2AS0,2CWW,4DMG


Conserved Protein Domain Family
RlmK

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COG1092: RlmK 
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification
Statistics
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PSSM-Id: 440709
Aligned: 655 rows
Threshold Bit Score: 204.645
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
COG1092 is classified as a model that may span more than one domain.
COG1092 is the only member of the superfamily cl34101
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2AS0_A         4 VVVDAQAARAIGKGAXIVFKKGVVRV-EGDIKPG-DIVEVYTRGGKF-LGKGFANPN-SNIXVRIVTKDKD--V-EINk- 75 
SQG00323       1 ---------------------------------------M---------------------------------------- 1  
WP_041755717   1 ---------------------------------------M---------------------------------------- 1  
NP_718041        --------------------------------------------------------------------------------    
WP_014245119  13 VKLHPATLKHAKKGHPWVTEDSYTKEfP-R-KQNl-LIG-KNPKGDEkLFLL-HDPThKKVKARIWEIGTElpEsPNGfl 87 
WP_075098054   1 ---------------------------------------M---------------------------------------- 1  
WP_046008811   1 ---------------------------------------M---------------------------------------- 1  
WP_087463313   3 V------------------------------------------------------------------------------- 3  
WP_102243103   8 VNLHPASCKYLKLGHPWITEDTYTKRfP---KEAfFLIGV-DEKNRQdVALLINDPLhKTVKARLWSLNKA--EwTLDfk 81 
WP_111334376 320 Vs-DRSLEILSRKGHPWVLEDRDTGR-RDTIDPG-TIVHLMDTRGRP-GPWALVEGP-GQLAARLWSHDSG--AaK-Nfe 391
2AS0_A        76 DLFKRRIKKANEYRKKVLk-----YTNVYRXVYGEADYLPGLIVDRFNDIASLQISSAGX----ERFK-LDVAEAIXEVe 145
SQG00323       2 STLIQALSVALDNRQPLLaqlhqqGTDCYRLFHGSQEGASGLTIDRYGPQLLVQSFHTRL----ERDAlLELHAAVNAH- 76 
WP_041755717   2 PSPDQALRAAFDRRRPLLdqlhqqGTDCYRLFHGSQEGAAGLTVDRYGPQLMVQSFHQTL----AADAlLRIHELAMDA- 76 
NP_718041      1 MSIQTLLSTALAKRHGFFlqaeqdHTDCFRVFHGTVEGISGLNVDRYGDTWLVQSFHQTL----TVEElAEIVAVLTQE- 75 
WP_014245119  88 RSFNHRLEESFLKRVSARek---yQRDNFYLCFAEADGIPGLMIQKFGNVALIQIYSDFWfffkNDIR-RIVKAHCASH- 162
WP_075098054   2 VSLEDLVARAIDRRGALLsrmereETDCVRLFHGATEGAPGLAIDRYGPVLLAQTWRDPL----EPGAlERVHATVTRA- 76 
WP_046008811   2 NELKTLISQAWQNRSDLKaqwlaeNTDCYRIFHGTNEGLPGTTLDRYGPLLILQTFHQSV----TDDElTQVHEFAAKE- 76 
WP_087463313   4 PELLQAVESAWHRRSSFMarcaqeQTSCYRLFHGSAEGGAGVTIDRYAETVLVQTFHQSL----TDAElEGLELFYKGE- 78 
WP_102243103  82 DVLKSRMKAAIDKRRALMk-----ERENIFLINGESDELPGLLIQLLKDEVMIQYYALFW----KDKE-DLVLENLKEN- 150
WP_111334376 392 EEIDLRVDEALAARSRLTrd--taETDLFRLVHAEADGFPGLQIDRVGPLLRATLTGATA----LGFR-DRVYQNILDF- 463
2AS0_A       146 PGI---ETV-F-EKN----TGRS-R-RREGLPEI-ERVLL-G----K-EK-YRTIIQEGRAKFIVD--XRGQKTGFFLDQ 204
SQG00323      77 L-GlnlLLV-YnDRS----QGNS-RiD-REDSVY-KA---------DpAAlQDLIGHEWGLNYRVRgrHAGQDPLLFLDL 138
WP_041755717  77 L-ElplQLV-YnDRS----QGNS-RiD-RSHAAY-QP---------DaAAlADQVGHEWGLAYRVRgrHDGQDPLLFLDL 138
NP_718041     76 Md---lPVV-YnDRS----AGHS-RvL-NALSPE-LD---------DiAC-AELVMQENGIKFTTKlrHEGQDPLLFLDM 134
WP_014245119 163 F-Pe-vDKFiFqQRK----TSDA-V-NFENLE--------------K-KL-TEITIQEFGINYHLRf-DYRYDIGIYSDM 217
WP_075098054  77 L-GidlAPC-WnHR------GPS-RrE-GVRGSD-TS---------DpRL-HAPEGRELGAKYDVRprHRGQDPLLFLDL 135
WP_046008811  77 F-Pd-vHFV-YnDRS----GNNS-RiQ--DSSVE-IH---------ElDG-MAMEASELGVKYRVKgrHQGQDPWLFLDL 135
WP_087463313  79 L-Pl-cTLI-YnDRS----ATNS-RyQ-NTLSPS-LE---------TfAK-TRQVGLELGMKVACQarHQGQDPLLFLDL 138
WP_102243103 151 L-Ph-lQEI-W-VQE------RNfD---QAKS---IRSIN-G----K-DS-SEFTLTEFGLNYRIKi-NQHYDFGIYSDM 206
WP_111334376 464 -NP---EIM-I-LEVehfeDIRA-E-KTPGPGDRlARVIErGanyaR-EG-ERVVGLEDGLKYWCEp-WEGIDVGFFADQ 532
2AS0_A       205 RENRLALEKWVQpGDRVLDVFTYTGGFAIHAAIAGADEVIGIDKSPRAIETAKENAKLN-GVE-DRXK-FIVGSAFEEXE 281
SQG00323     139 RNTRGWVKQHSK-GKSVLNLFAYTCGVGLSAAAGGASEVCNLDFAEGNLAVGRENGALN-PEL-PGMS-FIQSDYFPAIR 214
WP_041755717 139 RNARGWVKQHSA-GKSVLNLFSYTCGVGLCAAAGGARDVWNLDFAERNLAVGRENAALN-PGL-APMR-FVRSDYFPAIR 214
NP_718041    135 RIGREYVRAHSQ-DKTVLNLFSYTCGIGTAAAMGGAERVVNVDFSSFALAAGRTNAELN-QVS-EVCE-FVQSDAFPALR 210
WP_014245119 218 SAIRKKLTNEFRnAKSVLNLYSYTGAFSLFALSKGATDVHSVDLSKDYITWLEKNIELNpQLNsSHHE-SKITSVEKALK 296
WP_075098054 136 RVGRRWVRAESA-GRSVLNLFSYTCGVGVVAALGGAREVWNVDFAASALEVGRDNAQRN-EIR---FE-TIEDDVIPVVR 209
WP_046008811 136 RAGRRYVKANSE-GKTVLNLFSYTCGIGIAAGVGGAKRVVNVDFAESSLAVGMENAKLN-NLK--QVE-FIHSDVFPAIK 210
WP_087463313 139 RVVRRYLQASSA-GKSVLNTFAYTCGAGVAAALGGAKQVINVDFAESSLAVGKENAALN-DLStDVIK-FVQDDYFAVVR 215
WP_102243103 207 SAIRKNMRPYLEgQKSLLNLFSYTGAFSVYCMGMGFDKVTSVDLSSKYLAWLDENIALNpSLNsSHHT-SLCMPSERAMD 285
WP_111334376 533 RENRRKMRKIAKsGQRWLNLFCHTGAFSVALTALGC-EVVSVDLSKRYLEWLEDNLRLN-HISg-KLNySVADDARAYLS 609
2AS0_A       282 -KLQ-------K----------KGEKFDIVVLDPPAFVQHEKDLKAGLRAYFNVNFAGL-NLVK-DGGILVTCSCSQHVD 341
SQG00323     215 -QLAglpitqrRghklpdyvklDQRQYDLVLLDPPAWAKSAFGTVDLLRDYQSLLKPAL-LTTA-DNGVLICCNNLAKVS 291
WP_041755717 215 -QLAglpvasrRgralpdyprlEQRQFDLVLLDPPAWARSAFGTVDLLRDYQSLLKPAL-LTTA-EGGVLICCNNLAKVP 291
NP_718041    211 -QLAglsvggrRnhklpsypklAQTQFDLVFLDPPRYAKSAFGIVDLVNDYQGLFKPAL-LSTK-TGGTIVCCNNVAKVD 287
WP_014245119 297 -SYA-------D----------EGKKFDLIICDPPSFSSDGRKSQSALKSYDKLIP-MIeSCLS-DEGKAVVFLNTHHIL 356
WP_075098054 210 -QLAglpvkgrAtrrg--ftkrEARTFDVVVLDPPRWARTPFGAIDVVRDYPSLFKPAV-LACA-PGGVVLATNHVPTVE 284
WP_046008811 211 -QFAnmpiavrRgkklpkypkhKPEQFDLVFLDPPRWAKSAFGNVDLIRDYQSLFKPSL-LATK-SGGQLICCNNVAQVD 287
WP_087463313 216 -QFAglnvggrRgqnrgkirkrPVQQFDLVLLDPPRWAKSPFGVVDLVNDYASVFKPAL-LSTA-EGGVLICTNNVAKVA 292
WP_102243103 286 -KLI-------S----------EGAKYEVIVCDPPSASSDGNKVSNAIKSYETLLPQML-ELLDtEKGKIFAFLNTHAIS 346
WP_111334376 610 gEAK-------R----------RDEQFDGIIVDPPTAAAGSSGFWSVKKDYEDLLVECF-KRLA-KGGVLLVCRNEKRPS 670
2AS0_A       342 LQXFKDXIIAAGAKAGKFLKX-L-EpYRTQAPDHPILXASKDTEYLKCLFLYVED 394
SQG00323     292 MDDWREQVLRCATKTGRPVRD-W-Q-IMPPAEDFPSMDNq---PPLKTLILQL-- 338
WP_041755717 292 MDEWRTQVLRCADKAGRPVRE-W-Q-VLTPAADFPSHDGl---PPLKTLILRL-- 338
NP_718041    288 RRDWFDSLVRCVEKQGRSVTE-Y-T-WLDPHEDFPSFDDn---HPLKIVALTLN- 335
WP_014245119 357 RKKFNERIEQLASKSGMR----VaK-ALRMEEDCVTLSGFPEGDYLKGLLLSRK- 405
WP_075098054 285 RDEWHAVLRRTAEKAGRGIAR-I-D-ELVPEEDFPSFDEr---PPLKIAVVRLA- 332
WP_046008811 288 RDEWLESLKRCAIKAGRPLKS-I-E-MLLPEADFPSPDGn---PPLKVAICQL-- 334
WP_087463313 293 SGQWLEQLQRAAQKAGRPAKQ-L-Q-LLTPEEDFPSFDDq---PPLKVAVLEV-- 339
WP_102243103 347 WNKFEEKLKAIVDSSKFKNQVvIgK-RFKLNEDCLPLKGFHEGDYLKGFLIEFKR 400
WP_111334376 671 -DSLTKLVRRAANRANRKISS-V-E-NAPPASDYPRMKGFPEGDSFEGLWIRTAG 721
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