Conserved Protein Domain Family
NARG2_C
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pfam10505: NARG2_C 
NMDA receptor-regulated gene protein 2 C-terminus
The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.
Links
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Statistics
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PSSM-Id: 463121
Aligned: 23 rows
Threshold Bit Score: 227.955
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ETN66051            404 RQALDKRQHeNRFYQLWKLTdeq----sdeEQAVLIDFRQDFYQTLRK--TRLFMNLSVKLEHQPEFGAEQMTKAELLHE 477 
XP_002606187        756 QDYTRPDKH-NVVYSLMSFG----------KLLLLVRSELPAVCRTTGghFKWFAHVRPKLEYQPDFGVEQLTPGEMCRE 824 
XP_008180842        233 NESVQDDYN-NYNYDKWMLKvsnvn-gvdkSFNLLVRNKPHGIQQQIKp-QNTPVVIIPKVEYQPEFGFEKVSEEQLVEY 309 
XP_001954923        384 SSGIVDSNS-NCALVSWILKsq------dhNFQMFSTLSIPAVRDSYGk-KLLGCHLI-KLENKPDCGCEIMTKYELLKA 454 
Q8IGQ6              104 PSDIEDGNC-NSALVSWTLRckgeg-ddcnDFQIFSTLSIPAVKDSSGk-EPLGCHFI-KLENKPDCGCEIMSKYELISA 179  fruit fly
EDV91144            382 VHPIKQARS-NGALVSWRLQtde----kddALLIYSSLAIAAVRDTLGe-HPLGCHLI-KLENKPDCGCEIMTKYELISA 454 
WGS:AANI:GJ23962-PA 384 VRPMPEAKS-NSALVSWRLRageadteaepALLMYSSLPIAAVRDAAAn-QMLGCHLI-KLENKPDCGCEIMTKYELLSA 460 
WGS:AAPU:GI23872-PA 388 APVVTEMKT-NCALVSWRLRaae----stkSLSIYSSLSVAAVRDAAAk-QLLGCHLI-KLESKPECGCEIMTKYEMLSI 460 
EDS41823            376 RKPSEPVQK-NVSLQLWNLQdg------deQYRFLVRTRTDCYESLRK--VKFYINISIKLEYQTEFGAEQMTKSELIRE 446 
EFX71206            521 QEYIQPKRNeNLTYRTWDLKvn------ekSVRLLVRSSVDTAIVKPDd-SLKTFLMVPKTEYQPWYGAECYSPREINEQ 593 

ETN66051            478 WARQLLR-PNSKTLRIRLDPVTHRMISSHYLELRDIEEELLrlyGV--KPRHLITSMWGTLRRL--QLFPVGSYLLHRDE 552 
XP_002606187        825 WISTYIMpPESRLIRVRINAFTSEVMLVEQLKHNQILDHRV---HF--SPGTAMKMLLSILEKV--QSLPPGHFLLTHNP 897 
XP_008180842        310 WLDTSFRcPKTKLAL--VSVQHDMDLMQVKWTIEEVESLSS---NG--KDQMYLQRLYLTLEKL--TQLGKGEYVLLHNP 380 
XP_001954923        455 WLQIKLL-QAESGHCTRISLRDFDPVLEEKLTLASLEQQLHdyyNT--SMPQLLSNLFEFLKIF--HTVPVGDYLLRYSP 529 
Q8IGQ6              180 WVQLKLM-RAEMGHCTRISLRDFEPMLEEKLTLISLEQQLHdyyNT--SMPQLLSNLCEFLKLL--DTVPAGDYLLRYSP 254  fruit fly
EDV91144            455 WLQLKLL-QANVGHCSRISLRDFAPLLEQQLKLEALEEQLYeyyHT--SMPQQLCQLHEFLKLL--RTVAPGEYLLRYTT 529 
WGS:AANI:GJ23962-PA 461 WLQLKLL-QTDIGHCSRISLQDLAPLLEEPLTLGALEQQLHeyyHI--SMPQQLSQLREFLKLL--RSVTPGRYLLRYTA 535 
WGS:AAPU:GI23872-PA 461 WLQLQLL-QSNVGHCSRISLQDMQPLLEQKVTLSTLAQQLHecyNI--NVAQLLSQLAEFLKML--SSISPGEYLLRYTS 535 
EDS41823            447 WTRQRLR-PNSRTLRLRINASNHIILSHHYLELKDIEEELKrlyDI--EPQNLLTNLWQTLRLI--MQFPPGEHLLQHDT 521 
EFX71206            594 WMDLYLR-PECNLLRMRLDAYSGHLLVHEQKDVACLEAENSfqyGTqnKPANCLKNVWAVLSSLcdLNLSPGKFLLRHGF 672 

ETN66051            553 RTVqGWSVYTEVgrergqQLNPNAVVYDLRTRLHAIEYDLPPLEq----YDWIPIDKCFITQVHREGSILPCSFPH 624 
XP_002606187        898 GDV-HICIYQGLd-----SSAAKKGAYDLHSAHQQAAATPTTETr----PPWVPLDPSIILPQHWQNGRVPGTFEP 963 
XP_008180842        381 KKPfHVDVYQSS----------VYGGFNLLNMYFVLQQTEVSDS-----LVWNPIDREILCPIHNYFKVAPCMFRP 441 
XP_001954923        530 K-------YKDKfllcttTKQASTQSFQLHQVLKD--AVPSDQNfl-sqSSYLPISATLCGRMHEELQLVPCSFPA 595 
Q8IGQ6              255 K-------YKDKfllcivTKEATPQSFQLHQLLTE--SIPSDQAfl-tqSSYLPISPTLCGRLHEELHLLPCAFPA 320  fruit fly
EDV91144            530 K-------YKDKfllcrpSLEATAQSFQLHDLLMS--KPPTDINfltqsNSYLPISTKLCSRLHEQLQLLPCAFPA 596 
WGS:AANI:GJ23962-PA 536 K-------YKDKfllcqpTPEPTPNSFKLYDLLAG--TSPNDINfltqaASYLPISPKLCSRLHEQLQLLPCSFPV 602 
WGS:AAPU:GI23872-PA 536 K-------YKDMfllcqpTADDTSMSFKLHELLMGT-SSPNNIDfltqsSTYLPITPLLCSRLHEQLQLLPCAFPA 603 
EDS41823            522 KNPeTVMILSQS---------STTFTLDLHALYSNVEYERCALEe----YDWVPIDATVITKLHREHTLLPGTFPH 584 
EFX71206            673 HDGiCIQVWEST--------DKESSSLDLHQIYAEIDTTANAVRdv--gENWVALDPYAVLPIQRALFRPPLTFEP 738
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