Conserved Protein Domain Family
mRING-HC-C3HC5_RNF26
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cd16788: mRING-HC-C3HC5_RNF26 
Modified RING finger, HC subclass (C3HC5-type), found in RING finger protein 26 (RNF26) and similar proteins
RNF26 is an E3 ubiquitin ligase that temporally regulates virus-triggered type I interferon induction by increasing the stability of Mediator of IRF3 activation, MITA, also known as STING, through K11-linked polyubiquitination of MITA after viral infection, and promoting the degradation of IRF3, another important component required for virus-triggered interferon induction. Although RNF26 substrates of ubiquitination remain unclear at present, RNF26 upregulation in gastric cancer might be implicated in carcinogenesis through dysregulation of growth regulators. RNF26 contains an N-terminal leucine zipper domain and a C-terminal modified C3HC5-type RING-HC finger, which is distinguished from typical C3HC4 RING-HC finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
Links
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Statistics
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PSSM-Id: 438442
Aligned: 11 rows
Threshold Bit Score: 102.493
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:modified RING-HC finger (C3HC5-type), extra conserved cysteine is not involved in Zn binding
  • Comment:The C3HC5-type RING finger is distinguished from typical C3HC4 RING-HC finger and C3H2C3 RING-H2 finger due to the existence of the additional cysteine residue in the middle portion of the RING finger domain.
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                #  #           # #   #  #              #  #           
Q9BY78        373 EQEERKKCVICQDQsKTVLLLPCRHLCLCQACTEILmrhp-vyhrNCPLCRRGILQTLNVY 432  human
EMP29010      443 EQEERKKCVICQDQsKTVLLLPCRHLCLCQQCTEILlqqa-iyqrNCPLCRQMILQTLDVY 502  green seaturtle
NP_001088692  384 QQEESKKCVICQDEnKTVLLLPCRHLCLCASCTQILlqqp-vhqrNCPLCRHMILQTLNVY 443  African clawed frog
CAF97502      374 EQEDRKKCVICQDAnKTVVLLPCRHLCLCRGCTSILlrqp-lyqhNCPLCRRMILDTMDVY 433  spotted green pufferfish
XP_005988169  405 EQEERKKCVICQDQtKTVLLLPCRHLCLCRSCTNILmaqp-myqhNCPLCRHMILQTLDVY 464  coelacanth
XP_007883812  396 EQEERKKCVICQDLsKTVLLLPCRHLCLCRGCTDILlqqp-vyqrNCPLCRQMILQTLDVY 455  elephant shark
EED91038     1793 MESDEHLCVVCEDAkKEVIILPCKHMCLCKKCANFDim------kLCPLCRSPVQDSLDVY 1847 Thalassiosira pseudonana CCMP1335
XP_013402763  365 SERDKRLCVVCQDQvKCVLILPCKHMCLCVHCAHQItaarmanrrICPLCRTRIEKVMNVY 425  Lingula anatina
EDO44234      449 RERDKTLCVICAEQpKQILIMPCRHMCLCSVCADTLlthw--nrrACPLCRCRIRSLIEGI 507  starlet sea anemone
KOF99787      347 RERDKRKCVVCQDHvKTVLILPCKHMCLCVQCANHIvrssppdrnVCPLCRTGIQKVMNIY 407  Octopus bimaculoides
ELU10311      377 SERDKRMCVVCVDQlKTVLILPCKHMCLCIDCAREIaqsrfterrVCPLCREPIETVMYIY 437  Capitella teleta

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