Conserved Protein Domain Family
CECR6_TMEM121

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pfam14997: CECR6_TMEM121 
CECR6/TMEM121 family
This family includes Cat eye syndrome critical region protein 6, a protein which has been identified in a screen for candidate genes for the developmental disorder Cat Eye Syndrome (CES). It also includes the TMEM121 transmembrane proteins. The function of this family is unknown.
Statistics
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PSSM-Id: 464432
Aligned: 14 rows
Threshold Bit Score: 182.095
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7RFR8        59 AFSAIkggtCWLLY-VYSIAIKVIFMYFFAfSDNdileNTRTDY-YNKSIVFILLSLStLIYTALSVKSYKQLYPDEnti 136 Plasmodium yoel...
XP_001636436  82 AFAYL----AWFVY-CLHLVPQIATLFRLK-ANE----LDEKTMvFGPNMLKMCLCIT-PVLFLFLIFAHHDARPYS--- 147
EDO33715     101 PYAFI----AWFAYtAITLVPEIVVIFKNF-ADE----LEDVKI-LGQNVLKVALCIT-PMLFLLLVNSHHNTKQSA--- 166
EEB19155     119 PLIYV----SWAFY-VVLLLSKIAVIFTSEiPEH----LNTKNV-AGPQLLKVGIALS-GVIFLILVEGHNWSEPGS--- 184
EFX84980     106 PLCYL----AWICY-ATCLVTKVAFIFKSEiINT----LKPQDI-FGPQLLKFTISSS-TIVFILLVAAHHDSEKDS--- 171
EFO87068     189 KYACF----AWGVY-ALVLIFKIGTCFRLFyEDIpptpLDNNDKlFDDFLFKAGLSLS-VLIFLFIFESHHYTPLVS--- 259
CAF96745     177 TYAYL----AWLIY-VISCTPKVVLILETSiLD-----LITLKVpFGLTGFKVVVLLSvPLLFCLISAIVE--DPNG--- 241
XP_005164731 167 TFAYL----AWLIY-VIASTPKVVLVLETSiLD-----LIALKVpFGVTGFKITMLLCaPLLYCLINSIIE--DPNG--- 231
EFB24297      73 GYAMT----LWFLY-VFVLEIKLYFIFQNYkAAR----RGAADP-VARKALTLLLSVCvPGLFLLLVALDRMEYVRTf-- 140
NP_001138269  73 GYAMI----LWFLY-IFVLEIKLYFVFQNCkADR----K-SLET-VARKALTLLLSICvPGLYLVLVALDSMEYVRTf-- 139
Q7RFR8       137 sNEKIFHKDLILHVVIDLFDIFELLFTLLRLPHiiestnFWIKIIGGVLISFSVYLngySFPIISIVAEKNSKN--LDLG 214 Plasmodium yoel...
XP_001636436 148 -KRKLYLEKICGSVTLDLFDSVEMLEYLFDKEH------LNLGIEISILVFACVNI---FLPSLALYELKHNKFheSGQV 217
EDO33715     167 --RKWYIDKLTGGVTLDLMDSIDILEILFLKDAiv---dLPVALENIIIAFACINF---FLPTLALLELSVNKF--DGQV 236
EEB19155     185 -PRYLYVSSICTKTGIEILDSVSFLSILLSDSGnnlpdtLTPTFISGIVAIAGVNF---LLPVLILYKLSLGEH--HNKR 258
EFX84980     172 -QRALAIKSMCTNTAFELLDSVAFLSILIIKEShl---aVTYDFENFVLVFACINF---FLPTIALYQYSLSDF--GQLE 242
EFO87068     260 -VRQVYISYLVAAICLDLIDNIYFLDLLWQAskd--kwnLELWLEWTILVVACINF---FMPTFALAKLRYAKV---PRF 330
CAF96745     242 -PSRHRSQSCFLSTCLDLLDAFTLVEMMLRGEi------pTVYLKYAVMSVYWVTL---AVPVVWLYELTVSEL------ 305
XP_005164731 232 -ATRFHSQGCFVSTCLDILDSFILVEVLLKNEi------pNVYLRYTVISVYFIAL---GVPVVWLYELTASEM------ 295
EFB24297     141 -RKREDLRGRLFWVALDLLDLLDMQANLWEPPRt----gLPLWAEGLTFFYCYMLLl--VLPCVALSEVSMQGE------ 207
NP_001138269 140 -RRKEDMRGRLFWVALDLLDLLDMQANLWEPQRt----gLPIWAEGLMFFYCYILLl--ILPCVSLSEISVQGD------ 206
Q7RFR8       215 DIYFCKKH-SAVIGIILIDIPFMILRFylLVF-------YFSNIHFQPLLIKNICFIPIKCITIKRC 273 Plasmodium yoelii yoelii
XP_001636436 218 SPVSFKII-YVCGFLLFVNVPFLVIRL--ILW-------HSFNLDISVLLAKNALGVILGLIEIFEF 274
EDO33715     237 RSVSFQIL-YSLSYIGLVNVPFWIIRV--YIW-------WVFSQDVSVFIAKNIIMTVIYSMDIYES 293
EEB19155     259 LPVPLTVL-HNLLHVFSVDMPYFAIRL--LLW-------VRHNHNTSIFIMKNAFGMLMAVRNIYPD 315
EFX84980     243 KPLDLNGV-YHLSHMSLVNVPYLAVRV--YLW-------SGYGSDISLFVMKNVIGILWHLKDIVPD 299
EFO87068     331 L-LVSEKL-WAFLYVLLVNGPFLGLRI--YLYivlevqqHGKKYDPSLFGVKNIAMIYIALRELWTR 393
CAF96745     306 ---GCRRLcFRFLSALLVNAPLLVIRC--LLV-------FVHNANVSAFLFKNVFFSACQLLELLEQ 360
XP_005164731 296 ---NCRWVwARFFTGVLLNAPLLVVRC--FLV-------FVYKTPVSVFMFKNIFFLGCKCLELVEQ 350
EFB24297     208 HIAPQKMMlYPVLSLATVNVVAVLARAanMAL-------FRDSRVSAIFVGKNVVALATKACTFLEY 267
NP_001138269 207 HISPQKMMlYPLLSLVTINIVTILIRGvnMVL-------FQDSRVSTIFVGKNVVAIATKACTFLEY 266
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