-------GSSEVEKEEPEII------GDANeEEN-------SHEv--------------------------- 175
XP_002551917 138 saglpINN-------SDDEYHSEVR---------EGHNsNRG-------SGDegseeeeggannSDGAE--EITVGPKKD 192
CCE82181     128 dfseeHDG-------NDDFSESEGSDEE------EEEEeDAN-------DKYpgsedrtstdfaKNDEE--ANVDQESKD 185
EMG50041     101 -----EEN-------EEEENKEEFEEEN------EGFEgFEE-------DDVegseeddeeaeePEDVE--EGSDAETLI 153
XP_002839842 130 -----EED-------EEVDDDEDLGEEE------YEEPmDED-------GGIalpdddddeegiEEDSE--EGGEEFVQD 182
XP_002173877  99 ynedeEMS-------VDGENSEEEELDG------EEQEdEED-------EDEfqgfddeadnaeVDVVE------KPKKD 152
EPY51748     100 ealpaENP-------AEDVENEEEEFLGfsdrgdEENDhLSD-------ENIenedletgnsneEDENEqvQEDQEPKKD 165
O13910        96 shqelSDN-------SEMNNRDDADDEFlg---fSGPEnLED-------VDEssaedvsgdeaeIMNEE--GQQIEQKKD 156 Schizosaccharom...
7MQ8_NA      188 NKGQG------KprekSIVDDKFFKLSEMEAYLENIEK--EEERKDdndeEEED------IDFFEDIDS-----DEDEGG 248
Q6CRE2       188 -----------K----FGVNDQFFNLDEFNRQTLEAEN--RSQDADeedeDDEE------VDYFADVPS-----EEDEEA 239 Kluyveromyces l...
CCE92651     176 -----------L----SGVNDDFFNLEEFNKQTLEPEGgrAEQE------DDEE------IDYFENVPS-----DDEEEA 223
XP_002551917 193 -----------S----FGLNDEFFDLEEFNRQTIDNEN--TAE-------PDNE------INYFEDVPS-----EEDEEV 237
CCE82181     186 ANDNVegfsrdA----FGLNDGFFDIDKFNEQILDMED--ANA-------DDEE------IDYFEDLDE-----KDDEDD 241
EMG50041     154 NDTHTk----dA----FGLNDGFFDIDHFNKQILSMEK--DNNINDe---DEEE------IDYFGSLSE-----SDDEED 209
XP_002839842 183 -----------V----HGLNDGFFSIDDFNRQTRLLEM--QDERGElg-sDEEE------IDYDADPDQladndEVEDEG 238
XP_002173877 153 -----------A----FGLNDQFFDIDAFNKQTLEMEE--QDESQTialnDDEDeenedeIDVFGDVDE---------EE 206
EPY51748     166 -----------V----FGLNDKFFDIDEFNKQTLALEEqeDEQNHEigeeEEDD------IDLFVDPEE-----EDEEEE 219
O13910       157 -----------A----FGLNDGFFDIDNFNKQTLALEE---EAVEEgvlgDEDDg-----IDLLMDPDE-----NMEDSE 208 Schizosaccharom...
7MQ8_NA      249 lfgskkl-----------ksgkssRNLKYKDFFDPVESdeditnvhddeldsnkeddeiaeeeaeelsisetdedddlQE 317
Q6CRE2       240 --------------------------LYYDDFFDKPSNkkssqdrrpgp------------------skkaeaeedesFD 275 Kluyveromyces l...
CCE92651     224 --------------------------IYYEDFFDKPNTkkrttggdkn---------------------slntkkiddLD 256
XP_002551917 238 --------------------------LYYDDFFDKPSSskrkvtsggdk-------------------qvkfgehgedFH 272
CCE82181     242 ------------------------EIAYYEDFFDRPNKqdvsskekkdadnkf----------dfsdnsqsegegedeNE 287
EMG50041     210 ------------------------EMDYYDDFYDKPGQfkqkvshnsqdg----------------deddeddegeevFN 249
XP_002839842 239 givtvgnddydeedgdlhdsydnsNGIMYQDFFAPPAKkgskkrlskvskpwn----------qrtkrleeeleregsNI 308
XP_002173877 207 gp--------------------qaDSIMYEDFFGPRNPrdrrqqvqakkra--------------alkkkkrpvaeepSD 252
EPY51748     220 ggp-------------------raDSILYEDFFGPKSAkgrrevskkkkrdad----------askkkkakrvpkpeeSD 270
O13910       209 desn----------------gpqaDSIMYEDFFGPKTAagrrelkkkkae-----------------skrkrtskpdfKN 255 Schizosaccharom...
7MQ8_NA      318 N-------------EDNKQHKES---LKRVTFALPDDAET--EDTGVlnvkKNSDEVKSSFEKRQEKMNEKIASLEKELL 379
Q6CRE2       276 E-------------SEYDDAMEE---AKLDLFADEDDDFQgsDE-------ETAEQPLSTFERQQLELKRQIESLEKEAV 332 Kluyveromyces l...
CCE92651     257 E-------------ADYEAAVDS---AKLDLFAEEGDDSEidEDD------KDVEGKLSTYERQQIDIQNQIEQLEKDAV 314
XP_002551917 273 Ens----------dDEYDRAMES---AKLDLFAEVEDDEMkpE--------VDPVSKLSTFQRQQLDIQRQIAQLEKEAV 331
CCE82181     288 E---------------YSHAISS---ARKDLFDDDMSEDDdkE--------SQKPANMSSFEKQQQQIQAEISKLESDLV 341
EMG50041     250 E-------------DDYDNAVGS---AMLDLFAEDDKETK-----------PKSAENLSTFEKQQRSIQAEIAKLEAELV 302
XP_002839842 309 E--------------------SEmarVRRDLFDDDVSEEGsdFDMDDd--lANPISHRSTHEKRQATIIEQIRQLEAANV 366
XP_002173877 253 Deevanv-eedeeeEDAAQTFER---VRQDLFASDSEEEQddGT------------GLSAYERQKLELTKQIRALEAENV 316
EPY51748     271 Eeedq------eepQNDDNTFER---VRKDLFADEEEEEN-----------ENSQQLLSSYERDKARISQQIKELESENV 330
O13910       256 DvqqnvieennessDNEYATFDR---VKKDLFASDEEDDVsaD-------------QLSSYERDKARLTQQIRELEAENV 319 Schizosaccharom...
7MQ8_NA      380 EKKPWQLQGEVTAQKRPENSLLEE----TLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEYK 455
Q6CRE2       333 AEKKWALKGEVKARDRPEDALLTE----DLEFERTAKPVPVITAEVTETLENMIRRRIKEEDFNDLQRRVISDISGYNNK 408 Kluyveromyces l...
CCE92651     315 AEKKWALKGEVGAQDRPADSLLTE----EVDFDRTAKPVPVITSEVTESLEQLIRRRIQEYNFDDLQRRVVSDLNLKKMK 390
XP_002551917 332 AEKKWALKGEVKAGDRPEDALLTE----DLDFERTSKPVPVITSDVTESLEDMIRRRIQQREFDDLARRVEANLNFSSAK 407
CCE82181     342 AEKKWTMKGEVSAKSRPQDSLLEDpeaiDLEFDRASKPVPIVTEDFSESIDDVIRRRIKEEQFDDLPKRYISDLEKHDRR 421
EMG50041     303 ADKKWTMKGEITSNDRPQESLLDEt---DLTFDRTAKPVPVITEESTQTLEDLIRKRIKEDDFNDLPRRIITDISRFHKA 379
XP_002839842 367 AKKQWTLAGEARSTTRPLNSLLEE----DLDFERAGKPVPVITQEVTEDLEEMIKRRIIASDFDEVIRRRPDDISSRFRR 442
XP_002173877 317 AKKNWTLMGEASSKQRPQNSLLET----EVDFEQNAKPVPVVTEESTDTLEDLIKSRILDKNFDDIPRRLVSAVPDFKPS 392
EPY51748     331 AKKPWTLIGEATSKSRPSNSLLDV----DIDFETGAKPVPVQTEETTSALEDVIKNRILEKRFDDVPRKAPSSLPEFRPS 406
O13910       320 AKKSWTMMGEATSKGRPSNSLLDV----DLEFETGAKPVPVQTEETTETLEDLIKNRIISKTFDDVPKRAPVAVTEFRPS 395 Schizosaccharom...
7MQ8_NA      456 KRLTLDHEKSKLSLAEIYEQEYIKL-----NQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPV-PEIKVV-- 527
Q6CRE2       409 PRFELSDVKSSKSLAEIYEDDFKGVt----EDTEISEELQKSHDEISELYKDLVYKLDALSSAHFIPKPIK-KDLEVR-- 481 Kluyveromyces l...
CCE92651     391 PQFELSDQKSSKSLADIYEDDYKNVp----QDVAVSEELKKSHDEISEMFSNLCYKLDALSSAHFIPKPAQ-KSLEIR-- 463
XP_002551917 408 PQFELSDSKSSKSLAELYENDYNNIp----QDSEVSEELKKSHAEISDLYSKLVYSLDALSSAHFIPKPAQ-KTLEVR-- 480
CCE82181     422 PAFELSQEKSKKTLAEIYEEEYSGA-----QDNSKSEETEKLHSEIGNLFENVTYMLDSLCSAHYIPKPHQtKTIEIK-- 494
EMG50041     380 PKAEVSEQKSSKSLAELYEDEYNQId---aQQESLNEEVKKQHDEISELFTKVTHKLDALCSAHFIPKPHQlKTIDIKvt 456
XP_002839842 443 GRIELDDSKPQQGLAEIYEREHLQKidpenNPDIKDEKLAEAHREIGELFSDVSRKLDALSSWHFTPKPPK-PAISIV-- 519
XP_002173877 393 QLFDLDENKPQRSLAEEYEEEYLKKsdpttFQSKEDKKVEKEHEEIKGLFNSVAHILDSLSSWHYVPAPAE-ASVEVV-- 469
EPY51748     407 ELFELDENKPQQSLADIYEEQYMKKanpdtYQSGVDKKRQDDYNEIKTLFEDVSYTLDALSSWHYIPAPAE-ANVQVV-- 483
O13910       396 ELFELNENKSQRSLAEEYEEEFLKKsnadtYKSEADKKKEKEHEEIKALFSEVSRTLDSLASWHYVPPPPE-STVEIV-- 472 Schizosaccharom...
7MQ8_NA      528 -SNLPA-ITMEEVAPVSV------SDAALLAPEEIKEKNKa------------------GDIKTAAEKTATD 573
Q6CRE2       482 -VQTAA-ISMEDAQPLTM------SSGSTLAPQEIYKVGKsensne--------itlknGVVMSRDELSRED 537 Kluyveromyces lactis
CCE92651     464 -VDSAA-ISMEDAQPLSM------SSASALAPQEIYKVGKsnntne--------irlknGVTMSRDELTRED 519
XP_002551917 481 -VQTPA-INMEDAQPLTM------STAPTLAPQEVYAPGAsrstne--------islknGVVMSRDELSKDD 536
CCE82181     495 -ASDAAeINLEDSQPAVV------GSGSTLAPQEIYSLKNkgnenkaa----nqislksGLSYSKDELPREE 555
EMG50041     457 dSSSPA-ISMEDAQPLHV------SSESRLAPQEIYKIGDdvvkgdgvk-gksqvqlksGLSYSKDELSRED 520
XP_002839842 520 -VDAPA-ISMEEAQPSAVdggalaANISMLAPQEVYAPQKgravatigegggreivgksGAPVSTREMTRED 589
XP_002173877 470 -ANAPT-LSMEDVQPAAA------SETMALAPQEIYNATQgertde--------tvtrsGIAISKAEMNHQE 525
EPY51748     484 -SNAPT-LAMEEAQPTAS------SDAMALAPQEVYQPSMdnrqne--------tversGIAVSKAEMDHSE 539
O13910       473 -SNAPT-LAMEDVQPTAA------SDTMALAPQEVYKPSNenrege--------titrsGIAISSTEMDHQQ 528 Schizosaccharomyces pom...
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