Conserved Protein Domain Family
Q_salvage

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pfam10343: Q_salvage 
Potential Queuosine, Q, salvage protein family
Q_salvage proteins occur in most Eukarya as well as in a few bacteria possible via horizontal gene-transfer. Queuosine (Q) is a chemical modification found at the wobble position of tRNAs that have GUN anticodons. Most bacteria synthesize queuosine de novo, whereas eukaryotes rely solely on salvaging this essential component from the environment or the gut flora. The exact enzymatic function of the domain has yet to be determined, but structural similarity with DNA glycosidases suggests a ribonucleoside hydrolase role.
Statistics
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PSSM-Id: 463052
Aligned: 111 rows
Threshold Bit Score: 257.816
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5BAH9               81 LHPK----AKd----E-STVDFIFTMDLLNFSFWSAEpEGKRFAIEYRGKKWTgywslvaalrraldeGIEITNPEFWVD 151 Aspergil...
EFN61472             55 YHPDk---YD-----H-RAADWLFVLNTMNFALWNPK-GTKQWTV----NQLTgyqalcaaikraidnNRPIWDPKYYTK 120
WGS:AAPU:GI19014-PA  54 LHPKa---TD-----E-HAANWIFLVDTLNFCFWT-----PQNYTKYKVNGYTgyfalcaainramseGLDITNPEFYSE 119
Q9W2I2               55 LHPNpnqpED-----YsKAADWVFVLDTLNFCFWT-----PNNYTKYKVDGYTgyfalcaaikraikeGVDVINPKFYSQ 124 fruit fly
WGS:AAQB:GK21592-PA  57 LHPQpgkdSNedpkyG-EAADWIFVVDTLNFCFWT-----PDNYTKYKVDGYTgyfalcaaikravdeGIDIISPKYYSQ 130
XP_974460            52 LHPKs---DD-----P-KALDWLFVVDTLNFCFWH-----LETEAGWTVEGYTgyfalcaainravkeKVDILNSKYYSE 117
XP_012545868         55 IHPNv---EH-----P-RAVDWVFVADTLNFCFWS-----YSGVLKWTVGGHSgyyaleaaldraikeGYDITNPEYYSK 120
OWR49020             55 IHPDk---TH-----P-KAVDWVFILDALNFCFWS-----KNKETQWTVCGYTgyyaleaalhraiqeDINILNPEYYCK 120
ESO09264             58 LLPQt---QD-----E-FAANWIFLSDLLNFCFWSS--PGKEYMVHYKSKNRTgywslcaalwralddGYDITNPAFYSK 126
XP_015786129         55 LHPKe---PT-----D-FAVNWIFLVDSLNFSFWPD--EDKEFGVTYKDIEYTgywalcaiinraldqGIPMCNPDYYSN 123
Q5BAH9              152 EEEcseELIRHVFRSA-TD--ED---MPLLKERLEC-LREAGRVLCNDFDGSFTNCIYSSNRSAAALVNLLAESFSCFRD 224 Aspergil...
EFN61472            121 LTR---YGLENIFKSDdGE--TN---IPLIHERLEI-LHKVGTVLLRKFQGSFMRCIQLCNRNPVKLLQLIVHEFVSYND 191
WGS:AAPU:GI19014-PA 120 IDR---QTLSSIFRPDdET--TK---IPLLDKRLLC-LHQVGKRLLTNWQGRFENVVKAANHSAVALLKLIVDEFPCFRD 190
Q9W2I2              125 IDL---KTVENIFRSDdGE--TV---IPLLQKRLES-LHEVGKVLIDKYDGSFENVIKKAEKSAVRLLDLVVEEFPCFRD 195 fruit fly
WGS:AAQB:GK21592-PA 131 VDA---KTLDHIFRSDdGE--TK---IPLFQQRLDS-LHEVGKVLLDKYEGRFENVIKAAKSSAVSLLQLVVQEFPCFRD 201
XP_974460           118 VSE---KDLAKIFRSD-ND--VP---IPLLQERVKC-LHEVGNVLLETFDGSFENCVKKADKSAVALLDLIVNNFKCFKD 187
XP_012545868        121 ITT---EQLEMIMRGD-NE--AK---IPLFTERMSV-LHETGAILLEKYNGTFTTCLKEANKSALKLLEIIVNNFPSFRD 190
OWR49020            121 ITN---SELSNILRGD-TD--AV---IPLLDKRLSV-LHEVGNILIKKYNSTFETCLKDSNKSAVKLLSIVVENFPCFRD 190
ESO09264            127 IDE---STLKKIFRSD-SN--YD---IPKLHERHCImLKD-GEILLKNFNGSFLNVVKACNNSAENLVNLITKEFTSFTD 196
XP_015786129        124 LSL---DQVKRIFAAHrKGkpNEpmdLPLLEERHAI-MRENGSVLVKKFSNTFVSMVIKAKNSAKTLLKMVHEYFPSFRD 199
Q5BAH9              225 EVV--FQGRRVRFYKRAQILVADLWACFDGEGYGEFQ---DIDKITMFADYRIPQMLHFLGCLMYSPSLETRIR-KQEEI 298 Aspergil...
EFN61472            192 APLckDAGK-VYLHTKAQILLSDIWVCFKGHELG-FDyniDVMYSMIFVDSRVSQILRHFKLLEYSTKLMNKLE-NNEPL 268
WGS:AAPU:GI19014-PA 191 EAI--FAGKRVALWKRAQILVGDLWSCYRGQGLGQFD---DIEMVTMFADYRVPQVLVHFGSLQYSPELLEVLQ-KDTIL 264
Q9W2I2              196 EAE--FAGKRVSILKRAQILVGDVWSCYRGQGLGFFN---DIDQITMFADYRIPQVLVHFGSLEYTSELMEFLK-TDTIL 269 fruit fly
WGS:AAQB:GK21592-PA 202 QAE--YAGKHVSILKRAQILVGDIWCGYKGEGLGFFN---DIDKITMFADYRVPQVLVYFKSLEYSEELLEVLN-KDTIL 275
XP_974460           188 EAT--YKDKKIAIYKRAQILIGDIWACFKNEGLGHFK---DIDEITMFADYRIPQSLLYFGVFEYSEDLKKKLQ-DNKIL 261
XP_012545868        191 EAV--YKGQKLGIYKRAQILVADLWNFFGGKSWGEFE---DIDKITMFADYRVPQVIVYFGALSYSDELMEKLK-NDILL 264
OWR49020            191 EAV--YKGQRVSLYKRAQILVSDLWNFYDGSGWGEFH---DIDEMTMFADYRVPQVLVYFGALTYSDELMEKLN-KDMLL 264
ESO09264            197 QIN--FQNVEVSFYKRAQILVADIWSCFGGKGYGRFH---DIDTITAFADYRVPQVLNWFGALKYSEELTSLLKkEGTTF 271
XP_015786129        200 ELL--YNGESIGFYKRAQLLIGDIYACHEGKGLGKFD---DIQDITMFADYRVPQCLYYLGVINYRDELLRRLS-AGEKF 273
Q5BAH9              299 PSGSNWEIELRATSIWCVELIRREIEKQH-PEVKsvktekstsnghsslshsnglshpnghcretsqtqngnddqmdtqa 377 Aspergil...
EFN61472            269 EYGSTEEIEIRSCLIFIIKLVAKDLKFIY-NNNKmeni------------------------------------------ 305
WGS:AAPU:GI19014-PA 265 ENGHAMEVEIRGASIHIIEQVKDAVLAQL-KEHHpdv------------------------------------------- 300
Q9W2I2              270 ENGDPREVEIRGASIYIIEQVRDAVVKIL-KEQHpei------------------------------------------- 305 fruit fly
WGS:AAQB:GK21592-PA 276 ENGDPREVEIRGASIYIIEQVRDQVLGLLqKDQHs--------------------------------------------- 310
XP_974460           262 ENGEEDEVEIRACSIHAVELLKEHANKKL-TDTK---------------------------------------------- 294
XP_012545868        265 QSGSEEEIEIRGCSIHAIELIKKRLEDAL-KKTGgd-------------------------------------------- 299
OWR49020            265 PNGSEEEVEIRGCSIHAVELIKEKTGQLI-KEAAlr-------------------------------------------- 299
ESO09264            272 AHGDRWEIEIRGCTIHCIELIVKKVNETL-ESLPsst------------------------------------------- 307
XP_015786129        274 KYGDPDEVEIRGVSIHAVEQIKNGVVRLA-EINNvtl------------------------------------------- 309
Q5BAH9              378 pqtghfrrhsrhssaasnaplgtgvSIN-AILIDFFLYDTMKELEKQGrenstfifTETLSAGSRDVYT 445 Aspergillus nidulans
EFN61472            306 ----------------------semNINfFVVVNNFLWDYR-QEYDQLl------mETQPFPNIKCVYY 345
WGS:AAPU:GI19014-PA 301 ----------------------dtrNVN-SILIDQYLWDYRRAHAAEL--------EHIPFHKVLSIYY 338
Q9W2I2              306 ----------------------sldNVN-SIVIDQYLWDYRRRHNADL--------EHIPFHKVLSIYY 343 fruit fly
WGS:AAQB:GK21592-PA 311 -------------------------sVN-SVLIDQYLWDYRRKHQEKM--------ADIPFHKVLSIYY 345
XP_974460           295 --------------------------IN-AILIDHFLWDFRREHNKEIv------eKKLPFHKTFSIYY 330
XP_012545868        300 -----------------------ieLPN-SGLIDYYLWCYRRKYADEM--------ESIPFHKTLGIYY 336
OWR49020            300 -----------------------teVPN-SSLIDYYLWCYRRKYAQEM--------EKIPYHKTLSIYY 336
ESO09264            308 ----------------------tnlKVN-SIIIDHYLWDMRREKAKEL--------ESVPYHRTESIYY 345
XP_015786129        310 -----------------------piPAT-SVIVDFYLWDLRRSRPDEId-------ECITYHKTRSIHY 347
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