Conserved Protein Domain Family
TFP_LU_ECD_PSCA
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cd23573: TFP_LU_ECD_PSCA 
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins
PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467103
Aligned: 9 rows
Threshold Bit Score: 89.8118
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O43653        10 TALLCYSCKaqvsneDCLQVe-NCTqlGEQCWTARIRAv-gLLTVISKGCSLnCVDDSQDYyVGKKNITCCDTDLCNASG 87  human
POI26763      26 SSLQCYSCKsklsnsNCQERi-NCNe-NEMCKTDVIRVi-gFFSIISKGCEAsCQEDYQDFkVGNRNVSCCSSDLCNVNA 102 Chinese bamboo-...
XP_015277305   6 GSLKCYTCTlqvsnaKCQREt-DCDgnAKACRTDMLRAv-gLLSVITKECSLsCEGVYKDYtVAKRNISCCDADLCNRSG 83  Gekko japonicus
XP_026571810  34 GSLWCYTCRtqlktdNCKRAv-FCKekAKVCKTDVISLm-gLLHIISKQCASsCTTYHKDIaILKRNISCCTTDLCNVDD 111 Pseudonaja text...
TFK01565      26 GSLKCYTCKsqlsnsNCQTEs-PCAndSQACKTDVINIv-gLFNVINKECAAsCDPRYQDFtVGKQNVTCCSTDLCNRSG 103 big-headed turtle
XP_019376081  19 FALTCYTCPaktnnaDCLTPt-ACPanFTECKTEVYVPvlgGWKVITKECSSsCTNSTANLfVFKKNTLCCSTDKCNHNS 97  Gharial
XP_025025680  19 GSLRCYTCNtqfnidNCKTAv-ICKeqARACKTDVINTv-gFLNIISKECVSsCNMYYKDFfLGKRNISCCSTDLCNAGG 96  Burmese python
XP_028919540  19 GSLQCYKCTgqtnnkNCQTVq-PCRheEKVCKTELTTAa-gLVRFITKSCVEsCQEETNNYhVGFRNVTCCRSDLCNVNG 96  platypus
KFU85552       2 SSLQCYSCSfqlsdsKCNTEdtICRa-NQTCKTDVIKVa--FLKIISKGCDS-CSPTFQDYgVSSRNVTCCTSDKCNVNA 77  chimney swift
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