Conserved Protein Domain Family
TRH

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pfam05438: TRH 
Thyrotropin-releasing hormone (TRH)
This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH; pyroGlu-His-Pro-NH2), originally isolated as a hypothalamic neuropeptide hormone, most likely acts also as a neuromodulator and/or neurotransmitter in the central nervous system (CNS). This interpretation is supported by the identification of a peptidase localized on the surface of neuronal cells which has been termed TRH-degrading ectoenzyme (TRH-DE) since it selectively inactivates TRH. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.
Statistics
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PSSM-Id: 461653
Aligned: 13 rows
Threshold Bit Score: 148.023
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003439044   6 LLILASLTVCNLMVSGGQSMSAEDETDRK------TIDDIiLERAET-LLLRSILKKLQDEDGRNDG-----YYS--QPE 71 
XP_005805715   6 LLVLASFVICNLAVCDGQGLPAEDEMDRSt-----TIDNLmLQRAQS-LLLRSILKKLQDGDVRNDG-----IFS--QPE 72 
Q1T735         6 LLILASLAICNFTVSDAQSISAEDETDRTt-----TTDDIiLRRAES-LLLRSLLKKMQDEDDINDG-----VYA--QQD 72  Japanese medaka
XP_003963468   6 LLILASVVVCNLIVCGGQGIPDEDELDRM------AIDDIiLQRAEG-LLLQSILRKMQSEDGRS-G-----ESS--QID 70 
XP_001491323   6 SLLAMALTLTLTGVPGGRSQPEAAQQEAAmgaehpGLDDL-LRQAERlLLLREDLQRLREDQGERES-----ESQifQPN 79 
XP_017893978   6 FLLAMALTLTLTSVPGGRAQLDVAQQDVDlse-qqGLEDL-LQQAERlLLLREDLQRLREDQDDSVS-----ESQifQPD 78 
XP_005053391  64 pLLLLCLTLCGVCFNGGHLLPEESKNMGKs-----PLDDI-LQRSES-FILQSVLKKAEKEEEINKE-----SNAp-LLQ 130
XP_012948030   7 pLLLLCLTLSGVCLNGGQPLPEASENMGRr-----PLDNI-LQRSES-FILQSVLKKAEKKEEMNKE-----LNAp-LPE 73 
XP_003210272   7 pVLLLCLTLSGVCLNGRQSPPEVREKMGRs-----SLDDI-LQRSGS-HMLQSAVKKLEKKEEMNKE-----LNVp-LPQ 73 
ALD51569       6 LLALALLVVCNFTVSGGQSIPAEDETGGR------TIDDIiLQRAES-LLLRSILKKIQDEDGGDEG-----FPP--QAE 71 
XP_005997878  39 LLLLVSLGLSSMTAVLGQHAPEGVESEESv-----PMDDL-LQQAES-ILLRSILKKMEEEKDLHDP-----TAS--QVE 104 coelacanth
XP_015202805   6 LILLVSLTVCNLTVNLGQNIPDESDKEERv-----PLDDI-LQRAQN-IIFRSLLKKIEDEDKLNDQ-----VSS--QQE 71  spotted gar
XP_006083864   6 LLLALALTLTLTGVPGGRAQLEVDQQEAAmaaehpALRDL-LRQAGHlLLLREDLQRLQGDQGNRESesqifQS-----N 79  little brown bat
XP_003439044  72 WVTKRQHPGKRYSDDLEKRQHPGRREEDE------------------DEQYFDVQKRQHPGKRED--------------- 118
XP_005805715  73 WVTKRQHPGKRHFEDLEKRQHPGRREVVD------------------DEQFWDMQKRQHPGKRED--------------- 119
Q1T735        73 WMAKRQHPGKRYREDLEKRQHPGRREEDE------------------DEEYLNAQKRQHPGKRED--------------- 119 Japanese medaka
XP_003963468  71 WVTKRQHPGKRYMEDLEKRQHPGRREESE------------------DD--LDVQKRQHPGKRDD--------------- 115
XP_001491323  80 WLSKRQHPGKR-EEEAEE----RVEEEEA------------------EEGAVGRHKRQHPGRRED--------------- 121
XP_017893978  79 WFSKRQHPGKREEEEADE----GVEGEEE------------------EGGAVGLRKRQHPGRRDD--------------- 121
XP_005053391 131 WLSKRQHPGKKYLSNLEKRQHPGKRDVEE------------------ETSYGDIQKRQHPGKREM--------------- 177
XP_012948030  74 WLSKRQHPGKRYISDLEKRQHPGKRDVKE------------------EASYGDIQKRQHPGKREV--------------- 120
XP_003210272  74 WLSKRQHPGKRYISDLEKRQHPGRRDVEE------------------AASFGDIQKRQNLGKTEG--------------- 120
ALD51569      72 WMTKRQHPGKRYGEDLEKRQHPGRREADV------------------DEPYLDVQRRQHPGKRED--------------- 118
XP_005997878 105 WISKRQHPGKRFQAELEKRQHPGKRDEDE------------------EIAYIEAQKRQHPGKRGGeeendnlqaqkrqhp 166 coelacanth
XP_015202805  72 WLSKRQHPGKRYQEDIEKRQHPGRREEDEdlrypdfekrqhpgrreeDDDYFEEQKRQHPGKRED--------------- 136 spotted gar
XP_006083864  80 GLSKRQHPGKR-EEEAEE----GVEDEEE------------------EGGAVGPHKRQHPGPWEN--------------- 121 little brown bat
XP_003439044 119 ------------E--THSFLEPQKRQHPGKRSTAGHSSDNP---ILLLSELSKRQHPGKRYLvlHSKRQHPGKRLLEDED 181
XP_005805715 120 ------------E--MHSFTEFQKRQHPGKRSTTGHIPDSP---VALLSELSKRQHPGKRYLvlHSKRQHPGKRLLEDED 182
Q1T735       120 ------------E--IQSSMGLQKRQHPGKRFLTGHISDNP---IIMLGELSKRQHPGKRYLvlQSKRQHPGKRYQDDED 182 Japanese medaka
XP_003963468 116 ------------E--MHSLVEIQRRQHPGKRTMMGHVTENP---VLLFSELSKRQHPGKRYLvlHTKRQHPGKRHFEEED 178
XP_001491323 122 ------------EaaWSADATQQKRQHPGRRSs----------wLGY--TFTKRQHPGRRLV------DPQAQRSWEDEE 171
XP_017893978 122 ------------VaaWAVDAGQQKRQHPGRRAs----------wLGY--AVTKRQHPGRRLV------DPRPQRSWEEAG 171
XP_005053391 178 ------------EddPDVYLELIRQQPPRRKSLLDQFANSPraqLTYANKLSTREHPGRRYP--MYKHQRPSKRGWNY-- 241
XP_012948030 121 ------------EddLASYLELKKRQHPGRRSLWDQHVDIPsarLTYLNVLSKRQHPGRGYL--MHKHQHPSKRGWND-- 184
XP_003210272 121 ------------Y--LANYLELKKRQHPGRRSLWDQSTDISnsqLTYLNELSKRQHPGRRYL--MYKHQHPSKRSWND-- 182
ALD51569     119 ------------E--MRPFTELQKRQNPGKRFAAGRVSENP---AVL--ELSKRQHPGKRYLvvQTKRQHPGKR---DGD 176
XP_005997878 167 gkrddaedddgdEg-LDEYTEVQKRQHPGRRSTLDQFTDSPntqLAFLSELSKRQHPGKRYLl-YNKRQHPGKRGWDK-- 242 coelacanth
XP_015202805 137 ------------E--TDDYVELQRRQHPGKRSLMDQYSDATdsqMGYQSDMSKRQHPGKRYLs-YNKRQHPGRRELEN-- 199 spotted gar
XP_006083864 122 ------------AaaWSVDVTPQKRQHPGRRSf----------wLGY--TFTKRQHPGRRLV------DPKAQRSWEEEE 171 little brown bat
XP_003439044 182 gdrd--wdaDADGEEDLAEMEKRQHPGKRFWDNSSADLgtNSPCDVLDPASCSKTS 235
XP_005805715 183 dea----dwTEDGEEDMSELEKRQHPGKRFWDNSSPELstSSPCDVLDSDSCSKTS 234
Q1T735       183 sdg----dwEAAEEVDLPELEKRQHPGKRFWDNSNPEL--GNPCDALEPDNCSKTN 232 Japanese medaka
XP_003963468 179 idgewdadaNADDVEDLAEPEKRQHPGKRFWDNSNPDLgtNNPCDVLDHTSCSKTS 234
XP_001491323 172 ----------EEREEGELMPEKRQHPGKRAL---------GSPCGPRGA--CGQAS 206
XP_017893978 172 ---------EDEDEGGELMSEKRQHPGKRAL---------GSPCGPRGP--CGQAS 207
XP_005053391 242 ----------EVDLYS----EKLQHPGKRHWNSGSSGD--TGPCNFQESFTCHKGs 281
XP_012948030 185 ----------ELDISD-HDGEKRQHPGKRHWDTDNPDY--AGPCDLQESSTCNTGs 227
XP_003210272 183 ----------ELDLGD-QNWEKHQNFGKRNRDSDSPDY--AGPCDLQQSAICNKgs 225
ALD51569     177 ddvd-wdadGEGGEEDLVEMEKRQHPGKRFWDTSSPDLgtNSPCDVLDPTSCRKTS 231
XP_005997878 243 ----------ELDYEDLQELEKRQHPGKRQLPPESPDY--GLPCDILDPINCSKTS 286 coelacanth
XP_015202805 200 ----------ELDAGDLQDLEKRQHPGKRYWDIKSPDYinNLPCDIKDPVKCNKAS 245 spotted gar
XP_006083864 172 ---------EEEEEEGELMPEKRQHPGKRAL---------GGPCGLQGD--CGQAS 207 little brown bat
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