Conserved Protein Domain Family
PROF

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cl00123: PROF Superfamily 
Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the cytoskeleton - it may also promote actin polymerization. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway.
Links
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Taxonomy: root
PubMed: 7 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl00123
PSSM Id: 469622
Name: PROF
Created: 8-Feb-2008
Updated: 4-Oct-2023
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