6SWY


Conserved Protein Domain Family
Vac_ImportDeg

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pfam09783: Vac_ImportDeg 
Vacuolar import and degradation protein
Members of this family are involved in the negative regulation of gluconeogenesis. They are required for both proteosome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase), where they probably regulate FBPase targeting from the FBPase-containing vesicles to the vacuole.
Statistics
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PSSM-Id: 462897
Aligned: 79 rows
Threshold Bit Score: 140.358
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SWY_4        122 YLRPRMQFTGYQ------------ISG----YK-RYQVTVNLKTVDLPkkdctslSPHLSGFLSIRGLTN---QHPE--- 178  Saccharomyces...
Q5ZBM4         33 LLSAGRCYAGTQnv---------sTIQ----KEeAWKVNVRINDCDLE-------QGYLCGTMEAVNVPL---ADTP--- 86   Japanese rice
EEA27599      447 HQS---------------------QSS----KHeLWPVKVTIHSVDYS-------TMTLSGTMEAYNIPD---KTSPtrd 491 
EHA19068      316 YTTTGRRYLANNiy--------hlGGG----KDeNWPVKVTIHSINPD-------DMTLSGTMEAYNIPD---KTTPahd 373 
Q0CTA5        393 YTSSGRRYLANNiy--------nlGAG----KDeNWPVKVTIHNVNEH-------DMTLSGTMEAYNIPD---KTSPshd 450  Aspergillus t...
EMR10491      182 WLKSGSIFQGVQnfpgqpsiflseSSH----IRdERKIKVIIQDINFS-------KMSVSGQIEMFNASDvdfNNSS--- 247 
CCJ28884      928 WLKSGSIFQGVQtfsdqasvflseSSS-----KnEKKIKVVIQDISFS-------EMSLSGQIEVFNPSDn-gSNGS--- 991 
Q9UT04        350 WLRSGSVFRGLQfggvqsisglppLTN----PKeRWIVDVSIHVVDYK-------RRALEGQLNAQARSSd--PSST--- 413  Schizosacchar...
XP_005848565    4 FLRPGQSFEGGQrv---------aHHHgaipKQeTWEVKAVIQHYDPA-------KGYVAGTMEGGNVPD---MPAP--- 61  
XP_002957890   77 FLFPGRSFTGQQ------------RLSsphrQQeDWAVTATIYSCDLS-------RGRVTGSMVAQNSPL---AKRP--- 131 
6SWY_4        179 --ISTYFEAYAVnHKe-LGFLSSswkdepvLNEFKA--TDQTDLEHWINFPSF-RQlFLMsqknglnstddngttnaakk 252  Saccharomyces...
Q5ZBM4         87 --VVTFWEGEIVdAKn-YTFFTG---------KWEA--SPEDDIRHWSKFPSF-TPlLSQietdg--------------- 136  Japanese rice
EEA27599      492 ahIITFLEGEIVdLNa-HSLETT---------SFQA--DADIDCTYWRELRPF-RGlS---------------------- 536 
EHA19068      374 ahIVTYLEGEIIdFNk-HTLETK---------NFKA--DAEIDSTYWRELQPF-KNlS---------------------- 418 
Q0CTA5        451 ahIITFLEGEIIdFNr-HTLETK---------NFKA--DAEIDSTYWRELQPF-KNlT---------------------- 495  Aspergillus t...
EMR10491      248 --IIIWWNGEIVdFvgyYNLLAVk-----rGIAW------KTDVAYWRKLEPF-KGm----------------------- 290 
CCJ28884      992 --IMIWWDGEIVdFigyYNLLAVk-----rGIAW------KTDVSCWRKLEPF-KGm----------------------- 1034
Q9UT04        414 --ISTAWTGEILdFsekLNFATE---------KWSA--PLEIDVCYWRKLAPF-QNm----------------------- 456  Schizosacchar...
XP_005848565   62 --VTTFFEGEVIdNRn-FTFFTA---------DWDA--CADTDFLHWSKFGPF-RQlHAQvvrhg--------------- 111 
XP_002957890  132 --IVTYFEGEIIdNi-nHIFWTG--------NKWGAcpSRETDLRYWSRCPGFtSAlRAAvqqhh--------------- 185 
6SWY_4        253 lppqqlpttpsadagnisrifsqekqfdNYLNE---------------RFIFMKWK------------------E-KFLV 298  Saccharomyces...
Q5ZBM4        137 ------------------------gksvDFSNY---------------AYIFMRWK------------------E-QYFV 158  Japanese rice
EEA27599      537 ----------------------------DDQMTknllsktwvtdelnkNWILMRWK------------------ErCFIT 570 
EHA19068      419 ----------------------------DEEMTrklvsrkwvteqlskQWILMRWKgefrlreslqnktniralErCFIT 470 
Q0CTA5        496 ----------------------------DEEMTrnlvsrkwiteelsqGWILMRWK------------------ErCFIT 529  Aspergillus t...
EMR10491      291 ----------------------------DDYEFfnllfakdkitdicsKYIFMRWK------------------EsEFIG 324 
CCJ28884     1035 ----------------------------DDYEFlnllftk---------------------------ekisdicKsEFIG 1059
Q9UT04        457 ----------------------------DTNTFletitnpkklykicqKYIFMRWK------------------DmLILK 490  Schizosacchar...
XP_005848565  112 ------------------------grcpALAAH---------------PYVYMRWK------------------E-QFFV 133 
XP_002957890  186 ------------------------grapQLGTC---------------PHVFMRWK------------------E-CFFV 207 
6SWY_4        299 P-DAlLMEGVDGASYDGFYYIVHDQVTGNIQGFYYHQDA-EKFQQLELVPS 347  Saccharomyces cerevisiae S288C
Q5ZBM4        159 -----NVGVDCGLTIAGFYYVCFSCSDGSISGYYYDPNS-SPFQKLELKCT 203  Japanese rice
EEA27599      571 PtDA-----RQGLTISGFYYISLRRGTGEIEGLYYDPGS-SPYQQLSLKPE 615 
EHA19068      471 PtDS-----RQGLTISGFYYISLNRQSGNIEGLYYDPGS-SPYQQLSLKPE 515 
Q0CTA5        530 PtDS-----RQGLTISGFYYISLHRESGHVEGLYYDPGS-SPYQQLSLTPE 574  Aspergillus terreus NIH2624
EMR10491      325 P----FMFE-SDFATSGSYFCCLRRNDGFIEGYYFDPSL--SCQYISLYpk 368 
CCJ28884     1060 S----SIFE-NELATSGSYFCCLRRNDGFIEGYYFDPSV--SCQHINLYPk 1103
Q9UT04        491 D----QTDT-SESRITGFYFCCLCRENGYIQGYYYDPKHaFCSQPLNLFPE 536  Schizosaccharomyces pombe 972h-
XP_005848565  134 -----RGSE-CRLTIAGFYYLAINRASGKVTGYYFDPSS-SPDQKLELTPV 177 
XP_002957890  208 -----DVPQDCPLTITGYYYLSLDRQSGSIGGYYHDARS-APLQVLQLQP- 251 
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