Conserved Protein Domain Family
HVSL

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pfam09749: HVSL 
Uncharacterized conserved protein
This entry is of proteins of approximately 300 residues conserved from plants to humans. It contains two conserved motifs, HxSL and FHVSL. The function is unknown.
Statistics
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PSSM-Id: 462880
Aligned: 94 rows
Threshold Bit Score: 134.717
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009154394  67 PPLP-PSFASLYATNV---RTFAADD----PSLHAGRKR------QIPHVAGNWPTHVFLEWTPSRDQVEILDGVID--R 130
CCD26032      17 PPIP-DSILNKYHIEPnlaKYDIEQT----SPSQNKSTKvmylrsSQRKLDQFWQAFIYLECKPTRGDRQFLSQIISttN 91 
Q6FJQ8        61 PPIP-SSVYDKYQIPPntdKYIERTD----NGMSLGAIKgs---dVFKRNIGKWSCFLYIEYRPSSTEREMISKTLS--Q 130 [Candida] glabrata
EDO19325      43 PTVP-STVLDKYYVSPnilKYTEEMSnlv--------------giKTGFRTGQFRSFIFLEWRPTSLQRQQLVKSIN--Q 105
XP_002173037  30 LSLP-EEFENKYRSSP-----RLLDD----PVFHQGRKR------TFAHVEGAWTTQSFIEVKLTRSLSSQLQQILKseI 93 
EPY51754      25 PKLP-DFIKDLYRKKR-----KTFDS----PNFHEGRKR------TKAHVEGLWAVQIYLDVDFDNSSKQKIQEIIA--- 85 
CCF52727      69 PPLEaDSLQRQDDDSP--------SDltpaPASNS----------SKKVARGDWLCYCFVDVPLDPSSSALIRDCHK--H 128
EXX60975      82 PPLP-SDFLQLYPDKKrkdYTKHIDD----PSKHQGRIR------SKPHVEGDWATHVYVDVTLTEEADHIINKIEE--L 148
ETN67715       3 KKLP-APALKLHSTTt---PSEEERK----PEDHEGRQR------SFPHERGIWASYVYIDYEGQEGLERMQQE------ 62 
XP_307963     14 PALP-SPALCIPGTTDd-tEPDEQQG----LSKHQGRTR------SFPHERGIWASYVFIDYGDSDGWLEMQNE------ 75  Anopheles gambi...
XP_009154394 131 VQQRNlgdiadsgggTPSVKLHSFLRS-----------------ELGALL---------PLHISLSAPLVLRTD-QKSAF 183
CCD26032      92 NNAKLhtsm---tnnGTALKFSPLYRS-----------------KLGSPQ---------NLHVTLTPNIPFASEaLRDSM 142
Q6FJQ8       131 FNQSWqk------kfPGTDIFEPLHYT-----------------TLGVPV---------PLHISLTKNIPFDSEtQRDRF 178 [Candida] glabrata
EDO19325     106 FNENLtk------tkGSNFRFDPLFIS-----------------SLGSPE---------PLHVSLSKSIVCESItQRNLF 153
XP_002173037  94 AIEERdd------gtPKSNDWVPLFFS-----------------ELGLAK---------PLHLTLSSMDCLDYE-SKESF 140
EPY51754      86 ----------------SQSEFRSLFTS-----------------EFGVVR---------SLHLSLSELFRIASD-ERKAV 122
CCF52727     129 LQEQL----------GTSHTLLDLIHS-------------------DASPgadpaeeagYLHVSLTRPFTVRSS-ERDEY 178
EXX60975     149 AKEVV---------------------SkdgikiisciedhqdnnSLNELDpngh-ceetKLHISLSKPLFLKYH-QIEHF 205
ETN67715      63 WNQEL---------------------Raag------------ikDFQPVG---------HLHLSLTKTFTIRHH-NIVPF 99 
XP_307963     76 CKTLL---------------------Ndas-----------ttvEFNPID---------RMHLSLTKTFTIRHH-NINPF 113 Anopheles gambi...
XP_009154394 184 QERFCDELRttrSSTTttdgcrsgnssrlglQPF--TVHVT-GLDWVANQDGSRWFLVLKLSRPD-NDELNTLLAVCNEV 259
CCD26032     143 LQVLSDKIN---KCKI---------------RPFvlEFESArACKLLRSVVNDKLFLALDVKEEikrNQLMEIHEIIDET 204
Q6FJQ8       179 YNILVPKVAqlrQH----------------------LVQFEdTLRFYGSPQTTSVFLGYNVAQSvkdNIIKDITDNIESA 236 [Candida] glabrata
EDO19325     154 YRELKKELQ---SVQI---------------QPF--TLTFTnKPLVLTAKQDSSMFLCLEVNRShrtKILKPIQDAISSA 213
XP_002173037 141 RVQWKQTLS---SAHF---------------QPF--SIQLG-KVLYLVNEQQTRGFLAWRIHFDe--HHLKPLCQKINDL 197
EPY51754     123 LTIWRRECQhlqHRAI--------------------RYKLQ-DPCLLFNDDRTRMFFVLKATFES-ADLLKKLLEISNNL 180
CCF52727     179 AKIAKAELQrlkETIGr--------------NSF--PFSFS-RIAYLNNDDASRHFMVLEVGSGr--DQFHKLSTALSKV 239
EXX60975     206 WNKLRNGF----LNWK----------------RF--SLSFA-NITSFSNDDKNRSFLAL-EVGKG-SNELKSMVDHVNKV 260
ETN67715     100 VGSLQELL----GVHR----------------RF--RLELD-GVGVYVNEERTRTFIGVRIAEVS-YPPLDRLVTELDEC 155
XP_307963    114 VANLREQL----AGLR----------------RF--RLEFS-GVQVYVNEERTRTFLGVRVAEES-YGALNALVTSLDEC 169 Anopheles gambi...
XP_009154394 260 A--------RR-FGLQPLYeedtkqeevqeqdgtkrghqhqqhqhqrqsregtqkkqrqkekreikagndKSHAFHISIA 330
CCD26032     205 L--------KK--VIPEYYsqswknra----------------------------------------kdfylnnaHMSLA 234
Q6FJQ8       237 LidsglsesDKmVTVPSFS--------------------------------------------------------HMSIA 260 [Candida] glabrata
EDO19325     214 L--------ETtFSNQSDIimn---------------------------------------------fqvSNEYLHMSIA 240
XP_002173037 198 N--------IS-FGMQPLR---------------------------------------------------PDFIPHISFC 217
EPY51754     181 M--------EK-YEGKELR---------------------------------------------------KDFLPHVSFA 200
CCF52727     240 L--------HRaFRAKAYY---------------------------------------------------EEARFHASTS 260
EXX60975     261 A--------ED-FRQKPFY---------------------------------------------------ENPRFHASIL 280
ETN67715     156 L--------LE-YKLPRYY---------------------------------------------------EDRSFHISLL 175
XP_307963    170 L--------RE-YKLPLYY---------------------------------------------------TDRAFHVSIL 189 Anopheles gambi...
XP_009154394 331 WALHnpnpdyfgnD------DHPVRMSQrstlah---leeegiNEQLRGL--EI--------AF--SSLKLKIGNSVIDI 389
CCD26032     235 ESNTvps-----------rmVKDFKKLQdllsynnnpkncndgDKETIQEenNL--------SFqiRTLKVDIDRQTLTI 295
Q6FJQ8       261 kls---------------naPKDILDKVgya----------dsnQMAKQIqdYVeispnqqpVFyvSSIKMNKNRELLTI 315 [Candida] glabrata
EDO19325     241 QMTNcppssanlkSssidwePFHGLDEI----------------------------------KVpcKEVKCLINRQLYSI 286
XP_002173037 218 WRKT---------NpkeceaWSSAISLYevpskfdnlvsaiedLLKSNNT------------NIpvKSVKLSTGGYLDTL 276
EPY51754     201 WAHA----------------KQGDFEAWescdrenlrfieletLLK------QFesamlksvSLenNSMKMVMGHKIHSV 258
CCF52727     261 CLEItktldddaePpelreaGEALGPRFsdivn---------------dvekKWgpqlrkhpPTwaARVGIQVANRITYV 325
EXX60975     281 WALG---------E-----------TSIdrslcda--iketeyfESITQH--VF--------NI--ENMVCKIGNKTFTL 326
ETN67715     176 WTLG---------Dqse-ivTS-RLPKLteqfe-------eiyeDEYTDL--TQ--------TI--RKLWFKCGNKLYPF 225
XP_307963    190 WCLG---------Drea-evRK-ELPALaavfe-------rvyeEEYCDI--SQ--------QV--KTLWFKCGNKSFHF 239 Anopheles gambi...
XP_009154394 390 P 390
CCD26032     296 P 296
Q6FJQ8       316 P 316 [Candida] glabrata
EDO19325     287 P 287
XP_002173037 277 E 277
EPY51754     259 T 259
CCF52727     326 D 326
EXX60975     327 D 327
ETN67715     226 Q 226
XP_307963    240 N 240 Anopheles gambiae str. PEST
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