Conserved Protein Domain Family
BRI3BP
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pfam14965: BRI3BP 
Negative regulator of p53/TP53
This family of transmembrane proteins is found in eukaryotes. Proteins in this family are typically between 213 and 245 amino acids in length. It is found in various tissues, including the brain, liver and kidneys. It was first discovered as a functional unknown gene, murine brain I3 (BRI3). This protein is also known as HCCRBP-1 and it plays a role in tumourigenesis, as it binds to an oncogene, HCCR-1, and acts as a negative regulator of p53/TP53 tumour suppressor. BRI3BP induces tumourigenesis by activating protein kinase C (PKC) activity but decreasing the pro-apoptotic PKC-alpha and PKC-delta isoform levels. BRI3BP is over-expressed in many tumours.
Links
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Statistics
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PSSM-Id: 464410
Aligned: 13 rows
Threshold Bit Score: 156.325
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_003796088  52 TVNTFSQSVSSLFGEDNVRAAQK--------------------FLTRLTERFVLGVDMFMETLWKVWTELLDVLGLDVSN 111
Q28GF3        39 AATGFYQTVNNVFGEENVRAVQK--------------------FFSRLTERFVYGVDVLVETLWRIWTDLLEVLGIDASN 98  tropical clawed...
XP_006640166  38 AANGLYQTLSSIFGEDNIRALHK--------------------FFSKTTERFVYGVDAFLDTIWKIWTDLLDVLGIDSSN 97 
NP_001082804  38 AASGFYQTLSNVFGEENIRALYK--------------------FFSKTTERFVHGVDSLLDTLWKLWVDLLDVMGIDSSN 97 
XP_007229542  44 LCEDGHGFLVSLFGRQSVDSGLK--------------------TLREITTWALESTAGSLNILASYVTEVLGAAGITAN- 102
NP_001139031  44 LSEEAHSFLVSTIGEKRVDLSLK--------------------FLQSGVKWLSDAVASALNVAIRYITEILESAGIDAK- 102
XP_006010221  47 TGRAVLEGLEQVLGKELLQRALE--------------------FLTSCSEVIADGLSAGLRTLYRFANDGLRALGVEGER 106
XP_005046602 115 MGRTTWDTLENWVGPQLLQMVAE--------------------SLSTTLWIVSSGISAALTTLCGILGDLLAASSISGHR 174
XP_016851049  51 MSRAIRKTVEDLIGRDNFQILSE--------------------NLSSLLWIVSSGISSALLVVARVSGQFLTSFGLAGDH 110
XP_003993469  53 IGRSVRGTLEAWLGPETIHLVSE--------------------TLSQVMWAISSAISVAFFALSGIAAQLLNALGLDGDH 112
XP_005988983  34 AAQGLYRGLCSVFGEENIGALQR--------------------FFSKITDQFVCGMDVLVETLYRIWTDLLDVLGVDASN 93 
XP_010709077  60 LGHTTWASLEGCLGAEPLRLLAE--------------------SLLTALWLTASAISSGLAVLSSTVGDLLDACGLHGt- 118 turkey
CAG06272      38 TYREVQRYAESAMGIGVVRSAVEsavlflesllgqenvytmamFLETVIRFLAEGAASGLNVIAVYVAEILRVTGFDIA- 116 spotted green p...

XP_003796088 112 lsqYFSPASVANSPARALLLVGVV-LLAYWFLSLTLGFTFSILhlvfGRFFWIVRVVLFSMSCVYILHKYEGEPENAVLP 190
Q28GF3        99 lthYFSPAAVANNPTRVLMLVVAI-LLAYWFASLLLGFFFYLLhivfGRFFWLVRVSLFALSCIYILQKYEGEPEHAMIP 177 tropical clawed...
XP_006640166  98 ltyYFSQTALTSSPARTLLLVASV-VVAYWLLSLFLGGLFYLLqvafGRFFWLVRVVLFALSCLYILQKFEGDPERAVLP 176
NP_001082804  98 lthYFSPSSVSSSPARALLLVAAL-LVAYWFLSLFLSGFFYILhavfGRFFWLARVTLFALSCLYILQKFEGDPEKAVLP 176
XP_007229542 103 ----LPVKRITPEGVAFVTKWVLLaVLVYWILSLAVCFVSGIV----QRTLWLVKITVAIAMFGLILSDTGATAETTAMR 174
NP_001139031 103 ----LPFQKVTPEGVIFVTQWAILaVLAYWILSFILRLVVGAV----RQALWLLKLSFAVGTFGLILSDSGASAETTALR 174
XP_006010221 107 ---FTHFLNLSSQEVHTLLIWGAVaLIGYWLFSFLLHLILSVV----GRVFWLLKIGLFLSAFVYIITAYEDP-ARRATL 178
XP_005046602 175 ---LVRAAALAPREVQRVLLWAVAaLLGSWVLSRLRRLLLPLL--------HWLKLFLFLCAFLHVAASQESP-TVQAGM 242
XP_016851049 111 ---LTQFLKRSPDEVQTLLLWGLAaLIGYWLLSLVLSLLVAIL----SRIMWGLKVVLFVACFMFIVSSVPDR-SVQTLL 182
XP_003993469 113 ---LTQGLKLSPSQVQTFLLWGAGaLVVYWLLSLLLGLVLALL----GRILWGLKLVLFLAGFVALVRSVPDP-STRALL 184
XP_005988983  94 lthYFSPTAVTSNPTRAVLLVGAV-LLAYWFLALFIGVLFSLLhavfGRMFWIVRVILFALSCLYILQKHEGNPEQAVLP 172
XP_010709077 119 --wLAGSVALSPGAVQRVLLWGLLaLVGVHFLPWLLGLVVALL----RPVLHWLRLCAFLGAFLHVVAAEGSGLMVRAAM 192 turkey
CAG06272     117 ----VRLPLFTPEGVTAIAQWGLLaLFGYWVLSVLLHLLICVL----KRVFWVVKTVLALWLFGLIVTDKNATADTTAVR 188 spotted green p...

XP_003796088 191 LCFVVAVYFMTGPMGFYWRSNp---SNPNVEEKLEHLENQVRLLNIRLN 236
Q28GF3       178 LCFVVAVYFMTGPVGLYWRRS----SNNNLEDKIDHLDNQIRLLNIRLT 222 tropical clawed frog
XP_006640166 177 LCFVMAVYFMTGPVGSYWRKG-----GSSLEDKIDHLDGQIRLLNIRLS 220
NP_001082804 177 LCFIMAVYFMTGPVGAYWRKGg---GSGTLEEKIDQLDTQIRLLNIRLS 222
XP_007229542 175 LAGLMLACILLGIGPSPFKGD----TNTHMEVKVKVLERKVRELEKKSK 219
NP_001139031 175 LAGLACVCVLLGIGTASAKSD------AHLENKVKMLERRLKEMEKSKM 217
XP_006010221 179 LLVLLVVYVLLGRFC---SSSe--sEVHYLRDRVRSLEGEVNNINRNME 222
XP_005046602 243 LLGLWVLYALLGSL----VASp--dPSARLDAAVRNLEWKVEELRRRQK 285
XP_016851049 183 LLALLTLYVLLGWL----SGSh--nSGTRLEAKIRGLERQVEELQRRQR 225
XP_003993469 185 LLALLTLYALLSRL----TGTr--aSGAQLEAKVRGLERQVEELRWRQR 227
XP_005988983 173 LCFVVAVYFMTGPVALYRRRN-----SSTLEDKIDHLEGQIRILNIRLS 216
XP_010709077 193 LLGL-----WGLYVLXGGGRApppsPGAHLEAAVRSLEWKVEELRRRQQ 236 turkey
CAG06272     189 LWGLVLGCVLLNLL----KSDs--eKPCSTDTRLRNLEGRLRAVEKRKG 231 spotted green pufferfish
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