Conserved Protein Domain Family
FAM83

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pfam07894: FAM83 
FAM83 A-H
The FAM83 family members include FAM83A-H. They are oncogenes that function as intermediaries in EGFR/RAS signaling.
Statistics
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PSSM-Id: 462308
Aligned: 55 rows
Threshold Bit Score: 313.712
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007498018  17 RSSESKPEFFYSEEQRLALEALVARGPEAFYEVLKKENIRDFLSELELKKILET-I-------EVYDPGSENlRDPRGPH 88 
XP_003220579  39 KKEISPSMLQHSETARLAVDAFLEQGEAGYLQAIAQEKELPFLSKVDMDYMSQH-SqsipespMKGRESGLNredsadra 117
XP_003228186  21 SFRLAKLDFSHNESVRLATDALLDGGHPAYLKALEDEGEVDFLSTVEAQYIKRN-AkepyyssD----GEVG-PRQNNDA 94 
XP_003760413  21 WSRLPKVDFSHNESARLALDALLDGGPESYQKALSKEGEVDFLSSVEAQYIQEN-AkqpfyakEQAGEGELG-LQV-NDS 97 
XP_012362081  21 WVRPARADFSDNESARLATDALLDGGSEAYWRVLSQEGEVDFLSSVEAQYIQAQ-AreppcppDTLGGAEAG-PKG-LDS 97 
XP_016082609  21 WTRPTRMDFSHNESIRLATDALVNGGLESYQETLGEEGEVDFLSSAEACYIQEN-Tsqp-ngaPQSPGGEWL-DLQESDV 97  platypus
XP_031408775  52 SLKSTKADFSHNESIRLATDAFLDGGTDSYLQTLSKEGEVDFLSSVEARYIKEN-AresyyaqESPTDGAAA-QRQ-NDG 128 turkey
XP_006007087  21 WTKLSEEDFSYSESARLATDALLSGGIEAYQRVLNEEGEVDFLSPSETQYMIEN-VtepnsttQDYLSGESE-ETQTSDD 98  coelacanth
XP_006636141  30 SSQLSRIDLSHNESVRLATDALLDSGLQAYEETLTAEGEVDFLSQAEKEYILRS-AkerspadESQAEEGEN-LGETAAP 107 spotted gar
XP_003211964  76 WREPTPLVLQHSETARLAVDAFLEQGERGYMSAVAEERELPFLSTLDMEYMSQQrSqsfpeanAKRDKEGDPadgdgss- 154 turkey
XP_007498018  89 EGPEphdkeengqgdadadlvpSLEYWPQKSDRSIPQLDLGWP-DT--IAYRGVTRASVYMQPPidGQAHIKEVVRKMIH 165
XP_003220579 118 ---------------sllsgvtSGTYFPMMSDVDPPQLELGWPtTVp-VTAYDQQEVSLYFQRD--KANNVKEILRSLIC 179
XP_003228186  95 RSLQ------------------SGTYFPLVSENSEPALLHTWStSEk-PYLKEKSSATVYFQTD--KNSNIRDLIRRCIN 153
XP_003760413  98 GSLQ------------------SGTYFPVLSEGSEPALLQSWGeAEk-PYLKEKSSATVYFQTD--KHNNIRDLIRRCIS 156
XP_012362081  98 SSLQ------------------SGTYFPMASEGSEPALLHSWAsAEk-PYLKEKSSATVYFQTD--KHNNIRDLVRRCIT 156
XP_016082609  98 DSLQ------------------SGTYFPQFSGGGEPDL--GDA-GK--PYLKEKSSVTVYFQTD--RHSSIRDLIRRCIG 152 platypus
XP_031408775 129 GSLP------------------SGTYFPTISDSSEPALLHTWItAEk-PYLKEKSTATVYFQTE--KNSNIRDIIRRYIN 187 turkey
XP_006007087  99 ITLK------------------SDS---LISDCSPPALAQGWPmYEkkYYFNGTSKVNVHFQTD--RSINIKDTIRQHIK 155 coelacanth
XP_006636141 108 TET-------------------SVTYFPTLSESEAPALDYGWPmAEsrYYLQGKPSVEVYFQTD--RSRSIKDLVREYIS 166 spotted gar
XP_003211964 155 ----------------lcseltSGTYFPLMSDVHPPELELGWPgMPi-LTVSGQTQATIIFQRN--KVNSIKDLLRSLIS 215 turkey
XP_007498018 166 QAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYVIVDEANVKYFLHMCERAQMHTGHMKNLRVRSIGGTEFFTRSATKF 245
XP_003220579 180 KSKSVIAIVMDLFTDMEILSDLMEASSKRHVPVYLILDEKNLKYFAEMCTKMDLTMDDFPNMRIRCVSGDTYYSKAGKKL 259
XP_003228186 154 KTSQVLAILMDVFTDAEIFCDILEAANKRQVFVYLLLDHSNLKLFTEMCDKLHVAEGYFKNISVRSVTGEVYCAKSGRKF 233
XP_003760413 157 KTSQVLVILMDVFTDAEIFCDVLEAANKRGVFVCVLLDQCGINLFREMCDKAEILDSHLKNISVRSVEGETYCAKSGKKF 236
XP_012362081 157 RTSQVLVILMDVFTDVEIFCDILEAANKRGVFVCVLLDQGGVKLFQEMCDKVQISDSHLKNISIRSVEGEVYCAKSGRKF 236
XP_016082609 153 KTNQVLAILMDEFTDIEIFCDVLEAANKRGVFVYILLDQRGVKLFNEMCNRAQILEIHLKNICIRSVAGEVYCAKSGRKF 232 platypus
XP_031408775 188 KTTQVLAIVMDVFTDTEILCDLLEAANKRMVFVYLLLDHGNINLFSEMCDKLQIAEDLFKNISVRSVTGEVYCAKSGRKF 267 turkey
XP_006007087 156 EANKVLAIIMDMFTDIEIFCDLLEATNKRLVPVYLLLDERNLKHFSNMCDDLHITGSHLKNFSIRSVSGNIYCSKTGKKV 235 coelacanth
XP_006636141 167 KATTVLAIVMDIFSDVEVFCDILEATKKRNVSVYLLLDHMNLHVFTEMCEKLQINSSYLTRMSVRSVTGDVYCTKSGRKF 246 spotted gar
XP_003211964 216 QAQTVIAIVMDLFTDMEILCDLLEASSRRHVPVYLILDEEYLKHFVEMCNKMSLTKDSFPNMCIRCLSGDTYYSKAGKKF 295 turkey
XP_007498018 246 KGALAQKFMFVDGDRAMCGSYSFTWSAARTDRNVISVLSGQVVEMFDKQFQELYLMSQ 303
XP_003220579 260 TGQALEKFVLIDCEQVLAGSYSFTWLCSQVHTGLVIHFRGKVVECFDREFRCLYAESR 317
XP_003228186 234 SGQIQEKFIISDWRYVLSGSYSFTWLCGQVHRNFLSKFTGQVVELFDEEFRHLYASSK 291
XP_003760413 237 SGQIQEKFIISDWRYVLTGSYSFSWLCGQVHRNFLSKFTGQAVELFEEEFRHLYSSSK 294
XP_012362081 237 AGQIREKFIISDWRFVLTGSYSFTWLCGHVHRNILSKFTGQAVELFDEEFRHLYASSK 294
XP_016082609 233 SGRIQEKFIISDWRCVLSGSYr------------------------------------ 254 platypus
XP_031408775 268 SGQIQEKFLISDWRYVLSGSYSFTWLCGQVHRNLLSKFTGQVVELFDEEFRHLYALSK 325 turkey
XP_006007087 236 SGQIQEKVIIIDCEYVLAGSYSFTWLSAHVHRHFITRFSGYIVKQFDEEFHHLYALSK 293 coelacanth
XP_006636141 247 SGQIKEKFVIFDCIHALAGSYSFTWLSAQVDKNMAVLFKGSSVKHFDLEFRQLYAVSK 304 spotted gar
XP_003211964 296 VGQVLEKFVLIDCDQVVAGTYSFTWLCSQVHTSLATHFRGQIVAEFDKEFRYLYAESK 353 turkey
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