7OKX


Conserved Protein Domain Family
EAF
?
pfam09816: EAF 
RNA polymerase II transcription elongation factor
Members of this family act as transcriptional transactivators of ELL and ELL2 elongation activities.3]. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. The N-terminus of approx 120 residues is globular and highly conserved.
Links
?
Statistics
?
PSSM-Id: 462913
Aligned: 97 rows
Threshold Bit Score: 52.2954
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
7OKX_O         16 LRLGESF--E---------------------------KRPRASFHTIRYDFKPASIDTSCEGELQV-----------GKG 55  
XP_001841245   19 VDVGSSLgrAlkarkaeresgapspapveaagrtrksKPPDRDFYSLRYNHKPSSVDQTKAGMIQFttkesprgsttKEQ 98  
XP_007327841   17 VNIGSSLnrAlkarkqggt----------ppatnprrNLPDRDFYSFRYNFKPPSIDATKPGTVEIkkg------rdKEK 80  
ESK93107       16 VNIGSSLgrAlkarkng-------------gpsqkrsNLPDRDFYSLRYNFKPSSIDSSKSGSIQVkkn------kdATH 76  
A0ZWU1         11 VIPGSSF------------------------------SKNSNGLLSIKYNFIPESVDPSRRGVLEK------------AQ 48   Schizosacchar...
XP_002174625   11 VVPGRSFr-----------------------------GSRKDALVAIKYNFKPDSIDNTKQGQLDK-----------NKD 50  
Q6CDB8          4 VTVSPELlkRgrk---------------------sggPNPLGDMVSIRYGFHPDSLDHKSKMQLEEdkdkgnwvlrgSGG 62   Yarrowia lipo...
CCF53266       12 IAIEPSAasLlsshlqss------------snhsdstSQSLPNYFALNFNFKPDSTQDCKKGALFQpgp------srSQN 73  
GAC76795      746 VAVEPAAseLlhavsnt-------------ngrsaglAEPLSSLFALNFNFKPDSTHDCKRGALFQpgp------grSDT 806 
XP_012189708   12 VAIEPSTaaLlsavsqt-------------gtsqaniRSSLPNYVALNFNFKPDSAHDCRKGALFQpgs------ssNVN 72  

7OKX_O         56 DEVTitlphipg------------stppmtvFKGNKRPY--Q-KDCVLIINHDTgeYVLEKLSSSIQVKKTRAE 114 
XP_001841245   99 TTVIveqasvq--------------pnesvmFRGHEMIPskNnFDCVLIYDEDTatFTLEKLDGCVLLTYDRSL 158 
XP_007327841   81 SQVAlelssq---------------ageaniYAGNETQA--KeWDCVLVYDDETgaYTLEKVDSFVSLTFERKR 137 
ESK93107       77 NSIIvehpvsq--------------tndvhvYKGREEPA--KeWACVLIFDEETggYTLEKIESFVALEHVEKR 134 
A0ZWU1         49 EAYRlrlpstf-------------dddrphiFEGSCQRA--RnVDCVLIFNAKTktFTLEHIDEIARLNALRNP 107  Schizosaccharomyces...
XP_002174625   51 NTFTlqlpsss-------------dpqechsFQGQAQQA--RnVDCVLTFDPETqtFTLDHLDSVIRFNALRNR 109 
Q6CDB8         63 GNGTh-------------------------tFSGGVAPA--SdLECVLVWDAPSnsYVLHPLDATLRVSRDKAA 109  Yarrowia lipolytica
CCF53266       74 AEWHfelesnehdtda---ngesggkkpahvFTGPQTAA--KaYDLVLVWDAAAkvYRLDRVAATFALKYERSK 142 
GAC76795      807 SEWQmeleatdahaesstsainsatkkpahvFTGPQTTA--KaYDLVLIWDDDKqtYRLDRVAASFALKYERSR 878 
XP_012189708   73 ADWQlelestdteagpstdskaaarhqhahvFTGPQTSA--KaYDLVLIWDDKMrgYRLERIASTFSLKYERSK 144
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap