Conserved Protein Domain Family
Inhibitor_Mig-6
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pfam11555: Inhibitor_Mig-6 
EGFR receptor inhibitor Mig-6
When the kinase domain of EGFR binds to segment one of Mitogen induced gene 6 (Mig-6), EGFR becomes inactive due to the conformation it adopts which is Src/CDK like. The binding of the two proteins prevents EGFR acting as a cyclin-like activator for other kinase domains.The structure of Mig-6(1) consists of alpha helices-G and -H with a polar surface and hydrophobic residues for interactions with EGFR. A critical step for the activation of EGFR is the formation of an asymmetric dimer involving the kinase domains of the protein. Since Mig-6 binds to the kinase domain it blocks this process and EGFR becomes inactive.
Links
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Statistics
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PSSM-Id: 463294
Aligned: 8 rows
Threshold Bit Score: 109.32
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004567249  883 RPPQIPPRDPLSQPGSRTPSPMG-LVVGSPQQrlysvspntmqaaittcPPTHT-----------------YSSYLSTSP 944 
XP_023190785  856 RPPQIPPRDPLSQPNSRTPSPNC-AVVGSLQQricsv-------spsthQASHS-----------------YSSHLSTSP 910 
XP_013965731  776 SPPRVPPREPLSPQGSRTPSPLV-PPGGS------------------------P-----------------LPPRLSSSP 813 
XP_012818066  832 RPPLLPPRDPLSQPTSRTPSPMA-FQVGSPQQrs-------------nlCSPLS-----------------IGTYLSTSP 880 
XP_026710781  679 RPPQIPPRDPLSQPTSRTPSPMA-LQVGSPQQ-----------------RAT-------------------LCSCLSTSP 721 
XP_022534393  801 HPPQIPPRDPLSQPGSRTPSPMG-LHVGSHCS-----------------PASIY-----------------GSSYLSSSP 845 
CAF97625      813 HPPQVPPREPLSQPGSRTPSPRG-LVVGS-----------------------PHqrvysvsptaaqaplssYSCYLSTSP 868  spotted green...
AWP04485      913 RPPQIPPRDPLSQPGSRTPSPMgllAPLTSC------------------PPTHT-----------------YGSYLSTSP 957  turbot

XP_004567249  945 GKLMPTTHSFASDPKYAAPKVIQAQVQGK 973 
XP_023190785  911 GKPMPTTHSFASDPKYAAPKVIQAQGRDN 939 
XP_013965731  814 GKTMPTTQSFASDPKYATPQVIQAPGPRA 842 
XP_012818066  881 GKLMPTTQSFASDPKYATPKVIQAQGKDH 909 
XP_026710781  722 GKPMPTTQSFALDPKYATPKVIQAQGKDC 750 
XP_022534393  846 GKLMPTTQSFASDPKYAAPKVILAQGKDK 874 
CAF97625      869 GKLMATTHSFASDPNYAAAKVSQAQGKEA 897  spotted green pufferfish
AWP04485      958 GKLMPTTHSFASDPKYAAPKVIQAQGkdp 986  turbot
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