7D0I


Conserved Protein Domain Family
ATG9

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pfam04109: ATG9 
Autophagy protein ATG9
In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles, and it is the sole transmembrane protein in the autophagosome-forming machinery. It colocalizes with Atg2 at the expanding edge of the isolation membrane where Atg2 receives phospholipids from the endoplasmic reticulum (ER). Atg9 is a lipid scramblase that translocates phospholipids between outer and inner leaflets of liposomes. Phospholipids delivered by Atg2 are translocated from the cytoplasmic to the luminal leaflet by Atg9, driving autophagosomal membrane expansion.
Statistics
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PSSM-Id: 461177
Aligned: 103 rows
Threshold Bit Score: 299.407
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7D0I_J        175 WRWANVENLDSFLQQVYTYYTGKGLSCIIVHRLFQILTVSFVIGFTTFITSCIDWPAV---------------------- 232  Schizosacchar...
EFC49244       87 REHLGVTNLDAFFQQVYVYFYEKGFWCMLVDRCLRLCTVFFMMIFSTFLFVFLNWYDMwhcqdvac-------------k 153 
ERM94913       61 LKAEPIADLDLFFERLYNYYCEKGLWCIITKWIVELLSVGFTIFFSGFFLLYVDWHSLskvkcgieavqsgkqqcdlfne 140 
XP_006355002   62 VSVEPISDLDLFFERLYNYYCEKGLWCIIIKWIFELLSLAFTIFFSGFFLLYVDWNGLrnakcgmdavesgikpcdlane 141 
XP_009141144   65 LNVQPIADLDLFFEKLYSYYRDKGLWCIIVKWAVELLSLGFIICFSGFFLLYVDWRGLknakcgmdavesgtkpcdlvke 144 
XP_006846402   56 LKVETVTDLDLFYSRVYSYYCEKGLWCIVTKWIVEILSLGFMICFSGFFLLFVDWHNLrnakcgvdaiesgskpcdlvke 135 
CBJ32769       25 DDWGAVENLDAFFTSMYKYYHRGGLLSIVSSGIAHLLILAFTVLFSTFLLSFVDWKALlscrdeet-------------c 91  
Q387F1         14 QNSGRIGDVHVFMKNLYRFWVYKGLWFSCLASLVDFLNSVVVFCLVVFLTTVFDWPVAa--------------------- 72   Trypanosoma b...
XP_002288788  127 EGWALVSDLDLFFSSLYNYYYMRGLGSIIGKGVVELISLFFTLWLSLVLFAYIDWSGLsscndee--------------- 191 
XP_009515079  111 DRYGNVPNLDAFLITLYNYYYHKGFWSIVVVELVSLVTGLFSVLLSSFMLGCVQWGPLlechrhpesggc-----kqeme 185  Phytophthora ...
7D0I_J        233 ------TP--HGSLAGVT--------KSQCIA-QMSPITYLV--LWLFLSFLLALWIYY--------------------- 272  Schizosacchar...
EFC49244      154 tvpvfrKNvwTMNAFHIV----------------------VLlfEFVVCFYWMYLLVKY--------------------- 190 
ERM94913      141 alfkhpLV--PFTFSRAI----------------------IVgyLGISSIYWVFCFLRF--------------------- 175 
XP_006355002  142 alhlhpLK--PLTLFKGT----------------------VLgyLGIFSVYWIFCFLRF--------------------- 176 
XP_009141144  145 aihehpLS--PFTLTTAI----------------------IVgyLALFSLYWLFCFLRF--------------------- 179 
XP_006846402  136 vvhskpFM--PFTLFKGI----------------------VAvyLGLFSIYWAFCFLRF--------------------- 170 
CBJ32769       92 hplsqyVT--TKALHSPN---------------LFHVLVWMY--MVLFLVYWAWSLLSF--------------------- 131 
Q387F1         73 -----aCD--EVSCGTVTlthhmrlpTERGAShVLLCLIL----LVSSAASATYEFLKFletcslqmetermvrvivdtg 141  Trypanosoma b...
XP_002288788  192 tckesfVE--GYLIENPF--------MEGRHSfLRNAWIVVY--CMLFSSYGVFCLIQF--------------------- 238 
XP_009515079  186 hyitcrAD--NNGVLGLV----------------------GAfyFAMFFVYWVSRAFQL--------------------- 220  Phytophthora ...
7D0I_J        273 -------LTDIPRLWQMREFYIHALKIATAD--MPTVSWQRVLYRLL-KLKN----VNALT--AEDGrvvslhnmkRLDA 336  Schizosacchar...
EFC49244      191 -------LRDLLGMLSIKHFFNTELNITEKD--IQTIQWVEVVEKII-EFQN----KKKIN--IIK----------NVDE 244 
ERM94913      176 -------FAQLRNTLEIRDFYYKSLKVTDNE--IQTTPWAVILDKVV-ELQS----SQQLC--VVK----------DLSA 229 
XP_006355002  177 -------FAQLRETLAVRQFYCRSLHVTDKE--IQTIPWASILERVV-QLQE----LQQLC--VVK----------NLSI 230 
XP_009141144  180 -------FAQLKDTLDFRHFYYNSLHVTDNE--ILTMPWETVLEKVV-QLQS----SQRLC--VVK----------DLSA 233 
XP_006846402  171 -------FAQLKGTIAVRNFYNNSLNINDRE--VQTISWSAVLEKVA-QVR---------CpsVVK----------DLSA 221 
CBJ32769      132 -------WSSLRDATDMHHLYTTRLRISRTD--LHTIEWSEVVSRFL-SLQNtglyRVAIY--TN-----------NVTA 188 
Q387F1        142 ytspfhrLAHIWRRMRVQSDGHEELPDHGLPf-IGNMAWGDFLDEVCaRIQR----DRSFGviEHK----------EFDS 206  Trypanosoma b...
XP_002288788  239 -------GHSVMASLESKMFLEEVLGVSDRDleVGRVEWGEIVERMS-DAQRdgrcRVAILpmDKQK---------HVDN 301 
XP_009515079  221 -------IGTLRDTREMEVFYKERLRIDERQ--VQTIAWDEVVTRVL-DLVNgvnaPVNMR---------------QLSS 275  Phytophthora ...
7D0I_J        337 -------------------YAIANRIMRKDNYFIALINNGIINIEL----PLLHRR-----------------ILTHTTE 376  Schizosacchar...
EFC49244      245 -------------------FDILNRIMRKENYLISFINKDVMNLTL----PFSQKT-----------------YLSEIIV 284 
ERM94913      230 -------------------HDMVMRIMRKENYLIGMLNKGVLALPIpswiPGAGPLvksqgn-----ggdnymILTEIFE 285 
XP_006355002  231 -------------------HDVVMRLMRKENYLIGMLNKGLLSLPIshwvPGAGPTiscgpn-----dvrsrlILPKTLE 286 
XP_009141144  234 -------------------HDIVMRLMRKENYLIGILNKGLLSFPIshwiPGAGPLvktapd-----gtqhhlVLTKTLE 289 
XP_006846402  222 -------------------HDIVMRIMRRENYLMAMLNKGVLAVPVpywvPGAGPAinsangg----grknrlILTKTLE 278 
CBJ32769      189 -------------------HDIASRIMRKENYLIAMLNKEILKLSLp--lPFFGSRgrgtlw-----attgrqYLTKSLE 242 
Q387F1        207 -------------------LRAVQALMVYENYFITFHQHGILERGA-----------------------------LKYAD 238  Trypanosoma b...
XP_002288788  302 nnnnnnnstiiedegptghLVVSQRIMRRENFMIAFFNKGLLDLTL----PQFPPWawplsawtrrpreekqvFFSKSIE 377 
XP_009515079  276 yklqidp------allsspHDFARRIMRRDNYLIAFMNHSLFQSKNl--lPTSLQFlst-----------shvMCSRNME 336  Phytophthora ...
7D0I_J        377 WNINWCIFNFVFDEQGQLRSAFRNPnsrkrlSEELRRRFIVAGFLNCLFAPIVAIYLVIHNFFRYFNEYHKNPGAL-STR 455  Schizosacchar...
EFC49244      285 YNLRI-VVDNMFDSEFKINEAFVKN------PNALRAFFVKLGLINLLLAPFLLIYIILYTSFKYLAELKNDPKKA-LGR 356 
ERM94913      286 WSLNCCILQSMFDRNFTIRRDFISN------PDSLKKRLMVVGLGIFLISPFLIIFMLVKFFLRHAEEFYKHPRTV-STR 358 
XP_006355002  287 WTLNWCILQSMFDRNFCIRRDFISD------PKTLKKRLMIVGVLMLLLSPFLVIFMLVYLFLRHAEQFYNHPSTA-SSR 359 
XP_009141144  290 WTLNWCILQSMFDCNFRVRRDFVSN------PETLKKRLFVVGLAMLLLSPFLVIFMLVYLFLRHAEQFYNHPSTA-SSR 362 
XP_006846402  279 WCLNWCILQNMFDRNFMIRRDFVNN------PFALRKKLMAFGFGMLLVSPFLAIFMLVYCFLRHAEQFYNHPSTA-SSR 351 
CBJ32769      243 WSMHFCVLNHMFSDKFTIRTQFLQD------VRALKARLVLVGLAHVVLLPFLLLFMVVYFFLQNAQEWHSSKSYL-GPR 315 
Q387F1        239 ENVIRMLIRSLFD-------EFSTLvrgkdhVTLLRWKVVKYLVVYALFYPFVVAHFLLRVLVKNAAMVRTDWGGY-MTK 310  Trypanosoma b...
XP_002288788  378 ASIYFCVLNYMYNNSKKIRPAFYGD------PSSLRRRFVLCGVAHAVFMPFLLFFVTLHFFMLNIYDWQSTKEYL-GPR 450 
XP_009515079  337 ANLNICLLDQMFDADLNLAPSVIHN------VDMLKKRFVIAGVLNFVLAPFILLYRLSRFFFLAAQEWQTNHVYYfGTR 410  Phytophthora ...
7D0I_J        456 RYTPLALWTFREYNELQHFFDERINDSYAAASHYVSQF--PDFNMIRLFKYISFILGSFTAILVIITVFDPELMVTFEIt 533  Schizosacchar...
EFC49244      357 RWSLYSTFKFREYHELAHEYERRLKEGYGPSIDYLNQF--PNVLLSIVANRAMFFISAIAGVIIVLSYLNNSLTLYLTV- 433 
ERM94913      359 TWSNLSKWILREYNEVDHLFKHRINAGFEQSAEYIKQF--PSPIVSLIAKFVSFVAGGFAAVLIIVALL-DESLLEAHV- 434 
XP_006355002  360 RWSNLSKWLFREFNEVDHLFKHRINSSAIHASDYLKQF--PSPILSIVAKFISFVSGGFAAVLIIIAFL-EESLLEGHI- 435 
XP_009141144  363 RWSNLSRWLFREFNEVDHLFKHRINSSAEHASQYLNQF--PSPIISIIAKFVSFVSGGFAAVLIIIAFL-EESLLEGHI- 438 
XP_006846402  352 RWSNLSKWLLREFNEVDHLFRHRLNTGSVHSVEYLKQF--PCPMVSLIAKFISFVAGGFAAVLIIIAFL-DESLLEAQL- 427 
CBJ32769      316 EWSPLARWTFREFNELQHFFEQRMSGSYVHANTFLMRF--PRPVLASLMRVTRFVSGSVVAVLLVMTFLEDSVLLHVKV- 392 
Q387F1        311 DWNKRALWTFSLYNEVPHVLSARIASGRQIVMEMICRLkpHSS----GKRFVCRVASGIILVLLSLSLVNTSLLVSGNL- 385  Trypanosoma b...
XP_002288788  451 EWSSVARWTFREFNELPHLFERRMEPSYKSASAYLDLFgkPSPLSIAIGRLLVFVSGSLGTLLLAFAAINDAILLHVKI- 529 
XP_009515079  411 RWSAYAIWRFREYNELPHVLDARMARSYSLADRYLGMF--PAGALAIIAGGVSFCASSLMAVLVLVSLLEESVLLETTL- 487  Phytophthora ...
7D0I_J        534 KDRSVLFYLGLFGSLIAVSRSIIP-DET-----------LVFAPEKALRRVITFTHYMPGWW--SDNMHSKAVQQEFCSL 599  Schizosacchar...
EFC49244      434 FNQNLLTWLTTLLLGWAFAKGFVI-DEH-----------AVFNPKQKLDDVCEILHHHDLKW--KGKGHHHDVRDDFVAH 499 
ERM94913      435 YGRNLFWFTVFFGSVTAISRSLVA-DEY-----------QVFDPEGAMSLVSQHTHYMPKKW--RGKEYTDKVRGEFEAL 500 
XP_006355002  436 FGRNLFWYAAVFGTITAISRAAIT-DEL-----------LVLDPQGAMSLVVQHTHFMPKRW--RGKENTEAVRTEFETL 501 
XP_009141144  439 FGRNLFWYAAVFGTITAISRAAIS-DEL-----------LVLDPVGTMAAVVQHTHYMPKRW--RGKENKDDVRLELETL 504 
XP_006846402  428 YGRNLLWFAAIFGTITAISRAVIP-DEL-----------HVFDPEGAMSIVVQHTHYMPKSW--RGKENSNHVRSEFEAL 493 
CBJ32769      393 WDRNLLWYIGVFSAIYAFSRSVSP-QASevptlqedsaeEV------MLKVAAHTHYMPEHW--LGKAHTVVVRAELLGL 463 
Q387F1        386 CGIPLLWWLTGSIAAFSVCNETPPvERE-------------YNYLPDLERLVKQLHYSQEEWnhSGESFYSAVTWDF--- 449  Trypanosoma b...
XP_002288788  530 GQWNLLWYAGIMGACFSVGKSLLP-KTTspyyg-harrnLVLDMNSELEKVATHTHYFPDAW--RGKGCDDRTKKSFSSM 605 
XP_009515079  488 MGHELLWYLTVSTGVFALSRSFTS-STSpfl--------ingDCEEAMMQVSAETHYFPKEW--RGQCHSFEVRDAFTVL 556  Phytophthora ...
7D0I_J        600 YSYRIVNLLWEILGILLTPVLLFFTFP-SCSQDIVDFFREHTINVEGVGYVCSYAVFQ 656  Schizosaccharomyces pombe 972h-
EFC49244      500 FIPSYSYFLNEIVSVFVTPIILIISLP-RSAERISSFVDQITVDYHGLGHICGHAAFK 556 
ERM94913      501 YQYIMKKLLEDMVSIFLTPYLLIFLVP-KCVDDILKFISDFTVDVEGVGHVCSFTLFD 557 
XP_006355002  502 FQYTGMMLLEEMTSIFLTPYLLLFVVP-KKVDDILRFIADFTVHVEGVGHVCSFSVFD 558 
XP_009141144  505 FQYTGMMLLEEIASIFITPFLLMFIVP-KRVDDILQFIRDFTVDIEGVGNVCSFSAFD 561 
XP_006846402  494 FQYTGLMLLEDMVSIFLTPYVLFFLLP-KKVDGILKFISDFTVDVEGVGHVCSLSVFD 550 
CBJ32769      464 FHYKAQLFLEELLAVLFAPVILCFSMP-SCAQEIVEFVTEHTVEVPGVGSVCSYSVFD 520 
Q387F1        450 LESRFSVIISDIARTLFMPCILLGLLFdGSLPALMECVQSESVRVDGLGSVAREAAFD 507  Trypanosoma brucei
XP_002288788  606 FQFKAQHFAMEVVSIIVAPLVLCFSLP-RCADDICRFVRDSKVEVPSAGDVIGYCTFD 662 
XP_009515079  557 FPYKAVLFAEECVSVLLAPYILCVSLP-RLSREILLFLRSHSLVHPSTGAVCRLAEFD 613  Phytophthora sojae
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