Conserved Protein Domain Family
rad4

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TIGR00605: rad4 
DNA repair protein rad4
All proteins in this family for which functions are known are involved in targeting nucleotide excision repair to specific regions of the genome.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Statistics
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PSSM-Id: 273170
Aligned: 5 rows
Threshold Bit Score: 802.558
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q24595    195 SFEDKAGNAFDFrgllenanslertrdalskrnvtatpprsqaatmdvnallalgenqnYQSVEVEEREGNQRKKAGRga 274  fruit fly
AAB64689    1 MNEDLPKEYFEL-----------------------------------------------IRKALNEKEAEKAPLSRRR-- 31   baker's yeast
CAA46158   30 VRESTAFSRSLLp----------------------------------------------VKPVEIEIETPEQAKTRERs- 62   human
Q10445        --------------------------------------------------------------------------------      Schizosaccharomyc...
CAB09777      --------------------------------------------------------------------------------      fission yeast
Q24595    275 paapptldepsrlsktkstrikrhtktrpvstvvanagdtddsdfeevadadlssdqddgetpnisgdleirvgleglrp 354  fruit fly
AAB64689      --------------------------------------------------------------------------------      baker's yeast
CAA46158      --------------------------------------------------------------------------------      human
Q10445        --------------------------------------------------------------------------------      Schizosaccharomyc...
CAB09777      --------------------------------------------------------------------------------      fission yeast
Q24595    355 tkeqKTQHELEMaLKRRLNRDIKDRQILLHKVSLMCQIARslKYNRLLSESDSLMQatlKLLPSRNAYPTERGTELKYLQ 434  fruit fly
AAB64689   32 ----RVRRKNQP-LPDAKKKFKTGLNELPRESVVTVNLDS--SDDGVVTVPTDDSV---EEIQSSEEDYDSEEFEDVTDG 101  baker's yeast
CAA46158   63 ---eKIKLEFETyLRRAMKRFNKGVHEDTHKVHLLCLLANgfYRNNICSQPDLHAIg-lSIIPARFTRVLPRDVDTYYLS 138  human
Q10445      1 ---------------------------------MMSDEDNtySDDEEWLDLDLGLPn--NDIKTAPILNSSLLSSAVHGE 45   Schizosaccharomyc...
CAB09777    1 --mpPKRKASKNsVRGRKRRTRTNNLPLNPEVKEETVVSSthRQTRSQSKKPSLSSs--AEPPSESLDDNISALNSLQRS 76   fission yeast
Q24595    435 SFVTWFKTSIKLLspnlySAQSPATKEaiLEALLEQVKRKEARCKQDMIFIFIALARGMGMHCRLIVNLQpmPLRPAASD 514  fruit fly
AAB64689  102 NEVAGVEDISVEI-----KPSSKRNSD--ARRTSRNVCSNEERKRRKYFHMLYLVCLMVHGFIRNEWINS--KRLSRKLS 172  baker's yeast
CAA46158  139 NLVKWFIGTFTVN-----AELSASEQDnlQTTLERRFAIYSARDDEELVHIFLLILRALQLLTRLVLSLQpiPLKSATAK 213  human
Q10445     46 RLIQERPTHDFG--------DVEATVDrtVEKRSRLKITSVDRKIRLQIHQLHLLCLTYHLCTRNTWCDD---NRLNYLV 114  Schizosaccharomyc...
CAB09777   77 ASSSEKGSDEDNEk---lGSSEDDEFDddFDTWEQVDLSPNKQEDKKDLHIVTQHITPQLTKESKKGSSSa-MDKSIRLS 152  fission yeast
Q24595    515 LIpiklrpddknksqtveseresedeKPKKDKKAGKPAekesskstisKEAEKKNNAKKaeakPLSKSTTKGSETTKSGt 594  fruit fly
AAB64689  173 NL------------------------VPEKVFELLHPQ----------KDEELPLRSTR----KLLDGLKKCMELWQKH- 213  baker's yeast
CAA46158  214 GK------------------------KPSKERLTADPG----------GSSETSSQVLEnhtkPKTSKGTKQEETFAKGt 259  human
Q10445    115 KY------------------------IPPGIRVSLHPSs--------qKSQMIRNKTFLhglaGLVEVWKRKYKITTNGl 162  Schizosaccharomyc...
CAB09777  153 IH------------------------IMHFTCLLYHGSv--------rNRWLMNSLLLDglrdLLVEKQPSVVEAWVCS- 199  fission yeast
Q24595    595 vpkvkkelslssklvekskhqkaytssksdtsfdekpstsssskclkeeyselglskkllKPTLSSKLvlkSKNQSSFSs 674  fruit fly
AAB64689  214 ------------------------------------------------------------WKITKKYD---NEGLYMRT- 229  baker's yeast
CAA46158  260 -----------------------------------------------------------cRPSAKGKRn--KGGRKKRSk 278  human
Q10445    163 ------------------------------------------------------------RKPNYGLLqnnSLISESLS- 181  Schizosaccharomyc...
CAB09777  200 ------------------------------------------------------------SQTHEDLLkllNGLRMWWNk 219  fission yeast
Q24595    675 nksdtsfeenpstsssskslKEETAKLSSSKledkkvaspaetktkvqssllkrvttqnisesgdskkpkvapvdtfspv 754  fruit fly
AAB64689  230 --------------------WKEIEMSANNK------------------------------------------------- 240  baker's yeast
CAA46158  279 pssse----------edegpGDKQEKATQRRph----------------------------------------------- 301  human
Q10445    182 --------------------LEEFCKNSKLLsg----------------------------------------------- 194  Schizosaccharomyc...
CAB09777  220 --------------------SFKIESHGLRKl------------------------------------------------ 231  fission yeast
Q24595    755 agRTRRATVKpkteekpqvvgspviPKLMLSKVKQLNAKHSDTENASPAnkhlqeqrntretrsrskspkvlispsflkk 834  fruit fly
AAB64689  241 --RKFKTLKR---------------SDFLRAVSKGHGDPDISVQGFVAM------------------------------- 272  baker's yeast
CAA46158  302 -gRERRVASRvsykeesgsdeagsgSDFELSSGEASDPSDEDSEPGPPK------------------------------- 349  human
Q10445    195 -sRDYGTQLFasilrnlnvptrlvfSLQVLSFRFKGAINEASSHEIVPA------------------------------- 242  Schizosaccharomyc...
CAB09777  232 ---gYRTLKQg--------------FDIGFSPEIFHNFHEYQASLLSLK------------------------------- 263  fission yeast
Q24595    835 ksdgADSTSDPQKHQMAPETKARISpnflsealparqlrsrgqkasslaipqldggddvplpkkrpkleklknsqdsdev 914  fruit fly
AAB64689  273 ----LRACNVNARLIMSCQPPDFTN------------------------------------------------------- 293  baker's yeast
CAA46158  350 ----QRKAPAPQRTKAGSKSASRTHrg----------------------------------------------------- 372  human
Q10445    243 ----WSQQMENDSSSDISESAHITSrf----------------------------------------------------- 265  Schizosaccharomyc...
CAB09777  264 ----GSRDLAAQGFTALCRSLNLKAr------------------------------------------------------ 285  fission yeast
Q24595    915 fepakpVKKAPVLPKSVQNLRKDRRVMSTDDEGGSRLNRKTDaSDMWVEVWSDVeeqwICidlFK--GKLHCVDTIRKNA 992  fruit fly
AAB64689  294 ------MKIDTSLNGNNAYKDMVKYPIFWCEVWDKFSKKWIT-VDPVNLKTIEQ----VR---LHs-KLAPKGVACCERN 358  baker's yeast
CAA46158  373 -----sHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAgIDQWLEVFCEQeekwVCvdcVH--GVVGQPLTCYKYA 445  human
Q10445    266 -----rKRRKIIQPSFSNLSHLDASDIVTEDTKLKVIDSPKP--VFWVEAFNKAmqkwVCvdpFGd-ASVIGKYRRFEPA 337  Schizosaccharomyc...
CAB09777  286 ------LIFSLQPLTFSTASYDDWSPHILPEETSTSIDDDLRyPIFWTEIYDQSekkwIAvdaVVlnGVYTNDMTWFEPK 359  fission yeast
Q24595    993 t-------pGLAYVFAFQDDQSLKDVTARYCaSWST-TVRKARVEKAWLDET-IAPYLGRRTKRD-------ITEDDQLR 1056 fruit fly
AAB64689  359 ---------MLRYVIAYDRKYGCRDVTRRYA-QWMNsKVRKRRITKDDFGEKwFRKVITALHHRKrtk--idDYEDQYFF 426  baker's yeast
CAA46158  446 t-------kPMTYVVGIDSDGWVRDVTQRYDpVWMT-VTRKCRVDAEWWAET-LRPYQSPFMDRE-------KKEDLEFQ 509  human
Q10445    338 ssd---hlnQMTYVFAIEANGYVKDVTRKYClHYYK--ILKNRVEIFPFGKAwMNRIFSKIGKPRdfyndmdAIEDAELL 412  Schizosaccharomyc...
CAB09777  360 gayaeskhlRMGIVAAYDNDLYAKDVTLRYTdYQSSrLKKIRHVSFADKYFDfYKAIFGQLAKRNkd---aeDIYEEKEL 436  fission yeast
Q24595   1057 RIHSDKPLPKSISEFKDHPLYVLERHLLKFQGLYP--PDAPTLGFIRGEA-----VYSRDCVHLLHSREIWLKSARVVKL 1129 fruit fly
AAB64689  427 QRDESEGIPDSVQDLKNHPYYVLEQDIKQTQIVKPg-CKECGYLKVHGKVgkvlkVYAKRDIADLKSARQWYMNGRILKT 505  baker's yeast
CAA46158  510 AKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP--ETAAILGYCRGEA-----VYSRDCVHTLHSRDTWLKKARVVRL 582  human
Q10445    413 RLEQSEGIPRNIQDLKDHPLFVLERHLKKNQAIKTg-KSCGRINTKNGVEl----VYPRKYVSNGFSAEHWYRKGRIIKP 487  Schizosaccharomyc...
CAB09777  437 ESKVPIREPKSFADFKNHPEFVLIRHLRREEALLPnaKPVKTATFGNGKKatseeVYLRKDVVICKTPENYHKEGRVIKE 516  fission yeast
Q24595   1130 GEQPYKVVKar------pKWDRLTRTVIKDQ-PLEIFGYWQTQEYEPPTA-ENGIVPRNAYGNVELFKDCMLPKKTVHLR 1201 fruit fly
AAB64689  506 GSRCKKVIK---------RTVGRPKGEAEEE-DERLYSFEDTELYIPPLAsASGEITKNTFGNIEVFAPTMIPGNCCLVE 575  baker's yeast
CAA46158  583 GEVPYKMVKgfs---nraRKARLAEPQLREEnDLGLFGYWQTEEYQPPVA-VDGKVPRNEFGNVYLFLPSMMPIGCVQLN 658  human
Q10445    488 GAQPLKHVK----------NG--------DK-VLPLYDEEATQLYTPKPV-VANIVPKNAYGNIDLYVPSMLPYGAYHCR 547  Schizosaccharomyc...
CAB09777  517 GEQPRKMVKaravtisrkREHEFRVAETNEPvLQGLYSSDQTELYVPPPI-KDGIIPKNGYGNMDCFVESMIPKGAAHLP 595  fission yeast
Q24595   1202 LPGLMRICKKLNIDCANAVVGFDFHQG-ACHPMYDGFIVCEEFREVVTAAWEEDQQVQVLKEQEKYETRVYGNWKKLIKG 1280 fruit fly
AAB64689  576 NPVAIKAARFLGVEFAPAVTSFKFERGsTVKPVLSGIVVAKWLREAIETAIDGIEFIQEDDNRKEHLLGALESWNTLLLK 655  baker's yeast
CAA46158  659 LPNLHRVARKLDIDCVQAITGFDFHGG-YSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKG 737  human
Q10445    548 KRCALAAAKFLEIDYAKAVVGFDFQRK-YSKPKLEGVVVSKRYEEAIDLIAEEIDQEEKEAEARNVRKTCLLLWKRLITG 626  Schizosaccharomyc...
CAB09777  596 YRGIAKIAKKLNIDYADAVTGFEFRKH-RAIPVTTGIIVPEESAQMVYEEFLECEKIRIEKQQMKERKIIYGQWKHLLNA 674  fission yeast
Q24595   1281 LLIRERLKKKYNF 1293 fruit fly
AAB64689  656 LRIRSKLNSTYGK 668  baker's yeast
CAA46158  738 LLIRERLKRRYGP 750  human
Q10445    627 LRIRQRVFEEYG- 638  Schizosaccharomyces pombe 972h-
CAB09777  675 LRIRKRIEEQYA- 686  fission yeast
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